Chimerism

1. Front Matter

   Pages i-xi

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2. Causes of Chimerism in Humans

   1. Front Matter

      Pages 1-1

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   2. Fertilization and Early Embryonic Errors

      • Nicole L. Draper, Kristy Crooks

      Pages 3-17

   3. Pregnancy and Multiple Gestations

      • Linda Marie Randolph, Ramen H. Chmait

      Pages 19-31

   4. Transplantation and Transfusion

      • Joel N. Kniep

      Pages 33-48

3. Clinical Identification and Consequences of Chimerism

   1. Front Matter

      Pages 49-49

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   2. Relationship Testing and Forensics

      • Kayla Sheets, Robert Wenk

      Pages 51-63

   3. Prenatal Genetic Testing and Screening

      • Ignatia B. Van den Veyver

      Pages 65-79

   4. Blood Typing Discrepancies

      • Opal L. Reddy, Dawn C. Ward, Andrea M. McGonigle

      Pages 81-103

   5. Hematopoietic Stem Cell Donor Selection and Graft-Versus-Host Disease

      • Alexa J. Siddon, Christopher A. Tormey

      Pages 105-117

   6. Passenger Lymphocyte Syndrome

      • Nicole L. Draper, Jamie E. Kallan

      Pages 119-134

   7. Chimerism: A Clinical Guide to Tolerance Induction

      • Andrea R. Merchak, Anita Y. Chhabra, Joseph R. Leventhal, Suzanne T. Ildstad

      Pages 135-152

   8. Autoimmune Disease

      • Nathalie Lambert

      Pages 153-179

   9. Cancer

      • Valentina Cirello, Laura Fugazzola

      Pages 181-194

4. Back Matter

   Pages 195-200

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This text provides a comprehensive, up-to-date review of chimerism. The first part of the volume presents the causes of chimerism, specifically focusing on fertilization and early embryonic errors, pregnancy and multiple gestations, and transplantation and transfusion. The second part of the volume outlines clinical identification and consequences of chimerism. Chapters in this section focus on the effects of chimerism on testing in relationship determination and forensics, prenatal genetic testing and screening, and blood and HLA typing. This part also reviews new data concerning matching donors and recipients for transplantation, while outlining the risks of transplantation, such as graft-vs-host disease and passenger lymphocyte syndrome.  Additionally, evidence on the role of chimerism in autoimmune disease and cancer is presented.  


Written by experts in the field, Chimerism: A Clinical Guide is a valuable resource for clinicians and researchers that will help guide patient management and stimulate investigative efforts.

• tetragametic chimerism
• dispermic chimerism
• fetomaternal microchimerism
• solid organ transplant
• hematopoietic stem cell transplant
• transfusion microchimerism

“The purpose is to provide a single source of the ‘current understanding of chimerism.’ This worthy objective is well met by this book. … This book would be of interest to anyone working in blood bank/transfusion services or molecular genetic testing, general anatomical pathologists and specialists in forensics, autoimmune and/or obstetrical pathology. … This is a fantastic book and a fascinating read. You will quickly get up to speed in an esoteric area which surprisingly impacts many aspects of medicine.” (Valerie L. Ng, Doody's Book Reviews, November, 2018)

• Department of Pathology, University of Colorado School of Medicine, Aurora, USA

  Nicole L. Draper

Nicole L. Draper, MD
University of Colorado School of Medicine
Department of Pathology
Aurora, CO 
USA

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