Editors:
- Contains recent findings of nuclear-cytoplasmic transport systems through the nuclear envelope (NE) of eukaryotic cells
- Describes structure and role of nuclear pore complexes (NPCs) in trafficking macromolecules
- Analyzes mechanisms of nuclear-cytoplasmic transport in vitro and in vivo
Part of the book series: Nucleic Acids and Molecular Biology (NUCLEIC, volume 33)
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Table of contents (11 chapters)
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Front Matter
About this book
Editors and Affiliations
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Department of Biology, Temple University, Philadelphia, USA
Weidong Yang
About the editor
Weidong Yang, Ph.D. Dr. Yang is interested in exploring the molecular transport mechanisms in cells by using single-molecule tracking, super-resolution microscopy imaging and nanotechnology. His research laboratory is highly motivated to develop innovative research tools to meet the needs of solving challenging biological and biomedical problems, as they have done in the past and will be doing in the future. Currently, by developing and employing high-speed super-resolution microscopy techniques, Dr. Yang and his research team aim to solve two critical transport mechanisms involving three sub-cellular organelles in eukaryotic cells: nucleus, cytoplasm and primary cilium. Macromolecular trafficking among these compartments is suggested to be gated by two unique machineries. One is the nuclear pore complex (NPC) embedded in the nuclear envelope that mediates the bidirectional trafficking of proteins and RNAs between the cytoplasm and the nucleus; the other is the transition zone (TZ) located at the base of cilium that regulates the entry of membrane and cytosolic proteins into the cilium. Due to the challenges in elucidating kinetics and real-time transport routes for macromolecules through the sub-micrometer NPC or TZ in live cells, however, the fundamental gating mechanisms in either of these two machineries, remain obscure. Moreover, these transport mechanisms are not only the fundamental unanswered questions in cell biology, but also are closely associated with human diseases. For example, dysfunction of the nuclear transport through the NPC are linked to numerous human diseases including leukemias, cancers, and primary biliary cirrhosis. Also, defects in ciliary structure and/or function causes a variety of diseases (called ciliopathies) such as cystic kidney disease, nephronophthisis (NPHP), and retinitis pigmentosa. Thus, the fundamental knowledge of understanding the gating mechanisms in these transport systems is urgently needed to further develop therapeutics for the human diseases. In the Yang lab, they aim at employing and further developing high-speed super-resolution fluorescence microscopy techniques to unravel these fundamental transport mechanisms.
Bibliographic Information
Book Title: Nuclear-Cytoplasmic Transport
Editors: Weidong Yang
Series Title: Nucleic Acids and Molecular Biology
DOI: https://doi.org/10.1007/978-3-319-77309-4
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing AG, part of Springer Nature 2018
Hardcover ISBN: 978-3-319-77308-7Published: 11 August 2018
Softcover ISBN: 978-3-030-08425-7Published: 02 February 2019
eBook ISBN: 978-3-319-77309-4Published: 27 July 2018
Series ISSN: 0933-1891
Series E-ISSN: 1869-2486
Edition Number: 1
Number of Pages: VI, 274
Number of Illustrations: 4 b/w illustrations, 40 illustrations in colour
Topics: Nucleic Acid Chemistry, Applied Microbiology, Eukaryotic Microbiology, Evolutionary Biology