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Molecular Diagnostics in Cytopathology

A Practical Handbook for the Practicing Pathologist

  • Book
  • © 2019

Overview

Editors:
  1. Sinchita Roy-Chowdhuri

    1. MD Anderson Cancer Center, The University of Texas, Houston, USA

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  2. Paul A. VanderLaan

    1. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA

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  3. John M. Stewart

    1. MD Anderson Cancer Center, The University of Texas, Houston, USA

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  4. Gilda da Cunha Santos

    1. Department of Laboratory Medicine, University of Toronto, Toronto, Canada

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  • Provide a user-friendly quick-reference handbook

  • Written by experts in their fields

  • Richly illustrated with color micrographs, illustrations, and tables

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xv
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  2. Overview of Molecular Cytopathology

    1. Front Matter

      Pages 1-1
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    2. Introduction: Overview of Current Molecular Diagnostic Testing on Cytology Samples

      • Michael H. Roh, Rashmi Kanagal-Shamanna
      Pages 3-19

  3. Laboratory Processing: Practical Considerations

    1. Front Matter

      Pages 21-21
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    2. The Cytology Specimen and Preparations: Advantages and Limitations

      • Gilda da Cunha Santos, Mauro Ajaj Saieg
      Pages 23-38

    3. Sample Acquisition and Test Requisition

      • Ross A. Miller, Ashwyna Sunassee
      Pages 39-60

    4. Pre-analytic Workflow and Specimen Evaluation

      • John M. Stewart
      Pages 61-81

    5. DNA-Based Sequencing Assays

      • Pasquale Pisapia, Miriam Cieri, Francesco Pepe, Umberto Malapelle, Giancarlo Troncone
      Pages 83-97

    6. RNA-Based Assays

      • Umberto Malapelle, Pasquale Pisapia, Miriam Cieri, Francesco Pepe, Giancarlo Troncone
      Pages 99-119

    7. FISH Testing of Cytology Specimens: Pre-analytic, Analytic, and Post-analytic Considerations

      • Karen D. Tsuchiya, Laura J. Tafe, Julia A. Bridge
      Pages 121-159

    8. Molecular Cytopathology Correlations: Interpretation of Molecular Diagnostic Results

      • Sinchita Roy-Chowdhuri
      Pages 161-178

  4. Clinical Relevance

    1. Front Matter

      Pages 179-179
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    2. Human Papillomavirus (HPV) Testing of Head and Neck Cancers

      • Eleanor Russell-Goldman, Jeffrey F. Krane
      Pages 181-197

    3. Human Papillomavirus (HPV) Testing on Cervical Cytology Specimens

      • Ming Guo
      Pages 199-221

    4. Molecular Diagnostics in Lung Cytology

      • Paul A. VanderLaan
      Pages 223-247

    5. Molecular Diagnostics in Thyroid Cytology

      • Michiya Nishino
      Pages 249-299

    6. Molecular Diagnostics in Breast Cytology

      • Liza M. Quintana
      Pages 301-336

    7. Molecular Diagnostics in Salivary Gland Cytology

      • Esther Diana Rossi, Zubair W. Baloch
      Pages 337-353

    8. Molecular Diagnostics in Pancreatic and Biliary Cytology

      • Mingjuan Lisa Zhang, Martha Bishop Pitman
      Pages 355-376

    9. Fluorescence In Situ Hybridization (FISH) Testing in Urinary Tract Cytology

      • Güliz A. Barkan, Stefan E. Pambuccian
      Pages 377-403
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Keywords

About this book

Molecular diagnostics are increasingly used to help guide targeted therapy in solid organ tumors and hematologic malignancies. A large proportion of molecular testing is performed on limited-volume samples obtained via minimally invasive techniques, such as fine needle aspiration. Increasingly, cytopathologists play an essential role in this process, both in the triage of specimens during rapid on-site evaluation and in the evaluation of archival samples to determine suitability for ancillary testing. Therefore, it is imperative that practicing cytopathologists stay abreast of up-to-date diagnostic, prognostic, and predictive ancillary tests that can be used on limited cytologic material. This is a challenge since the landscape of known genomic alterations is constantly evolving and the subsequent set of testing options is ever expanding.

The proposed text will provide a user-friendly quick-reference handbook to serve as a useful resource for practicing pathologists and laboratory personnel dealing with, and interested in, this evolving field of molecular cytopathology. Essential components to be presented include: 1) pre-analytic factors that affect sample selection and evaluation; 2) specimen preparation to maximize confidence in results; 3) interpretation of results; 4) potential limitations; and 5) workflow algorithms.  In addition, specific disease specific molecular testing details will be outlined to provide the reader with resources for quick reference. All chapters will be written by experts in their fields and will include the most up-to-date scientific and clinical information.


Molecular Diagnostics in Cytopathology will be of value to Cytopathologists, Cytotechnologists, Cytotechnology students, Cytopathology fellows, Surgical pathologists, Pathology residents and fellows, Molecular Pathologists, Molecular pathology fellows, Molecular technologists, as well as  Translational researchers with an interest in molecular cytopathology.

Editors and Affiliations

  • MD Anderson Cancer Center, The University of Texas, Houston, USA

    Sinchita Roy-Chowdhuri, John M. Stewart

  • Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, USA

    Paul A. VanderLaan

  • Department of Laboratory Medicine, University of Toronto, Toronto, Canada

    Gilda da Cunha Santos

About the editors

Sinchita Roy-Chowdhuri
The University of Texas MD Anderson Cancer Center
Houston, TX
USA


Paul A. VanderLaan 
Beth Israel Deaconess Medical Center
Harvard Medical School
Boston, MA
USA


John M. Stewart
The University of Texas MD Anderson Cancer Center
Houston, TX
USA



Gilda da Cunha Santos
Sunnybrook Health Science Center
Toronto, Ontario
Canada

Bibliographic Information

  • Book Title: Molecular Diagnostics in Cytopathology

  • Book Subtitle: A Practical Handbook for the Practicing Pathologist

  • Editors: Sinchita Roy-Chowdhuri, Paul A. VanderLaan, John M. Stewart, Gilda da Cunha Santos

  • DOI: https://doi.org/10.1007/978-3-319-97397-5

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer Nature Switzerland AG 2019

  • Softcover ISBN: 978-3-319-97396-8Published: 17 December 2018

  • eBook ISBN: 978-3-319-97397-5Published: 21 November 2018

  • Edition Number: 1

  • Number of Pages: XV, 534

  • Number of Illustrations: 2 b/w illustrations, 91 illustrations in colour

  • Topics: Pathology

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