Overview
- Summarizes the most recent advances in human neural stem cells (hNSC) research
- Presents hNSC derivation methods
- Discusses mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action
- Outlines therapeutic potential of human neural stem cells
Part of the book series: Results and Problems in Cell Differentiation (RESULTS, volume 66)
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Table of contents (14 chapters)
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Derivation and/or Generation of Human Neural Stem Cells
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Differentiation and Underlying Mechanisms
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Therapeutic Potential of Human Neural Stem Cells
Keywords
About this book
This book summarizes early pioneering achievements in the field of human neural stem cell (hNSC) research and combines them with the latest advances in stem cell technology, including reprogramming and gene editing. The powerful potential of hNSC to generate and repair the developing and adult CNS has been confirmed by numerous experimental in vitro and in vivo studies. The book presents methods for hNSC derivation and discusses the mechanisms underlying NSC in vitro fate decisions and their in vivo therapeutic mode of action.
The long-standing dogma that the human central nervous system (CNS) lacks the ability to regenerate was refuted at the end of the 20th century, when evidence of the presence of neurogenic zones in the adult human brain was found. These neurogenic zones are home to human neural stem cells (hNSCs), which are capable of self-renewing and differentiating into neurons, astrocytes and oligodendrocytes. NSCs isolated from human CNS have a number of clinical advantages, especially the innate potential to differentiate into functional neural cells. Nevertheless, their full clinical exploitation has been hindered by limited access to the tissue and low expansion potential. The search for an alternative to CNS sources of autologous, therapeutically competent hNSCs was the driving force for the many studies proving the in vitro plasticity of different somatic stem cells to generate NSCs and their functional progeny. Now the era of induced pluripotent stem cells has opened entirely new opportunities to achieve research and therapeutic goals with the aid of hNSCs.
Editors and Affiliations
Bibliographic Information
Book Title: Human Neural Stem Cells
Book Subtitle: From Generation to Differentiation and Application
Editors: Leonora Buzanska
Series Title: Results and Problems in Cell Differentiation
DOI: https://doi.org/10.1007/978-3-319-93485-3
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing AG, part of Springer Nature 2018
Hardcover ISBN: 978-3-319-93484-6Published: 22 September 2018
Softcover ISBN: 978-3-030-06671-0Published: 20 December 2018
eBook ISBN: 978-3-319-93485-3Published: 12 September 2018
Series ISSN: 0080-1844
Series E-ISSN: 1861-0412
Edition Number: 1
Number of Pages: XI, 329
Number of Illustrations: 1 b/w illustrations, 40 illustrations in colour
Topics: Stem Cells, Gene Function, Neurosciences, Gene Therapy, Cytogenetics