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Osteochondral Tissue Engineering

Challenges, Current Strategies, and Technological Advances

  • Book
  • © 2018

Overview

Editors:
  1. J. Miguel Oliveira

    1. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal

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  2. Sandra Pina

    1. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal

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  3. Rui L. Reis

    1. 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal

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  4. Julio San Roman

    1. Polymeric Nanomaterials and Biomaterials Department, Institute of Polymer Science and Technology, Spanish Council for Scientific Research (CSIC), Madrid, Spain

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  • Presents the latest developments and challenges as well as emerging technologies for the treatment of osteochondral lesions and defects
  • Highlights in vitro mimetic models, and in vivo studies using small and big animal models for OCTE
  • Presents the use of bioreactors and microfluidics for OCTE, including multi-chamber bioreactors
  • Discusses properties of stem cells and cell-based therapies with applications for OCTE

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1059)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-ix
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  2. Current Challenges in Osteochondral Repair and Regeneration: Trauma vs Disease

    1. Front Matter

      Pages 1-1
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    2. Advances for Treatment of Knee OC Defects

      • Marta Ondrésik, J. Miguel Oliveira, Rui L. Reis
      Pages 3-24

    3. Emerging Concepts in Treating Cartilage, Osteochondral Defects, and Osteoarthritis of the Knee and Ankle

      • Hélder Pereira, Ibrahim Fatih Cengiz, Carlos Vilela, Pedro L. Ripoll, João Espregueira-Mendes, J. Miguel Oliveira et al.
      Pages 25-62

    4. Osteoarthritis: Trauma vs Disease

      • Gema Jiménez, Jesús Cobo-Molinos, Cristina Antich, Elena López-Ruiz
      Pages 63-83

    5. Surgical Treatment Paradigms of Ankle Lateral Instability, Osteochondral Defects and Impingement

      • Hélder Pereira, Gwendolyn Vuurberg, Pietro Spennacchio, Jorge Batista, Pieter D’Hooghe, Kenneth Hunt et al.
      Pages 85-108

  3. Viscosupplementation

    1. Front Matter

      Pages 109-109
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    2. Clinical Management in Early OA

      • Rita Grazina, Renato Andrade, Ricardo Bastos, Daniela Costa, Rogério Pereira, José Marinhas et al.
      Pages 111-135

    3. Hyaluronic Acid

      • Hélder Pereira, Duarte Andre Sousa, António Cunha, Renato Andrade, J. Espregueira-Mendes, J. Miguel Oliveira et al.
      Pages 137-153

    4. Semi-IPN- and IPN-Based Hydrogels

      • Nicole Zoratto, Pietro Matricardi
      Pages 155-188

    5. Promising Biomolecules

      • Isabel Oliveira, Ana L. Carvalho, Hajer Radhouani, Cristiana Gonçalves, J. Miguel Oliveira, Rui L. Reis
      Pages 189-205

  4. Technological Advances in Osteochondral Tissue Engineering

    1. Front Matter

      Pages 207-207
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    2. Nanoparticles-Based Systems for Osteochondral Tissue Engineering

      • Isabel Oliveira, Sílvia Vieira, J. Miguel Oliveira, Rui L. Reis
      Pages 209-217

    3. Stem Cells for Osteochondral Regeneration

      • Raphaël F. Canadas, Rogério P. Pirraco, J. Miguel Oliveira, Rui L. Reis, Alexandra P. Marques
      Pages 219-240

    4. PRP Therapy

      • Ibrahim Fatih Cengiz, J. Miguel Oliveira, Rui L. Reis
      Pages 241-253

    5. Enhancing Biological and Biomechanical Fixation of Osteochondral Scaffold: A Grand Challenge

      • Maryam Tamaddon, Chaozong Liu
      Pages 255-298

  5. Osteochondral Tissue Engineering Approaches

    1. Front Matter

      Pages 299-299
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    2. Combination of Polymeric Supports and Drug Delivery Systems for Osteochondral Regeneration

      • Luis Rojo
      Pages 301-313

    3. Osteochondral Angiogenesis and Promoted Vascularization: New Therapeutic Target

      • Luis García-Fernández
      Pages 315-330

    4. Models of Disease

      • Gema Jiménez, Elena López-Ruiz, Cristina Antich, Carlos Chocarro-Wrona, Juan Antonio Marchal
      Pages 331-350
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Keywords

About this book

This book covers the most recent developments in the field of osteochondral tissue engineering (OCTE) and covers in detail the concepts and current challenges for bone and cartilage repair and regeneration. Specific topics include viscosupplementation, biologicals, tissue engineering approaches, in vitro and in vivo models, and technological advances with stem cells, bioreactors, and microfluidics. Osteochondral Tissue Engineering: Challenges, Current Strategies, and Technological Advances presents challenges and strategies in the field of osteochondral regeneration and serves as a core reference for biomedical engineering students and a wide range of established researchers and professionals working in orthopedics.

Editors and Affiliations

  • 3B’s Research Group – Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Barco, Guimarães, Portugal

    J. Miguel Oliveira, Sandra Pina, Rui L. Reis

  • Polymeric Nanomaterials and Biomaterials Department, Institute of Polymer Science and Technology, Spanish Council for Scientific Research (CSIC), Madrid, Spain

    Julio San Roman

About the editors

Dr. Joaquim Miguel Oliveira, BSc, PhD is a senior researcher “Investigador FCT 2012 and FCT 2015” at the Portuguese Government Associate Laboratory ICVS/3B´s-University of Minho. Currently, he is a volunteer lecturer at the Faculty of Medicine, U. Porto and Dept. of Polymer Eng., UM. Since 2001, he has been involved in the development of biomaterials from natural origin for tissue engineering and regenerative medicine. His research activities have been increasingly focused on nanomedicine, stem cells and 3D in vitro models of disease.

Dr. Sandra Pina, MsC, PhD, is an assistant researcherat the Portuguese Government Associate Laboratory ICVS/3B’s, University of Minho. Her research interests include bioresorbable calcium phosphate-based nanomaterials and ionic incorporated calcium phosphates nanocomposites for internal fracture fixation in traumatology, cranio-maxillofacial, spine and orthopaedic surgery.

Prof. Rui L. Reis, PhD, DSc, Hon. Causa MD (UGranada) is the Vice-Rector for R&D, Director of the 3B’s Research Group and of the ICVS/3B´s, of UMinho – Portugal. He is the CEO of the European Institute of Excellence on TERM, and the President-elect of Global TERMIS (Tissue Engineering & Regenerative Medicine International Society) and the editor-in-chief of the JTERM.

Prof. Julio San Roman, PhD, is director of Instituto de Ciencia y Tecnología de Polímeros CSIC. His scientific activities are centred in the study and development of polymer systems for biomedical applications, and specifically in tissue engineering, polymer drugs and drug delivery systems. 

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