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  • © 2018

Metabolic Interaction in Infection

  • State-of-the art guide of metabolism focused on host-pathogen interactions
  • Characterization of the emerging role of immunometabolism during infections
  • Comparative description of microbial auxotrophy and host cell metabolic rewiring by pathogens;
  • Current status and future perspectives on the clinical application of cell metabolism evaluation in infectious contexts

Part of the book series: Experientia Supplementum (EXS, volume 109)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-viii
  2. A Guide of Metabolism During Host–Pathogen Interactions

    1. Front Matter

      Pages 1-1
    2. Cellular Metabolism at a Glance

      • Inês Mesquita, Fernando Rodrigues
      Pages 3-27
    3. Interaction Between Nutrition and Metabolism

      • Stella Maria Barrouin-Melo, Yadira Alejandra Morejón Terán, Johanna Anturaniemi, Anna Katrina Hielm-Björkman
      Pages 29-114
    4. Interplay Between Metabolic Sensors and Immune Cell Signaling

      • Prashant Chauhan, Arup Sarkar, Bhaskar Saha
      Pages 115-196
    5. Alterations on Cellular Redox States upon Infection and Implications for Host Cell Homeostasis

      • Inês Mesquita, Baptiste Vergnes, Ricardo Silvestre
      Pages 197-220
    6. Mitochondrial Bioenergetics and Dynamics During Infection

      • Cynthia Soultawi, Yasmina Fortier, Calaiselvy Soundaramourty, Jérôme Estaquier, Mireille Laforge
      Pages 221-233
    7. Computational Systems Biology of Metabolism in Infection

      • Müberra Fatma Cesur, Ecehan Abdik, Ünzile Güven-Gülhan, Saliha Durmuş, Tunahan Çakır
      Pages 235-282
    8. Metabolomic-Based Methods in Diagnosis and Monitoring Infection Progression

      • Miguel Fernández-García, David Rojo, Fernanda Rey-Stolle, Antonia García, Coral Barbas
      Pages 283-315
  3. Microbial Metabolic Adaptation and Pathogen Rewiring of Host Cell Metabolism During Infection

    1. Front Matter

      Pages 317-317
    2. Metabolic Host Response to Intracellular Infections

      • Catarina M. Ferreira, Ana Margarida Barbosa, Inês M. Pereira, Egídio Torrado
      Pages 319-350
    3. Protozoan Parasite Auxotrophies and Metabolic Dependencies

      • Elodie Gazanion, Baptiste Vergnes
      Pages 351-375
    4. Viral Manipulation of the Host Metabolic Network

      • Inês Mesquita, Jérôme Estaquier
      Pages 377-401
    5. Metabolic Regulation of Innate Immunity to Fungal Infection

      • Cláudia S. Rodrigues, Cláudia F. Campos, Cristina Cunha, Agostinho Carvalho
      Pages 403-420
    6. Metabolic Crosstalk Between Host and Parasitic Pathogens

      • Diana Moreira, Jérôme Estaquier, Anabela Cordeiro-da-Silva, Ricardo Silvestre
      Pages 421-458
    7. Microbiome and Gut Dysbiosis

      • José E. Belizário, Joel Faintuch
      Pages 459-476

About this book

This book focuses on host–pathogen interactions at the metabolic level. It explores the metabolic requirements of the infectious agents, the microbial metabolic pathways that are dedicated to circumvent host immune mechanisms as well as the molecular mechanisms by which pathogens hijack host cell metabolism for their own benefit. Finally, it provides insights on the possible clinical and immunotherapeutic applications, as well as on the available experimental and analytical methods. The contributions break new ground in understanding the metabolic crosstalk between host and pathogen.

Editors and Affiliations

  • Life and Health Sciences Research Institute, University of Minho, Braga, Portugal

    Ricardo Silvestre, Egídio Torrado

About the editors

Ricardo Silvestre is Principal Investigator at the Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Portugal. His research interest is to integrate the study of basic molecular and cellular mechanisms to develop a greater understanding of the immune-metabolic interface in innate immune cells. He addresses how the modifications of host cell metabolism and bioenergetics arising during inflammatory or infectious processes impact the immune functions of monocytes/macrophage and dendritic cells and the further consequences to tissue homeostasis with the objective of developing new approaches to prevention and treatment. 

Egídio Torrado is Assistant Researcher at the Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Portugal. His research is focused on the mechanisms that regulate the protective immune response to Mycobacterium tuberculosis
both during the innate and chronic phases of the infection. The emphasis of his work is on cytokines and the maintenance of the T cell response and the development of pathological consequences to the host.

Bibliographic Information

  • Book Title: Metabolic Interaction in Infection

  • Editors: Ricardo Silvestre, Egídio Torrado

  • Series Title: Experientia Supplementum

  • DOI: https://doi.org/10.1007/978-3-319-74932-7

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG, part of Springer Nature 2018

  • Hardcover ISBN: 978-3-319-74931-0Published: 18 April 2018

  • Softcover ISBN: 978-3-030-09108-8Published: 03 January 2019

  • eBook ISBN: 978-3-319-74932-7Published: 06 April 2018

  • Series ISSN: 1664-431X

  • Series E-ISSN: 2504-3692

  • Edition Number: 1

  • Number of Pages: VIII, 476

  • Number of Illustrations: 2 b/w illustrations, 43 illustrations in colour

  • Topics: Molecular Medicine, Biochemistry, general, Medical Microbiology

Buy it now

Buying options

eBook USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 159.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access