Skip to main content
  • Book
  • © 2018

Biomechanics in Oncology

  • Describes how mechanical properties of cancer cells, the extracellular matrix, tumor microenvironment, and fluid flow dynamics contribute to tumor progression and the metastatic process
  • Provides the latest research on non-invasive imaging
  • Includes insight into NCIs’ role in supporting biomechanics in oncology research
  • Details how biomaterials in mechano-oncology can be used as a means to tune materials to study cancer

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1092)

Buy it now

Buying options

eBook USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

This is a preview of subscription content, log in via an institution to check for access.

Table of contents (16 chapters)

  1. Front Matter

    Pages i-xii
  2. The National Cancer Institute Investment in Biomechanics in Oncology Research

    • Anthony Dickherber, Shannon K. Hughes, Nastaran Zahir
    Pages 1-10
  3. DNA Mechanics and Topology

    • Sumitabha Brahmachari, John F. Marko
    Pages 11-39
  4. Mechanics of the Cell Nucleus

    • Dong-Hwee Kim, Jungwon Hah, Denis Wirtz
    Pages 41-55
  5. Extracellular Matrix Stiffness Exists in a Feedback Loop that Drives Tumor Progression

    • Allison K. Simi, Mei-Fong Pang, Celeste M. Nelson
    Pages 57-67
  6. Mechanical Forces in Tumor Angiogenesis

    • Matthew R. Zanotelli, Cynthia A. Reinhart-King
    Pages 91-112
  7. Exposing Cell-Itary Confinement: Understanding the Mechanisms of Confined Single Cell Migration

    • Bin Sheng Wong, Panagiotis Mistriotis, Konstantinos Konstantopoulos
    Pages 139-157
  8. Modeling Cell Migration Mechanics

    • Louis S. Prahl, David J. Odde
    Pages 159-187
  9. Engineered Models of Metastasis with Application to Study Cancer Biomechanics

    • Michelle B. Chen, Roger D. Kamm, Emad Moeendarbary
    Pages 189-207
  10. Biomechanics of the Circulating Tumor Cell Microenvironment

    • Benjamin L. Krog, Michael D. Henry
    Pages 209-233
  11. Platelet-Based Drug Delivery for Cancer Applications

    • Nerymar Ortiz-Otero, Zeinab Mohamed, Michael R. King
    Pages 235-251
  12. Biomaterials in Mechano-oncology: Means to Tune Materials to Study Cancer

    • Shelly R. Peyton, Maria F. Gencoglu, Sualyneth Galarza, Alyssa D. Schwartz
    Pages 253-287
  13. Design of Fiber Networks for Studying Metastatic Invasion

    • Apratim Mukherjee, Aniket Jana, Brian Koons, Amrinder Nain
    Pages 289-318
  14. Traction Force Microscopy for Noninvasive Imaging of Cell Forces

    • Jeffrey A. Mulligan, François Bordeleau, Cynthia A. Reinhart-King, Steven G. Adie
    Pages 319-349
  15. Noninvasive Imaging: Brillouin Confocal Microscopy

    • MiloÅ¡ Nikolić, Christina Conrad, Jitao Zhang, Giuliano Scarcelli
    Pages 351-364
  16. Back Matter

    Pages 365-376

About this book

This book covers multi-scale biomechanics for oncology, ranging from cells and tissues to whole organ. Topics covered include, but not limited to, biomaterials in mechano-oncology, non-invasive imaging techniques, mechanical models of cell migration, cancer cell mechanics, and platelet-based drug delivery for cancer applications. This is an ideal book for graduate students, biomedical engineers, and researchers in the field of mechanobiology and oncology.

This book also:

Describes how mechanical properties of cancer cells, the extracellular matrix, tumor microenvironment and immuno-editing,  and fluid flow dynamics contribute to tumor progression and the metastatic process

Provides the latest research on non-invasive imaging, including traction force microscopy and brillouin confocal microscopy

Includes insight into NCIs’ role in supporting biomechanics in oncology research

Details how biomaterials in mechano-oncology can be used as a means to tune materials to study cancer

Editors and Affiliations

  • Department of Biomedical Engineering, Pennsylvania State University, University Park, USA

    Cheng Dong

  • Division of Cancer Biology, National Cancer Institute, National Institutes of Health, Rockville, USA

    Nastaran Zahir

  • Department of Chemical and Biomolecular Engineering Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, USA

    Konstantinos Konstantopoulos

About the editors

Cheng Dong is Distinguished Professor and Department Head of the Department of Biomedical Engineering at Pennsylvania State University.

Nastaran Zahir is Associate Director of the Division of Cancer Biology and Program Director of the Physical Sciences-Oncology Initiative at the National Cancer Institute.

Konstantinos Konstantopoulos is Professor of the Department of Chemical & Biomolecular Engineering at Johns Hopkins University.


Bibliographic Information

Buy it now

Buying options

eBook USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 179.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access