Hallucinations in Psychoses and Affective Disorders

1. Front Matter

   Pages i-xiii

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2. Neurotransmission and Psychopathology

   1. Front Matter

      Pages 1-1

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   2. Substances of Abuse and Hallucinogenic Activity: The Dopaminergic Pathway - Focus on Cocaine and Amphetamine-type Stimulants

      • Matteo Lazzaretti, Gian Mario Mandolini, Alfredo Carlo Altamura, Paolo Brambilla

      Pages 3-16

   3. Substances of Abuse and Hallucinogenic Activity: The Serotoninergic Pathway - Focus on Classical Hallucinogens and Entactogens

      • Matteo Lazzaretti, Gian Mario Mandolini, Alfredo Carlo Altamura, Paolo Brambilla

      Pages 17-31

   4. Substances of Abuse and Hallucinogenic Activity: The Glutamatergic Pathway - Focus on Ketamine

      • Gian Mario Mandolini, Matteo Lazzaretti, Alfredo Carlo Altamura, Paolo Brambilla

      Pages 33-41

   5. Chronic Hallucinatory Disorder “an Equivalent” of Delusional Disorder

      • Massimo Carlo Mauri, Silvia Paletta, Chiara Di Pace, Chiara Rovera, Giorgio Marotta, Alfredo Carlo Altamura

      Pages 43-56

   6. Hallucinations in the Substance-Induced Psychosis

      • Massimo Carlo Mauri, Silvia Paletta, Chiara Di Pace

      Pages 57-83

   7. Hallucinatory Symptomatology in Major Psychoses (Schizophrenia and Bipolar Disorders)

      • Andrea Raballo, Michele Poletti, Mads Gram Henriksen

      Pages 85-97

   8. Hallucinations in Neurological Disorders

      • Alessio Di Fonzo, Edoardo Monfrini, Paola Basilico, Andrea Arighi

      Pages 99-130

3. Genetics and Neuroimaging

   1. Front Matter

      Pages 131-131

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   2. Genetic Basis of Auditory Verbal Hallucinations in Schizophrenia

      • Anushree Bose, Venkataram Shivakumar, Ganesan Venkatasubramanian

      Pages 133-147

   3. Imaging Genetics of Hallucinations

      • Jacqueline Mayoral-van Son, Julio Sanjuan, Benedicto Crespo-Facorro

      Pages 149-157

   4. Dysconnectivity in Hallucinations

      • Branislava Ćurčić-Blake, Josselin Houenou, Renaud Jardri

      Pages 159-171

4. Treatment

   1. Front Matter

      Pages 173-173

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   2. Translating Neurocognitive Models of Auditory Verbal Hallucinations in Schizophrenia into Novel Therapeutic Interventions

      • Natasza Orlov, Jane Garisson, Paul Allen

      Pages 175-190

   3. Innovative Approaches to Hallucinations in Psychosis and Affective Disorders: A Focus on Noninvasive Brain Stimulation Interventions

      • Bernardo Dell’Osso, M. Carlotta Palazzo, Alfredo Carlo Altamura

      Pages 191-208

This book presents state of the art knowledge on the psychopathology, clinical symptomatology, biology, and treatment of hallucinations in patients with psychoses and affective disorders. The opening section describes and examines the origins of the hallucinatory symptoms associated with schizophrenia, bipolar disorders, and drug- or substance-induced psychoses. In addition, progress in understanding of hallucinations in children and adolescents and chronic hallucinatory disorder is reviewed, and the value of a Research Domain Criteria approach in elucidating the emergence of auditory hallucinations is explained. The biological basis of hallucinations is then closely scrutinized with reference to recent genetic research, neurochemical studies, and functional and structural neuroimaging data. Outcomes of a meta-analysis of diffusion tensor imaging studies regarding the association between white matter integrity and auditory verbal hallucinations are highlighted. The closing chapters focus on the roles of drug treatment and electric and magnetic brain stimulation techniques. The book will be of wide interest to psychiatrists and clinical psychologists.

• voices
• disperceptions
• mood disorders
• schizophrenia
• hallucinatory disorders

“This is a thorough, detailed, and well-written book that helps readers get an in-depth understanding of the nature of hallucinations in psychiatry. It is well organized, and presents the information in a digestible form, which would otherwise be difficult to find in a consolidated source such as this.” (Jeff K Abbott, Doody's Book Reviews, March, 15, 2019)

• Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, University of Milan, Milan, Italy

  Paolo Brambilla, Massimo Carlo Mauri, Alfredo Carlo Altamura

Paolo Brambilla, M.D., Specialist in Psychiatry, Ph.D. in Neuropharmacology and Neurophysiology, is currently Associate Professor of Psychiatry at the University of Milan, Adjunct Associate Professor of Psychiatry at UT Houston, USA, Chair of the EPA Neuroimaging Section and Co-Editor in Chief of the Journal of Affective Disorders.  Since 2005 he has coordinated research studies at the Developmental Psychopathology Research Unit at the IRCCS Scientific Institute “E. Medea”. Prof. Brambilla is a member of the Scientific Boards of the “Imago 7” Foundation, which manages the only MR scanner at ultra high field (7 Tesla) for human research in Italy. He is the recipient of several international scientific honors, of national and international grants, and is the author or co-author of more than 190 original papers published in international peer-reviewed journals.

Massimo Carlo Mauri, M.D., Specialist in Psychiatry, Ph.D. in Psychiatry and Behavioural Sciences, Psychiatrist, Department of Clinical Psychiatry, IRCCS Ospedale Maggiore Policlinico Milano. Chief of the Clinical Psychopharmacology Unit, he is member of several professional societies: Italian Society of Psychiatry, European College of Neuropsychopharmacology, International Membership American Psychiatric Association, and WPA Section on Pharmacopsychiatry. He published more than 300  papers in national and international journals on Psychopharmacology, Pharmacokinetics, Clinical and Biological Psychiatry and acts as a Reviewer for several international journals. 

A. Carlo Altamura is Professor and Chair, Department of Neuroscience and Mental Health, IRCCS Foundation Ca’ Granda, Ospedale Maggiore Policlinico of Milan, University of Milan, Director of Residency of Psychiatry. He is President of the Italian Society of Neuropsychopharmacology, Past President of the Italian Chapter of the International Society of Bipolar Disorders, and President of the Italian Society of Depressive Disorders. Author of 250 publications cited in PubMed.

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