Melanin-Concentrating Hormone and Sleep

1. Front Matter

   Pages i-xvi

   PDF

2. Neuroanatomical Structure of the MCH System

   • Jackson C. Bittencourt, Giovanne B. Diniz

   Pages 1-46

3. Projections of the MCH System to Structures Involved in the Regulation of Sleep and Wakefulness

   • Hyun Sook Lee

   Pages 47-55

4. The Role of Melanin-Concentrating Hormone in the Regulation of the Sleep/Wake Cycle: Sleep Promoter or Arousal Modulator?

   • Xiao-Bing Gao

   Pages 57-74

5. Optogenetic Control of the Melanin-Concentrating Hormone Expressing Neurons

   • Carlos Blanco-Centurion, Meng Liu, Priyattam Shiromani

   Pages 75-107

6. The Effects of Melanin-Concentrating Hormone on Neurotransmitter Systems Involved in the Generation and Maintenance of Wakefulness

   • Jaime M. Monti, Seithikurippu R. Pandi-Perumal, Pablo Torterolo

   Pages 109-120

7. Cannabinoids, Sleep, and the MCH System

   • Eric Murillo-Rodríguez, Daniela Morales-Lara, José Carlos Pastrana-Trejo, Lorena Macías-Triana, Karen Romero-Cordero, Miriel de-la-Cruz et al.

   Pages 121-130

8. MCH and Thermoregulation

   • Marco Luppi

   Pages 131-138

9. MCH, Sleep, and Neuroendocrine Functions

   • Carlos Eduardo Neves Girardi, Débora Cristina Hipólide, Vânia D’Almeida

   Pages 139-147

10. Melanin-Concentrating Hormone: Role in Nursing and Sleep in Mother Rats

    • Luciana Benedetto, Pablo Torterolo, Annabel Ferreira

    Pages 149-170

11. Melanin-Concentrating Hormone in Medical Conditions

    • Alicia Costa, Luciana Benedetto, Patricia Lagos, Jaime M. Monti, Pablo Torterolo

    Pages 171-193

12. MCH and Depression

    • Jessika Urbanavicius, Patricia Lagos, Ximena López, Pablo Torterolo, Cecilia Scorza

    Pages 195-206

13. MCH Receptor 1 Antagonists: Antidepressant/Anxiolytic Potential in Animal Models

    • Shigeyuki Chaki

    Pages 207-225

This book offers a compilation of papers on the role of melanin-concentrating hormone (MCH) in sleep, sleep disorders and neuroendocrine functions. Leading experts in sleep medicine, psychiatry and neuroendocrinology provide a broad perspective on the field, from the anatomical structure and physiology of the MCH system to the connection with other systems influencing sleep and diseases like anxiety and depression. The potential of MCHR-1 antagonists as anxiolytic/antidepressant drugs is also reviewed. The book will represent an interdisciplinary guide for sleep disorder specialists, sleep researchers, psychiatrists, neurologists, psychologists, and behavioral sleep medicine specialists. 

• Melanin-concentrating hormone
• Endocrine function
• Sleep disorder
• Hypersomnia
• Thermoregulation
• Pain control
• Maternal behavior

• Somnogen Canada Inc. , Toronto, Canada

  S. R. Pandi-Perumal

• Department of Physiology, School of Medicine, University of the Republic, Montevideo, Uruguay

  Pablo Torterolo

• Department of Pharmacology and Therapeutics, School of Medicine Clinics Hospital, University of the Republic, Montevideo, Uruguay

  Jaime M. Monti

S. R. Pandi-Perumal, MSc, is the President and Chief Executive Officer of Somnogen Canada Inc, a Canadian Corporation. He is a well-recognized sleep researcher, both nationally and internationally, and has authored over 200 publications. His general area of research interest includes sleep and biological rhythms. He is a well-known editor in the field of sleep medicine and has edited over 25 volumes dealing with various sleep-related topics. He received an honorable mention in the New York Times in 2004. The India International Friendship Society awarded him the prestigious Bharat Gaurav award on January 12, 2013. The Bharat Gaurav Award is usually recognition of a person who has made achievements in a particular field, which in turn will put a positive impact on the society at large.

Pablo Torterolo is Doctor of Medicine and Doctor of Neurosciences at the University of the Republic, Montevideo, Uruguay. He has completed post-doctoral studies at the University of Bologna and at the University of California, Los Angeles. He is currently Associate Professor of the Department of Physiology of the School of Medicine, University of the Republic. He is also Professor of the Basic Sciences Development Program (PEDECIBA) and Researcher the National Researchers' System. His research has been awarded with the Prize of the National Academy of Medicine and with the Elio García-Austt Award. His studies focus on the neurobiology and pathophysiology of sleep.

Jaime Monti is Doctor of Medicine at the University of the Republic, Uruguay. He has completed post-doctoral studies at the National Institute of Health, USA.  He is full Professor of Pharmacology and Therapeutic and the School of Medicine of the Republic University, Professor of the Basic Sciences Development Program (PEDECIBA) and Researcher the National Researchers' System. His research has been awarded with the Claude Bernard Prize (France government) and with the Schering Award for Basic Sleep Research.  He is an international recognized expert in the neuropharmacology of sleep and wakefulness, with more than a hundred of papers in this topic. 

Policies and ethics