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  • © 2018

Drug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions

  • A definitive resource on food-drug and herb-drug interactions
  • Brand new chapter on in vitro modeling of drug interactions
  • Fills a gap in the medical literature on the complex relations between acute infection, inflammation, and the risk of drug interactions

Part of the book series: Infectious Disease (ID)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xvi
  2. Introduction to Drug-Drug Interactions

    • Manjunath P. Pai, Jennifer J. Kiser, Paul O. Gubbins, Keith A. Rodvold
    Pages 1-13
  3. Mechanisms of Drug Interactions I: Absorption, Metabolism, and Excretion

    • David M. Burger, Lindsey H. M. te Brake, Rob E. Aarnoutse
    Pages 15-47
  4. Mechanisms of Drug Interactions II: Transport Proteins

    • Darren Michael Moss, Marco Siccardi, Catia Marzolini
    Pages 49-85
  5. Drug-Food Interactions

    • Eric Wenzler, Kelly Sprandel-Harris, Keith A. Rodvold
    Pages 87-162
  6. Drug-Cytokine Interactions

    • Kerry B. Goralski, Matthew A. Ladda, Jenna O. McNeil
    Pages 163-204
  7. Interactions Between Herbs and Anti-infective Medications

    • Surulivelrajan Mallayasamy, Scott R. Penzak
    Pages 205-242
  8. In Vitro Modeling of Drug-Drug Interactions

    • Grant T. Generaux
    Pages 243-257
  9. Probe Cocktail Studies

    • Anne N. Nafziger, Joseph S. Bertino Jr
    Pages 259-284
  10. Design and Data Analysis in Drug Interaction Studies

    • David E. Nix, Keith Gallicano
    Pages 285-315
  11. Back Matter

    Pages 317-326

About this book

The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes – “Mechanisms and Models of Drug Interactions” and “Antimicrobial Drug Interactions”.

This volume, “Mechanisms and Models of Drug Interactions,” delivers a text that enhances clinical knowledge of the complex mechanisms, risks, and consequences of drug interactions associated with antimicrobials, infection, and inflammation.  The book provides a comprehensive review of basic clinical pharmacology with a focus on metabolism and transporter-mediated drug interactions. The chapters address materials that cannot be retrieved easily in the medical literature, including materials focused on the complex interrelationship of acute infection, inflammation, and the risk of drug interactions in the Drug-Cytokine chapter. The Food-Drug and Herb-Drug interactions chapters remain definitive resources. A new chapter on in vitro modeling of drug interactions isincluded along with updates on design and data analysis of clinical drug interaction studies. Authoritative discussion of models for regulatory decision-making on drug-drug interactions provides the necessary framework to aid antimicrobial drug development. This concise review of the mechanisms and models of drug interactions provides important insights to health care practitioners as well as scientists in drug development.

Editors and Affiliations

  • College of Pharmacy, University of Michigan, Ann Arbor, USA

    Manjunath P. Pai

  • Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, USA

    Jennifer J. Kiser

  • Division of Pharmacy Practice and Administration, UMKC School of Pharmacy at MSU, Springfield, USA

    Paul O. Gubbins

  • College of Pharmacy and Medicine, University of Illinois at Chicago, Chicago, USA

    Keith A. Rodvold

About the editors

Manjunath P. Pai, College of Pharmacy, University of Michigan, Ann Arbor, MI 

Jennifer J. Kiser, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO 

Paul O. Gubbins, School of Pharmacy, University of Missouri-Kansas City, Springfield, MO

Keith A. Rodvold, University of Illinois, College of Pharmacy and Medicine, Chicago, IL 

Bibliographic Information

  • Book Title: Drug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions

  • Editors: Manjunath P. Pai, Jennifer J. Kiser, Paul O. Gubbins, Keith A. Rodvold

  • Series Title: Infectious Disease

  • DOI: https://doi.org/10.1007/978-3-319-72422-5

  • Publisher: Humana Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing AG 2018

  • Hardcover ISBN: 978-3-319-72421-8Published: 19 March 2018

  • Softcover ISBN: 978-3-030-10198-5Published: 01 February 2019

  • eBook ISBN: 978-3-319-72422-5Published: 05 March 2018

  • Edition Number: 4

  • Number of Pages: XVI, 326

  • Number of Illustrations: 3 b/w illustrations, 5 illustrations in colour

  • Topics: Pharmaceutical Sciences/Technology, Infectious Diseases, Pharmacy

Buy it now

Buying options

eBook USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 129.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 129.00
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access