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Fibrostenotic Inflammatory Bowel Disease

  • Book
  • © 2018

Overview

Editors:
  1. Florian Rieder

    1. Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic Foundation, Cleveland, USA

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  • Examines both pathophysiological and clinical aspects of the disease

  • Offers access to videos for medical and surgical intervention

  • Discusses current and future drug therapies

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Table of contents (23 chapters)

  1. Front Matter

    Pages i-xii
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  2. Fibrostenotic Inflammatory Bowel Disease: A Cinderella Story

    • Florian Rieder
    Pages 1-4

  3. Epidemiology and Natural History of Fibrostenosing Inflammatory Bowel Disease

    • Wee Khoon Ng, Siew C. Ng
    Pages 5-12

  4. Genetic Influences on the Development of Fibrosis in Inflammatory Bowel Disease

    • Bram Verstockt, Sare Verstockt, Isabelle Cleynen
    Pages 13-38

  5. Epigenetic Regulation of Intestinal Fibrosis

    • Chao Li, John F. Kuemmerle
    Pages 39-58

  6. Cytokine and Anti-Cytokine Agents as Future Therapeutics for Fibrostenosing IBD

    • Noam Jacob, Stephan R. Targan, David Q. Shih
    Pages 59-75

  7. Inflammation-Independent Mechanisms of Intestinal Fibrosis: The Role of the Extracellular Matrix

    • Debby Laukens
    Pages 77-95

  8. Fat and Fibrosis

    • Ren Mao, J. Calvin Coffey
    Pages 97-109

  9. Environmental Factors and Their Influence on Intestinal Fibrosis

    • Claudio Bernardazzi, Fernando Castro, Heitor S. de Souza
    Pages 111-126

  10. Animal Models and Sources of Mesenchymal Cells in Intestinal Fibrosis

    • Dominik Bettenworth
    Pages 127-145

  11. Fibrosis in Ulcerative Colitis

    • Fernando Magro, Tatiana António
    Pages 147-157

  12. Histopathology of Intestinal Fibrosis

    • Ilyssa O. Gordon
    Pages 159-171

  13. Clinical, Cellular and Serologic Biomarkers of Intestinal Fibrosis

    • Antonio Di Sabatino, Paolo Giuffrida
    Pages 173-181

  14. Imaging in Intestinal Fibrosis. What Is State of the Art?

    • Jordi Rimola
    Pages 183-192

  15. The Future of Intestinal Fibrosis Imaging

    • Ryan W. Stidham, Mahmoud Al-Hawary
    Pages 193-208

  16. Medical Therapy in Stricturing Inflammatory Bowel Diseases

    • Damien Soudan, Yoram Bouhnik
    Pages 209-223

  17. Endoscopic Therapy of Intestinal Strictures: What Is State of the Art?

    • Talat Bessissow, Gert Van Assche
    Pages 225-232

  18. Resectional Surgery for Intestinal Strictures: What Is State of the Art?

    • Karin A. T. G. M. Wasmann, Christianne J. Buskens, Pieter J. Tanis, Willem A. Bemelman
    Pages 233-252

  19. Management of Ileal Pouch Strictures and Anal Stricturing Disease: A Clinical Challenge

    • Jean H. Ashburn, Tracy L. Hull
    Pages 253-266

  20. Stricturing Crohn’s Disease: Strictureplasty

    • Gabriele Bislenghi, Andre D’Hoore
    Pages 267-293
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Keywords

About this book

This book provides a comprehensive account of the pathogenesis and treatment of intestinal fibrosis, covering both the clinical and molecular aspects of the disease. It begins by describing the epidemiology and genetics of fibrostenosing IBD in Crohn’s disease and Ulcerative colitis as well as the epigenetics and cellular and molecular mechanisms of the disease. Readers will obtain an in-depth overview of the disease from biomarkers and histology to surgical intervention, imaging and current and future drug therapies. Medical management of fibrosis, endoscopy and imaging as well as surgical approaches are all discussed. Through the links to videos contained in the book, the reader will become familiar with interventional procedures such as endoscopic balloon dilation and surgical techniques for stricturing IBD, such as resection and strictureplasties. This is an indispensable volume for anyone working on fibrostenotic IBD, such as gastroenterologists, internists, radiologists, colorectal surgeons, pathologists and researchers. It has been written by a team of top experts from North America, Asia and Europe.

 


Editors and Affiliations

  • Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic Foundation, Cleveland, USA

    Florian Rieder

About the editor

Dr. Rieder is a principal investigator at the Department of Inflammation and Immunity and an Associate Clinical Staff at the Department of Gastroenterology, Hepatology & Nutrition at the Cleveland Clinic, Cleveland. His focus is the field of pathogenesis, prediction and therapy of intestinal fibrosis. He is a fully trained Internist and Gastroenterologist with an IBD focussed clinical and endoscopic practice. He initiated and organized international clinical consensus meetings. Dr. Rieder published more than 70 articles and book chapters in high impact journals, including Science Translational Medicine, Gastroenterology and Gut. He has been recognized for his expertise as indicated through invitations to the steering committee of the 2nd European Crohn’s and Colitis Organization (ECCO) scientific workshop on ‘Intestinal healing’, group leader of the 4th ECCO scientific workshop on ‘Intestinal fibrosis’, invitations as a full member of the consensus panel of the ECCO guidelines on Crohn’s disease, lead author of the ECCO guidelines on Ulcerative colitis and lead author of the first ECCO clinical consensus on ‘Diagnosis and Management of Intestinal Fibrosis’ as well as multiple international invitations as a speaker, session chair or conference faculty. Dr. Rieder is an associate editor (Clinical and Translational Gastroenterology) and on several editorial boards of medical journals (Journal of Crohn’s and Colitis, Inflammatory Bowel Disease, Gastroenterology and Hepatology, Fibrogenesis and Tissue Repair, American Journal of Physiology Gastrointestinal and Liver Physiology). He is proud of his significant ties to the ECCO, which he served as the chair of Y-ECCO, member of the ECCO operational board and currently member of the scientific committee. He is REACH-IBD and is a member of the Professional Education Committee of the CCFA.

Bibliographic Information

  • Book Title: Fibrostenotic Inflammatory Bowel Disease

  • Editors: Florian Rieder

  • DOI: https://doi.org/10.1007/978-3-319-90578-5

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing AG, part of Springer Nature 2018

  • Hardcover ISBN: 978-3-319-90577-8Published: 18 September 2018

  • Softcover ISBN: 978-3-030-08046-4Published: 29 December 2018

  • eBook ISBN: 978-3-319-90578-5Published: 04 September 2018

  • Edition Number: 1

  • Number of Pages: XII, 397

  • Number of Illustrations: 3 b/w illustrations, 67 illustrations in colour

  • Topics: Gastroenterology, Pathology, Surgery

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