Overview
- Nominated as an outstanding Ph.D. thesis by the University of Bristol, UK
- Presents an in-depth analysis of carbohydrate binding by proteins
- Offers new insights into non-covalent interactions in chemistry and biology
- Describes new methods to direct cellular development
Part of the book series: Springer Theses (Springer Theses)
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Table of contents (7 chapters)
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Front Matter
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Analysing Protein–Carbohydrate Interactions at the Molecular Level
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Front Matter
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Carbohydrate-Modified Materials for Tissue Engineering
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Front Matter
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Conclusions and Supplementary Information
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Front Matter
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Keywords
About this book
This book offers a clearly written and highly accessible account of two different aspects of carbohydrate chemistry. Carbohydrates are an essential component of life and have many important biological functions, but the details of how carbohydrates interact with other biomolecules to mediate biological signalling remain unclear. Firstly, this thesis details innovative methods to mine protein structural data to uncover new features of carbohydrate-based interactions. It also explains these findings using physical chemistry, specifically CH–pi interactions associated with the properties of the interacting partners.
Carbohydrates are also critical for tissue growth and development, yet are underexploited in the materials science that underpins much of regenerative medicine. As such, the second part of this thesis describes a diverse array of techniques ranging from synthetic chemistry and enzymatic synthesis to prepare a wide variety of carbohydrates, and materials chemistry to prepare glycosylated hydrogels, to cell biology to determine the effects on cellular development for tissue engineering applications.
Authors and Affiliations
About the author
Dr Kieran Hudson received a Master of Chemistry degree from the University of Oxford, UK in 2011. During his research there he developed an interest in the intersection of chemistry and biology, particularly in how small structural differences in biomolecules have substantial effects in nature. He developed this interest during his postgraduate research at the University of Bristol, UK, from where he obtained a PhD with a Faculty of Science Commendation in 2016. Dr Hudson is currently continuing his research as a postdoctoral fellow at the University of British Columbia, Canada.
Bibliographic Information
Book Title: Carbohydrate-Based Interactions at the Molecular and the Cellular Level
Authors: Kieran L. Hudson
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-3-319-77706-1
Publisher: Springer Cham
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: Springer International Publishing AG, part of Springer Nature 2018
Hardcover ISBN: 978-3-319-77705-4Published: 05 June 2018
Softcover ISBN: 978-3-030-08517-9Published: 14 December 2018
eBook ISBN: 978-3-319-77706-1Published: 28 May 2018
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XXIX, 198
Number of Illustrations: 49 b/w illustrations, 49 illustrations in colour
Topics: Carbohydrate Chemistry, Protein-Ligand Interactions, Theoretical and Computational Chemistry, Regenerative Medicine/Tissue Engineering, Physical Chemistry, Analytical Chemistry