Management of Infections in the Immunocompromised Host

1. Front Matter

   Pages i-xiv

   PDF

2. Phagocytes

   • Tyler Nygaard, Natalia Malachowa, Scott D. Kobayashi, Frank R. DeLeo

   Pages 1-25

3. T Cell Immunity

   • Shalu Sharma Kharkwal, Steven A. Porcelli

   Pages 27-41

4. B Cell Immunity

   • Lee Ann Garrett-Sinha

   Pages 43-54

5. Complement

   • Srinjoy Chakraborti, Sanjay Ram

   Pages 55-94

6. Antimicrobial Peptides

   • Srinjoy Chakraborti, Sanjay Ram

   Pages 95-113

7. Role of Deficits in Pathogen Recognition Receptors in Infection Susceptibility

   • Cristina Cunha, Samuel M. Gonçalves, Agostinho Carvalho

   Pages 115-131

8. Defects of Innate Immunity

   • Jana P. Lovell, Steven M. Holland

   Pages 133-149

9. T Cell Defects

   • Morna J. Dorsey, Morton J. Cowan

   Pages 151-165

10. Inflammatory Bowel Disease in Primary Immunodeficiencies

    • Abdul Aziz Elkadri, Aleixo Muise

    Pages 167-181

11. Infections in Cancer

    • Andrea J. Zimmer, Alison G. Freifeld

    Pages 183-194

12. Infections in Hematopoietic Stem Cell Transplant Recipients

    • Nikolaos G. Almyroudis

    Pages 195-230

13. Infections in Solid Organ Transplant Recipients

    • Shahid Husain, Coleman Rotstein

    Pages 231-242

14. Infections in HIV-Infected Patients

    • Onyema Ogbuagu, R. Douglas Bruce

    Pages 243-281

15. Infections in Patients with Autoimmune Diseases

    • Neil U. Parikh, Mark F. Sands, Stanley A. Schwartz

    Pages 283-295

16. Antibacterial and Antifungal Agents: The Challenges of Antimicrobial-Resistant Infections in Immunocompromised Hosts

    • Matthew W. McCarthy, Thomas Baker, Michael J. Satlin, Thomas J. Walsh

    Pages 297-315

17. Antiviral Treatment and Prophylaxis in Immunocompromised Hosts

    • Ella J. Ariza-Heredia, Firas El Chaer, Roy F. Chemaly

    Pages 317-337

18. Role of Immunoglobulin Therapy to Prevent and Treat Infections

    • Aspasia Katragkou, Emmanuel Roilides, Thomas J. Walsh

    Pages 339-358

19. Vaccines in the Immunocompromised Hosts

    • Paratosh Prasad, John Treanor

    Pages 359-374

20. Stem Cell Transplantation for Primary Immunodeficiency

    • Juliana Silva, Claire Booth, Paul Veys

    Pages 375-393

This book provides a comprehensive, state-of-the-art review of the concepts vital to a modern treatment of common and opportunistic infections in the immunocompromised host. Chapters are written by experts in the field, and include their views on gaps in the field and future directions of research. This book begins with an overview of the normally functioning immune system followed by a detailed discussion of the major primary immunodeficiencies. Specific chapters are dedicated to providing practical knowledge in the prevention and treatment of infections in specific immunocompromised patients, including those with cancer, transplant recipients, HIV infection, and autoimmune disorders. Emphasis is placed on diagnostic evaluation, antimicrobial selection that includes consideration of the threat of antimicrobial-resistant pathogens, and immunotherapy tailored to specific patients. Finally, dedicated chapters on stem cell transplantation for patients with primary immunodeficiencies,adoptive cellular immunotherapy, and gene therapy will provide readers with insight into these rapidly evolving and cutting edge therapies.
Management of Infections in the Immunocompromised Host is a valuable resource for infectious diseases specialists, immunologists, oncologists, hematologists, general physicians, students, researchers, and all other working with immunocompromised patients.

• Antibody deficiencies
• Bacterial infections
• Fungal infections
• Immunodeficiency
• Parasitic infections
• Viral infections
• infectious diseases

• Departments of Medicine and Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, USA

  Brahm H. Segal

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