Recurrent Implantation Failure

1. Front Matter

   Pages i-xiii

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2. Signaling Between Embryo and Endometrium: Normal Implantation

   • Chelsea Fox, Bruce A. Lessey

   Pages 1-19

3. Embryo and Endometrial Synchrony in Implantation Failure

   • Jason M. Franasiak, Richard T. Scott

   Pages 21-31

4. Spermatogenesis: Fertile Ground for Contributing to Recurrent Implantation Failure?

   • Sorena Keihani, Jeremy B. Myers, James M. Hotaling

   Pages 33-58

5. Embryonic Factors Associated with Recurrent Implantation Failure

   • Daniel J. Kaser, Catherine Racowsky

   Pages 59-75

6. The Genetics of Pregnancy Failure

   • Eric J. Forman, Nathan Treff, Rebekah S. Zimmerman

   Pages 77-91

7. Immune Factors in Recurrent Implantation Failure

   • Diana Alecsandru, Juan A. Garcia-Velasco

   Pages 93-102

8. Stress and Implantation Failure

   • Jeffrey L. Deaton, Bonnie Patel, Erika Johnston-MacAnanny, Jie Yu, Shannon D. Whirledge, Alexandra Wilson et al.

   Pages 103-124

9. Hematologic Disease in Implantation Failure

   • Shelby A. Neal, Jason M. Franasiak, Richard T. Scott

   Pages 125-134

10. Endocrine Causes of Implantation Failure

    • Scott Morin, Baris Ata, Emre Seli

    Pages 135-152

11. Anatomic Abnormalities and Recurrent Implantation Failure

    • Jeffrey M. Goldberg, Julian Gingold, Natalia Llarena

    Pages 153-174

12. Microbiome in Embryonic Implantation and Implantation Failure

    • Jason M. Franasiak, Inmaculada Moreno, Carlos Simon

    Pages 175-195

13. Psychosocial Implications of Recurrent Implantation Failure

    • Andrea Mechanick Braverman, Keren Sofer

    Pages 197-210

14. Back Matter

    Pages 211-215

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This unique text discusses the wide range of causes and pathophysiologic conditions contributing to recurrent implantation failure (RIF) and the current treatment approaches to best approach this challenging patient population. Beginning with a presentation of the mechanism of normal implantation, the physiologic synchrony between embryo and endometrium, and the roles of both gametes and embryos in RIF, the book then examines the various genetic, immune and environmental factors involved. Abnormalities of the hematologic and endocrine system, as well as those of the anatomy and microbiome, are described in detail. Last but no less important, the psychological stress and treatment of patients experiencing RIF is discussed. 



Assisted reproductive technology (ART) success has increased substantially over the past three decades. However, despite these advances, recurrent implantation failure is still a common issue confronting patients and clinicians, and RIF represents one of the greatest challenges in ART and remains a source of frustration and disappointment for patients, clinicians, and researchers involved in the process. Providing an in-depth investigation into the pathophysiology and biological mechanisms of RIF and its clinical management, this will be an excellent resource for reproductive endocrinologists and infertility specialists. 

• Anatomic abnormality
• ART
• Assisted hatching
• Assisted reproductive technology
• Blastocyst transfer
• Embryo
• Endometrial synchrony
• Environmental factor
• Gamete
• Immune factors
• Microbiome
• Oocyte
• Pregnancy loss
• Preimplantation genetic diagnosis
• Recurrent implant failure
• RIF
• Sperm

• Reproductive Medicine Associates of NJ, Thomas Jefferson University, Basking Ridge, USA

  Jason M. Franasiak, Richard T. Scott Jr.

Jason M. Franasiak, MD, TS (ABB), Assistant Professor, Sidney Kimmel Medical School, Thomas Jefferson University, Reproductive Medicine Associates of New Jersey, Basking Ridge, NJ, USA

Richard T. Scott, MD, HCLD/ALD (ABB), Professor, Sidney Kimmel Medical School, Thomas Jefferson University, Reproductive Medicine Associates of New Jersey, Basking Ridge, NJ, USA

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