Overview
- Discusses the most recent developments in targeted therapy in hematology using small molecules
- Describes chemical structure, mechanism of action, drug targets, and drug interactions
- Examines preclinical studies, clinical trials, and treatment applications
Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 212)
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Table of contents (14 chapters)
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Front Matter
Keywords
About this book
This book, written by respected experts, discusses in detail the latest developments in targeted therapy for hematologic malignancies using small molecules. It covers a wide range of small molecules including tyrosine kinase inhibitors, immunomodulatory drugs, the IDH-2 inhibitor enasidenib, the BCL-2 inhibitor venetoclax, and the proteasome inhibitor carfilzomib. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed.
Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of precision cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. An accompanying volume addresses the use of small molecules in oncology, and the two volumes together represent the third edition of the book originally published under the same title.
Editors and Affiliations
About the editor
Bibliographic Information
Book Title: Small Molecules in Hematology
Editors: Uwe M. Martens
Series Title: Recent Results in Cancer Research
DOI: https://doi.org/10.1007/978-3-319-91439-8
Publisher: Springer Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer International Publishing AG, part of Springer Nature 2018
Hardcover ISBN: 978-3-319-91438-1Published: 16 August 2018
Softcover ISBN: 978-3-030-08256-7Published: 10 January 2019
eBook ISBN: 978-3-319-91439-8Published: 01 August 2018
Series ISSN: 0080-0015
Series E-ISSN: 2197-6767
Edition Number: 3
Number of Pages: VIII, 294
Number of Illustrations: 11 b/w illustrations, 17 illustrations in colour
Additional Information: Originally published in one volume in previous edition
Topics: Hematology, Oncology