Oxygen Transport to Tissue XL

The book contains the refereed contributions from the 45^th Annual Meeting of the International Society on Oxygen Transport to Tissue (ISOTT) 2017. This volume covers cross-disciplinary work on a broad range of topics related to the dynamics of oxygen transport: microcirculation and vascular medicine; O₂ deficiency and its impact on molecular processes in cells and tissues; cellular metabolism and mitochondrial function; multimodal functional imaging; mathematical modeling; the clinical relevance of oxygen supply as well as therapeutic interventions (e.g. in oncology or critical care medicine). The annual meetings of ISOTT bring together scientists from diverse fields (medicine, physiology, mathematics, biology, chemistry, physics, engineering, etc.) in a unique international forum. The book includes sections on brain oxygenation and function, NIRS oxygenation measurements, tumor oxygenation, cell metabolism, tissue oxygenation and treatment, methodical aspectsof O₂ measurements and physicochemical aspects of oxygen diffusion.

Chapters 3, 24, 49 and 51 of this book are open access under a CC BY 4.0 license.

• ISOTT
• metabolism
• measurement
• tumors
• molecular signaling
• oxygenation

• Julius Bernstein Institute of Physiology, Martin Luther University, Halle-Wittenberg, Halle/Saale, Germany

  Oliver Thews

• Department of Physiology & Biophysics, Case Western Reserve University, School of Medicine, Cleveland, USA

  Joseph C. LaManna

• Microvascular Measurements, St. Lorenzen, Italy

  David K. Harrison

Oliver Thews is Professor of Physiology at the Martin Luther University Halle-Wittenberg, Germany. He studied medicine at the University of Mainz and worked there at the Institute of Medical Statistics and Documentation as well as at the Institute of Physiology. After a temporary professorship of physiology at the University of Würzburg he moved to the Julius-Bernstein-Institute of Physiology at the University of Halle. His major research field is the role of metabolic parameters such as hypoxia and acidosis on the biological behavior of tumor cells. He is interested in the therapeutic relevance of microenvironmental tissue parameters and the mechanisms by which these parameters act. In addition, his research focusses on functional in vivo imaging using Positron Emission Tomography. He has served as the Secretary of ISOTT since 1999.

Joseph C. LaManna is the Jeanette M. and Joseph S. Silber Professor of Brain Sciences at the Case Western Reserve University Schoolof Medicine, Department of Physiology & Biophysics. He is the former chair of the Department of Anatomy at CWRU.  He is a Past President of The Federation of American Societies for Experimental Biology (FASEB), and Secretary of the International Society for Cerebral Blood Blow and Metabolism. He has published over 250 papers on the topic of oxygen and energy metabolism, especially in the field of brain blood flow and metabolism. He has been a member of the International Society for Oxygen Transport to Tissue since 1976, serving as President of the ISOTT in 2009. In 2016 he became the editor in Chief of the ISOTT proceedings.

David Harrison is CEO of Microvascular Measurements and acts as honorary Senior Scientific Consultant for Oroboros Instruments (Innsbruck, Austria). In this capacity he has recently been responsible for the development of lightguide spectrophotometry for the continuous measurement of cytochrome redox state in mitochondria during high resolution respirometry. Prior to this, he was Head of the Durham Unit of the Regional Medical Physics Department and Honorary Senior Lecturer in Medical Physics, Institute of Cellular Medicine, Newcastle University, UK until retiring from the NHS in 2009. He is author or co-author of over 130 publications, mainly in the field of blood flow and oxygen transport to tissue. He has been a member of ISOTT for over 30 years including being President in 1996. Since 2004 he has been Scientific Editor of the “Oxygen Transport to Tissue” volumes.

Policies and ethics