The Microbiome in Rheumatic Diseases and Infection

1. Front Matter

   Pages i-xxii

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2. Introductory Chapters

   1. Front Matter

      Pages 1-1

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   2. The Microbiome: Past, Present, and Future

      • Matthew L. Stoll

      Pages 3-11

   3. Methods for Microbiota Analysis: Sample Collection and Laboratory Methods

      • Saleh Ibrahim, Meriem Belheouane

      Pages 13-27

   4. Analytic Methods in Microbiome Studies

      • Philipp Rausch, Axel Künstner

      Pages 29-42

3. Immunogenetics of the Host Response to Infection

   1. Front Matter

      Pages 43-43

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   2. Immunodeficiency and Autoimmunity

      • T. Prescott Atkinson

      Pages 45-54

   3. Immunology of the Microbiome: Implications for Rheumatoid Arthritis and Other Autoimmune Diseases

      • Daniel M. Altmann, Catherine J. Reynolds, Rosemary J. Boyton

      Pages 55-62

   4. Animal Models of Rheumatoid Arthritis

      • David R. Webb

      Pages 63-72

4. Infectious Agents

   1. Front Matter

      Pages 73-73

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   2. Lyme Disease: Infectious and Noninfectious Features

      • Arthur Weinstein

      Pages 75-85

   3. Helicobacter pylori: Immune Responses and Gastric Autoimmunity

      • Maria Kaparakis-Liaskos, Mario M. D’Elios

      Pages 87-96

   4. Rheumatic Complications of Streptococcus pyogenes

      • Guliz Erdem, Edward L. Kaplan

      Pages 97-102

   5. Mollicutes: Mycoplasma pneumoniae

      • T. Prescott Atkinson

      Pages 103-111

   6. DNA Viruses in Autoimmune Rheumatic Diseases

      • Lazaros I. Sakkas, Dimitrios P. Bogdanos

      Pages 113-127

   7. RNA Viruses and Autoimmunity: A Short Overview

      • Massimo Galli, Giorgio Bozzi, Andrea Giacomelli

      Pages 129-138

   8. Autoimmunity and the Paradox of Chagas Disease

      • Ester Roffe, Philip M. Murphy

      Pages 139-147

5. The Role of Infectious Agents in Rheumatic Diseases

   1. Front Matter

      Pages 149-149

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   2. Macrophage Activation Syndrome

      • Esraa M. Eloseily, Randy Q. Cron

      Pages 151-182

   3. Rheumatoid Arthritis

      • Matthew L. Stoll, S. Louis Bridges Jr., Maria I. Danila

      Pages 183-199

This book discusses the role of the microbiome in rheumatic diseases and details its implications for patient treatment. Recently, with technological advances, there has been significant research into the microbiome. This has enabled us to more profoundly understand its role in our immune system maturation as well as the role played by microorganisms in autoimmunity and the deeply related rheumatic diseases. This book comprehensively explains the emerging microbiome research through the interrelationships of biomedical sciences, including: immunology, microbiology, bioinformatics, and, with special emphasis, the clinical aspect of rheumatology. It examines the interplay between infectious organisms and major autoimmune diseases, including rheumatoid arthritis, psoriatic arthritis, juvenile arthritis, systemic lupus erythematosus, and vasculitis, and explains how to apply that knowledge to diagnostic techniques and treatment decisions. The international team of expert authors provides insight into current therapies and future interventions specifically targeting the microbiota and explores the impact of our deeper understanding on enhancing personalized medicine. The Microbiome in Rheumatic Diseases and Infection is an essential resource for rheumatologists, pediatricians, internists, microbiologists, and critical care providers caring for children and adults with rheumatic diseases.

• microbiome
• immunogenetics
• bacterial disease
• rheumatic disease
• infection
• autoimmunity
• viral disease
• protozoal infections
• infectious diseases

• Faculty of Medicine, Cairo University, Cairo, Egypt

  Gaafar Ragab

• University of Alabama, Birmingham, USA

  T. Prescott Atkinson, Matthew L. Stoll

Gaafar Ragab, MD is Professor of Internal Medicine at Cairo University and Fellow of the American College of Rheumatology. He was previously Head of the Clinical Immunology and Rheumatology unit at Cairo University.

T. Prescott Atkinson, MD, PhD is Professor/ Director of the Division of Pediatric Allergy, Asthma & Immunology at The Children’s Hospital of Alabama.

Matthew L. Stoll, MD, PhD is Associate Professor in the Division of Pediatric Rheumatology at the University of Alabama at Birmingham.

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