Fibrostenotic Inflammatory Bowel Disease

1. Front Matter

   Pages i-xii

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2. Fibrostenotic Inflammatory Bowel Disease: A Cinderella Story

   • Florian Rieder

   Pages 1-4

3. Epidemiology and Natural History of Fibrostenosing Inflammatory Bowel Disease

   • Wee Khoon Ng, Siew C. Ng

   Pages 5-12

4. Genetic Influences on the Development of Fibrosis in Inflammatory Bowel Disease

   • Bram Verstockt, Sare Verstockt, Isabelle Cleynen

   Pages 13-38

5. Epigenetic Regulation of Intestinal Fibrosis

   • Chao Li, John F. Kuemmerle

   Pages 39-58

6. Cytokine and Anti-Cytokine Agents as Future Therapeutics for Fibrostenosing IBD

   • Noam Jacob, Stephan R. Targan, David Q. Shih

   Pages 59-75

7. Inflammation-Independent Mechanisms of Intestinal Fibrosis: The Role of the Extracellular Matrix

   • Debby Laukens

   Pages 77-95

8. Fat and Fibrosis

   • Ren Mao, J. Calvin Coffey

   Pages 97-109

9. Environmental Factors and Their Influence on Intestinal Fibrosis

   • Claudio Bernardazzi, Fernando Castro, Heitor S. de Souza

   Pages 111-126

10. Animal Models and Sources of Mesenchymal Cells in Intestinal Fibrosis

    • Dominik Bettenworth

    Pages 127-145

11. Fibrosis in Ulcerative Colitis

    • Fernando Magro, Tatiana António

    Pages 147-157

12. Histopathology of Intestinal Fibrosis

    • Ilyssa O. Gordon

    Pages 159-171

13. Clinical, Cellular and Serologic Biomarkers of Intestinal Fibrosis

    • Antonio Di Sabatino, Paolo Giuffrida

    Pages 173-181

14. Imaging in Intestinal Fibrosis. What Is State of the Art?

    • Jordi Rimola

    Pages 183-192

15. The Future of Intestinal Fibrosis Imaging

    • Ryan W. Stidham, Mahmoud Al-Hawary

    Pages 193-208

16. Medical Therapy in Stricturing Inflammatory Bowel Diseases

    • Damien Soudan, Yoram Bouhnik

    Pages 209-223

17. Endoscopic Therapy of Intestinal Strictures: What Is State of the Art?

    • Talat Bessissow, Gert Van Assche

    Pages 225-232

18. Resectional Surgery for Intestinal Strictures: What Is State of the Art?

    • Karin A. T. G. M. Wasmann, Christianne J. Buskens, Pieter J. Tanis, Willem A. Bemelman

    Pages 233-252

19. Management of Ileal Pouch Strictures and Anal Stricturing Disease: A Clinical Challenge

    • Jean H. Ashburn, Tracy L. Hull

    Pages 253-266

20. Stricturing Crohn’s Disease: Strictureplasty

    • Gabriele Bislenghi, Andre D’Hoore

    Pages 267-293

This book provides a comprehensive account of the pathogenesis and treatment of intestinal fibrosis, covering both the clinical and molecular aspects of the disease. It begins by describing the epidemiology and genetics of fibrostenosing IBD in Crohn’s disease and Ulcerative colitis as well as the epigenetics and cellular and molecular mechanisms of the disease. Readers will obtain an in-depth overview of the disease from biomarkers and histology to surgical intervention, imaging and current and future drug therapies. Medical management of fibrosis, endoscopy and imaging as well as surgical approaches are all discussed. Through the links to videos contained in the book, the reader will become familiar with interventional procedures such as endoscopic balloon dilation and surgical techniques for stricturing IBD, such as resection and strictureplasties. This is an indispensable volume for anyone working on fibrostenotic IBD, such as gastroenterologists, internists, radiologists, colorectal surgeons, pathologists and researchers. It has been written by a team of top experts from North America, Asia and Europe.

 

• fibrostenotic IBD
• intestinal strictures
• ulcerative colitis
• anti-fibrotic therapies
• intestinal fibrosis
• intestinal ultrasound
• strictureplasty
• cytokines
• extracellular matrix
• postoperative fibrosis
• Endoscopic balloon dilatation

• Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute, Cleveland Clinic Foundation, Cleveland, USA

  Florian Rieder

Dr. Rieder is a principal investigator at the Department of Inflammation and Immunity and an Associate Clinical Staff at the Department of Gastroenterology, Hepatology & Nutrition at the Cleveland Clinic, Cleveland. His focus is the field of pathogenesis, prediction and therapy of intestinal fibrosis. He is a fully trained Internist and Gastroenterologist with an IBD focussed clinical and endoscopic practice. He initiated and organized international clinical consensus meetings. Dr. Rieder published more than 70 articles and book chapters in high impact journals, including Science Translational Medicine, Gastroenterology and Gut. He has been recognized for his expertise as indicated through invitations to the steering committee of the 2nd European Crohn’s and Colitis Organization (ECCO) scientific workshop on ‘Intestinal healing’, group leader of the 4th ECCO scientific workshop on ‘Intestinal fibrosis’, invitations as a full member of the consensus panel of the ECCO guidelines on Crohn’s disease, lead author of the ECCO guidelines on Ulcerative colitis and lead author of the first ECCO clinical consensus on ‘Diagnosis and Management of Intestinal Fibrosis’ as well as multiple international invitations as a speaker, session chair or conference faculty. Dr. Rieder is an associate editor (Clinical and Translational Gastroenterology) and on several editorial boards of medical journals (Journal of Crohn’s and Colitis, Inflammatory Bowel Disease, Gastroenterology and Hepatology, Fibrogenesis and Tissue Repair, American Journal of Physiology Gastrointestinal and Liver Physiology). He is proud of his significant ties to the ECCO, which he served as the chair of Y-ECCO, member of the ECCO operational board and currently member of the scientific committee. He is REACH-IBD and is a member of the Professional Education Committee of the CCFA.

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