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Hypofractionated and Stereotactic Radiation Therapy

A Practical Guide

  • Book
  • © 2018

Overview

Editors:
  1. Orit Kaidar-Person

    1. Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Ronald Chen

    1. Department of Radiation Oncology, University of North Carolina, Chapel Hill, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Easily accessible handbook that summarizes published data on efficacy of different dose fractionations and the dose/volume/outcome data for relevant normal tissues and organs under different fractionation schemes
  • Presents biological rationale and clinical data for use of hypofractionated radiation therapy in treatment of various cancers
  • Serves as valuable resource through analysis of different dosing schedules used in hypofractionated radiation therapy, effect of each regimen on cancer control, and effects of therapeutic schedules on normal tissues and organs

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Table of contents (27 chapters)

  1. Front Matter

    Pages i-xxvii
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  2. The History and Radiobiology of Hypofractionation

    • Elaine M. Zeman
    Pages 1-31

  3. The Physics of Hypofractionation and SRS/SBRT

    • Jason Matney, Alex Price, Leith Rankine
    Pages 33-59

  4. Benign Central Nervous System Tumors

    1. Front Matter

      Pages 61-61
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    2. Arteriovenous Malformation

      • Katelyn M. Atkins, Marc Bussière, Helen A. Shih
      Pages 63-73

    3. Trigeminal Neuralgia

      • Katelyn M. Atkins, Marc Bussière, Helen A. Shih
      Pages 75-81

    4. Meningioma

      • Katelyn M. Atkins, Marc Bussière, Helen A. Shih
      Pages 83-93

    5. Vestibular Schwannoma

      • Katelyn M. Atkins, Marc Bussière, Helen A. Shih
      Pages 95-104

    6. Pituitary Adenoma

      • Katelyn M. Atkins, Marc Bussière, Helen A. Shih
      Pages 105-114

  5. Malignant Central Nervous System Tumors

    1. Front Matter

      Pages 115-115
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    2. Glioblastoma

      • Dominic H. Moon, Timothy M. Zagar
      Pages 117-125

    3. Secondary Malignant (Metastases)

      • Dominic H. Moon, Timothy M. Zagar
      Pages 127-140

  6. Head and Neck Tumors

    1. Front Matter

      Pages 141-141
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    2. Nasopharynx

      • Gregory D. Judy, Bhishamjit S. Chera
      Pages 143-154

    3. Larynx

      • Gregory D. Judy, Bhishamjit S. Chera
      Pages 155-163

    4. Other Head and Neck Sites

      • Gregory D. Judy, Bhishamjit S. Chera
      Pages 165-166

    5. Intraoral Cone (IOC)

      • Gregory D. Judy, Bhishamjit S. Chera
      Pages 167-169

    6. Brachytherapy

      • Gregory D. Judy, Bhishamjit S. Chera
      Pages 171-178

    7. Intraoperative Radiotherapy (IORT)

      • Gregory D. Judy, Bhishamjit S. Chera
      Pages 179-181

    8. Re-irradiation

      • Gregory D. Judy, Bhishamjit S. Chera
      Pages 183-185
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Keywords

About this book

This handbook summarizes the data and techniques for hypofractionation and stereotactic radiation in a clinically-accessible way. Hypofractionated radiation therapy, which consists of larger-dose radiation treatments that are given over a shorter time period compared to conventional radiation fraction sizes, is used to treat a variety of cancers, including prostate, breast, lung,  and colorectal.  Conventional radiation therapy and hypofractionated radiation therapy have different effectiveness rates for cancer treatment and have different impacts on normal tissues in terms of causing toxicity. There is a significant and growing body of literature on the use of different dosing regimens to treat a variety of cancers and radiation oncologists need to keep up with the various dosing schedules, the effect of each regimen on cancer control in different cancers, and how the different schedules affect each organ in terms of toxicity. The book thus provides concise information ranging from commonly-used dose-fractionation schemes for hypofractionated and stereotactic body radiotherapy to simulation and treatment specifications to published safety and efficacy data. Chapters additionally examine the biological rationales for the efficacy of hypofractionated radiation; present clinical studies that demonstrate the efficacy and safety of hypofractionated radiation treatment in a variety of cancers; and describe the advances in technology that have allowed hypofractionated radiation to be safely given. This is an ideal guide for radiation oncology clinicians and trainees. 

Reviews

“This book is an excellent review of the literature supporting the usage of hypofractionated radiotherapy. It is well organized and presents in tabular format important indications for hypofractionated radiotherapy. Of the readership of Neurosurgery, CNS radiation oncologists, brain and spine tumor neurosurgeons, and radiation oncology residents would particularly benefit from the expertise provided in this review. Community radiation oncologists would also find this review quite useful given the relative novelty of hypofractionated radiotherapy … .” (Michael Chan, Neurosurgery, Vol. 85 (3), September, 2019)

“The book provides a his­tory of radiobiology and hypofractionation, giving a concise background of how both radiation therapy and the understandings of radiobiology have co-evolved before discussing further the physics behind hypofractionation and SRS/SBRT. …  the book is very well presented and is designed to be a ‘handbook’ that is both relevant and accessible, with current information enabling the reader to locate and utilise practical and supported data.” (Craig Jones, RAD Magazine, March, 2019)

Editors and Affiliations

  • Department of Radiation Oncology, University of North Carolina School of Medicine, Chapel Hill, USA

    Orit Kaidar-Person

  • Department of Radiation Oncology, University of North Carolina, Chapel Hill, USA

    Ronald Chen

About the editors

Orit Kaidar-Person, Department of Radiation Oncology,University of North Carolina School of Medicine, Chapel Hill, North Carolina,USA
Oncology Institute, Radiation Oncology and Neuro-Oncology Unit,Rambam Medical Center, Haifa, Israel




Ronald Chen, MD, MPH Department of Radiation Oncology University of North Carolina at Chapel Hill School of Medicine 101 Manning Drive, CB 7512 Chapel Hill, NC 27599 Lawrence B. Marks, MD Department of Radiation Oncology University of North Carolina at Chapel Hill School of Medicine 1043 NC Clinical Cancer Building Chapel Hill, NC 27599



Bibliographic Information

  • Book Title: Hypofractionated and Stereotactic Radiation Therapy

  • Book Subtitle: A Practical Guide

  • Editors: Orit Kaidar-Person, Ronald Chen

  • DOI: https://doi.org/10.1007/978-3-319-92802-9

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing AG, part of Springer Nature 2018

  • Softcover ISBN: 978-3-319-92800-5Published: 15 August 2018

  • eBook ISBN: 978-3-319-92802-9Published: 31 July 2018

  • Edition Number: 1

  • Number of Pages: XXVII, 406

  • Number of Illustrations: 11 b/w illustrations, 40 illustrations in colour

  • Topics: Radiotherapy, Oncology

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