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Copper and Bacteria

Evolution, Homeostasis and Toxicity

  • Book
  • © 2018

Overview

Authors:
  1. Marc Solioz

    1. Department Clinical Research, University of Bern, Bern, Switzerland

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  • Broadens understanding of copper homeostasis and toxicity
  • Outlines the evolution of copper use by cells
  • Elucidates the contact killing of bacteria by metallic copper

Part of the book series: SpringerBriefs in Molecular Science (BRIEFSMOLECULAR)

Part of the book sub series: SpringerBriefs in Biometals (SB BIOMETALS)

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Table of contents (5 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Copper—A Modern Bioelement

    • Marc Solioz
    Pages 1-9

  3. Copper Toxicity

    • Marc Solioz
    Pages 11-19

  4. Copper Homeostasis in Gram-Positive Bacteria

    • Marc Solioz
    Pages 21-48

  5. Copper Homeostasis in Gram-Negative Bacteria

    • Marc Solioz
    Pages 49-80

  6. Conclusions

    • Marc Solioz
    Pages 81-84

  7. Back Matter

    Pages 85-88
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Keywords

About this book

In the past two decades, great progress has been made in the understanding of copper as a bioelement. The book summarizes the current knowledge of copper toxicity, homeostasis and resistance in bacteria, in which proteins like copper ATPases, copper chaperones and copper-responsive regulators of gene expression play major roles. The author also discusses the metallation of cuproenzymes. The evolution of the use of copper by cells and of copper-homeostatic proteins are is also considered in this Brief.

Authors and Affiliations

  • Department Clinical Research, University of Bern, Bern, Switzerland

    Marc Solioz

About the author

A native of Zurich, Marc Solioz studied chemistry and engineering in Zurich. He then moved to the US, where he obtained his PhD in Biochemistry at St. Louis University in 1975. The PhD work focused on genetic transfer in photosynthetic bacteria. During postdoctoral studies at the Biocenter in Basel, he investigated the genetics and biogenesis of mitochondria. This was followed by seven years as an assistant professor at the ETH in Zurich, where he investigated ion transport by cytochrome oxidases and ATPases. In 1989 he became professor of biochemistry at the University of Bern. With the discovery of the first copper-pumping ATPase in 1992, Marc's focus shifted to copper, including copper-related diseases and the antimicrobial activity of metallic copper; work in this area included advisory activity on government and industry panels. In 2014, he received a grant from the Russian Government to build up a new laboratory in Tomsk, Siberia, where work on copper and other heavy metals continues.

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