Voltage-gated Sodium Channels: Structure, Function and Channelopathies

1. Front Matter

   Pages i-x

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2. Evolution of Voltage-Gated Sodium Channels

   1. Front Matter

      Pages 1-1

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   2. Evolutionary History of Voltage-Gated Sodium Channels

      • Atsuo Nishino, Yasushi Okamura

      Pages 3-32

   3. Mining Protein Evolution for Insights into Mechanisms of Voltage-Dependent Sodium Channel Auxiliary Subunits

      • Steven Molinarolo, Daniele Granata, Vincenzo Carnevale, Christopher A. Ahern

      Pages 33-49

3. The Structural Basis of Sodium Channel Function

   1. Front Matter

      Pages 51-51

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   2. Structural and Functional Analysis of Sodium Channels Viewed from an Evolutionary Perspective

      • Tamer M. Gamal El-Din, Michael J. Lenaeus, William A. Catterall

      Pages 53-72

   3. The Cardiac Sodium Channel and Its Protein Partners

      • Elise Balse, Catherine Eichel

      Pages 73-99

   4. Posttranslational Modification of Sodium Channels

      • Zifan Pei, Yanling Pan, Theodore R. Cummins

      Pages 101-124

   5. Sodium Channel Trafficking

      • A. Mercier, P. Bois, A. Chatelier

      Pages 125-145

   6. pH Modulation of Voltage-Gated Sodium Channels

      • Colin H. Peters, Mohammad-Reza Ghovanloo, Cynthia Gershome, Peter C. Ruben

      Pages 147-160

   7. Regulation of Cardiac Voltage-Gated Sodium Channel by Kinases: Roles of Protein Kinases A and C

      • Ademuyiwa S. Aromolaran, Mohamed Chahine, Mohamed Boutjdir

      Pages 161-184

4. Drugs and Toxins Interactions with Sodium Channels

   1. Front Matter

      Pages 185-185

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   2. Toxins That Affect Voltage-Gated Sodium Channels

      • Yonghua Ji

      Pages 187-207

   3. Mechanisms of Drug Binding to Voltage-Gated Sodium Channels

      • M. E. O’Leary, M. Chahine

      Pages 209-231

   4. Effects of Benzothiazolamines on Voltage-Gated Sodium Channels

      • Alessandro Farinato, Concetta Altamura, Jean-François Desaphy

      Pages 233-250

   5. Structural Models of Ligand-Bound Sodium Channels

      • Boris S. Zhorov

      Pages 251-269

   6. Selective Ligands and Drug Discovery Targeting the Voltage-Gated Sodium Channel Nav1.7

      • Jian Payandeh, David H. Hackos

      Pages 271-306

5. Pathophysiology of Sodium Channels

   1. Front Matter

      Pages 307-307

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   2. Sodium Channelopathies of Skeletal Muscle

      • Stephen C. Cannon

      Pages 309-330

   3. Cardiac Arrhythmias Related to Sodium Channel Dysfunction

      • Eleonora Savio-Galimberti, Mariana Argenziano, Charles Antzelevitch

      Pages 331-354

This book provides a timely state-of-the-art overview of voltage-gated sodium channels, their structure-function, their pharmacology and related diseases. Among the topics discussed are the structural basis of Na+ channel function, methodological advances in the study of Na+ channels, their pathophysiology and drugs and toxins interactions with these channels and their associated channelopathies.

• voltage-gated sodiium channels
• Biophysics
• Channelopathies
• Electrophysiology
• Pharmacology
• Protein Structure

• CERVO Brain Research Center, Institut Universitaire en Santé Mentale, Quebec, Canada

  Mohamed Chahine

Dr. Mohamed Chahine is a Professor at the Department of Medicine of Université Laval and Head of the Laboratory of Cellular Electrophysiology at the CERVO Brain Research Center of the Institut universitaire en santé mentale de Québec. He has published over 160 articles in refereed journals as well as several book chapters in the field of voltage-gated Na+ channels and related diseases. Dr. Chahine has served or is currently serving on various committees of the Canadian Institutes of Health Research and the Heart and Stroke Foundation of Canada. He is associate editor of Frontiers Journal and editor of Scientific Reports. He is a member of the editorial boards of the Canadian Journal of Cardiology (Canada), the World Journal of Cardiology (China), the Journal of Cardiovascular Research (USA), Advances in Bioscience and Biotechnology (USA), and the Journal of Cardiology and Therapy (Hong Kong). He has also organized several national and International symposia and workshops on the role ofion channels in disease. Dr. Chahine has been invited to present his research at several national and international conferences and academic institutions.

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