Non-Alcoholic Fatty Liver Disease

1. Front Matter

   Pages i-x

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2. Obesity and NAFLD: Same Problem?

   • Lucia Brodosi, Francesca Alessandra Barbanti, Maria Letizia Petroni, Francesca Marchignoli, Giulio Marchesini

   Pages 1-14

3. The Burden of NAFLD Worldwide

   • Zobair Younossi, Linda Henry

   Pages 15-24

4. Histopathology of Nonalcoholic Fatty Liver Disease

   • Dina G. Tiniakos, Stratigoula Sakellariou

   Pages 25-47

5. NAFLD and Insulin Resistance: A Multisystemic Disease

   • A. Gastaldelli

   Pages 49-71

6. Etiopathogenesis of NAFLD: Diet, Gut, and NASH

   • Luca Miele, Marco Biolato, Caterina Conte, Francesca Mangiola, Antonio Liguori, Antonio Gasbarrini et al.

   Pages 73-95

7. Mechanisms of Fibrogenesis in NASH

   • Mirella Pastore, Alessandra Gentilini, Fabio Marra

   Pages 97-127

8. The Natural History of NAFLD: Environmental vs. Genetic Risk Factors

   • Luca Valenti, Serena Pelusi

   Pages 129-145

9. NAFLD, Diabetes, and Other Endocrine Diseases: Clinical Implications

   • Giovanni Targher, Alessandro Mantovani

   Pages 147-168

10. NAFLD and Cardiovascular and Cardiac Disease: Clinical Implications

    • Eleonora Scorletti, Christopher D. Byrne

    Pages 169-197

11. NAFLD, Hepatocellular Carcinoma, and Extrahepatic Cancers

    • Ramy Younes, Elisabetta Bugianesi

    Pages 199-209

12. NAFLD in Children: Implication for the Future

    • Claudia Della Corte, Antonella Mosca, Andrea Pietrobattista, Maria Sole Basso, Valerio Nobili

    Pages 211-223

13. Diagnostic Algorithm for the Identification of NAFLD in Primary Care

    • Helena Cortez-Pinto

    Pages 225-234

14. Non-invasive Diagnostic Approach to NASH: Biological Markers

    • Salvatore Petta, Aurora Giannetti

    Pages 235-256

15. Noninvasive Diagnostic Approach to NASH: Radiological Diagnostics

    • Monica A. Tincopa, Stephen A. Harrison

    Pages 257-269

16. Dietary Approach to NAFLD

    • Yolanda Sánchez-Torrijos, Leticia Álvarez-Amor, Rocío Aller, Pedro Pablo García-Luna, Franz Martín, Manuel Romero-Gómez

    Pages 271-287

17. Physical Activity in NAFLD: What and How Much?

    • K. Hallsworth, M. Trenell

    Pages 289-307

18. Pharmacological Options for NASH

    • Christiane Stern, Vlad Ratziu

    Pages 309-327

19. Bariatric Surgery and NASH: A Feasible Option

    • Lidia Castagneto-Gissey, James R. Casella-Mariolo, Geltrude Mingrone

    Pages 329-342

20. Liver Transplantation and NAFLD/NASH

    • Damiano Patrono, Silvia Martini, Renato Romagnoli

    Pages 343-362

The goal of this book is to promote awareness of non-alcoholic fatty liver disease (NAFLD) – which is rapidly replacing viral hepatitis as the leading cause of chronic liver disease in Europe, North and South America and Asia – and to share the latest information on evolving approaches to diagnosis and treatment. The book offers a comprehensive overview of the current topics of interest in the field, and provides clinical guidance on NAFLD through a multidisciplinary approach based on the latest scientific understanding of this multisystemic disease, involving the expertise of specialists including hepatologists, diabetologists, and cardiologists. The respective contributions address various aspects, including the newly released international guidelines, novel diagnostic modalities, and new experimental drugs. The work will appeal to a broad readership, from residents in internal medicine to specialists.​

• Steatohepatitis
• diagnostic algorithm
• non invasive markers
• lifestyle change
• pharmacotherapy
• hepatology

• Department of Medical Sciences, Division of Gastroentrology and Hepatology, University of Turin, Turin, Italy

  Elisabetta Bugianesi

Elisabetta Bugianesi, MD, PhD, is a Professor of Gastroenterology at the University of Torino. After her Medical Degree cum laude and Specialization, she trained three years as a post-doctoral fellow at the Case Western Reserve University (USA). She has been permanent staff of the Gastroenterology Division since 2000. Prof. Bugianesi is currently engaged in clinical research, clinical work and teaching at the Department of Medical Sciences. She is a world-renowned specialist for Non Alcoholic fatty Liver Disease, an area in which her research has helped to identify the mechanisms of liver damage and unravel related complications. In addition, she is currently an Associated Editor for the Journal of Hepatology.

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