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5-HT2A Receptors in the Central Nervous System

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  • © 2018

Overview

Editors:
  1. Bruno P. Guiard

    1. Faculté de Pharmacie, Université Paris Sud, Université Paris-Saclay, Chatenay-Malabry, France

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  2. Giuseppe Di Giovanni

    1. Department of Physiology and Biochemistry, University of Malta, Msida MSD, Malta

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    You can also search for this editor in PubMed   Google Scholar

  • Contains the latest information on the subject of neuropsychiatric disorders in relation to 5-HT2A
  • Reflects on various factors involved in normal and pathological behavior
  • Provides practical suggestions?

Part of the book series: The Receptors (REC, volume 32)

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-xii
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  2. Properties and Distribution of the 5-HT2AR

    1. Front Matter

      Pages 1-1
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    2. Pharmacological Analysis in Favour of a Physiological Role for the Constitutive Activity of 5-HT2A Receptors in Learning

      • Philippe De Deurwaerdère, Guillaume Drutel, Giuseppe Di Giovanni
      Pages 3-29

    3. βArrestins: Ligand-Directed Regulators of 5-HT2A Receptor Trafficking and Signaling Events

      • Cullen L. Schmid, Laura M. Bohn
      Pages 31-55

    4. 5-HT2A Receptor Heterodimerization

      • Sylwia Łukasiewicz, Ewa Błasiak, Marta Dziedzicka-Wasylewska
      Pages 57-66

    5. Brain Distribution

      • Cristiano Bombardi
      Pages 67-84

    6. PET Imaging of the 5-HT2A Receptor System: A Tool to Study the Receptor’s In Vivo Brain Function

      • Matthias M. Herth, Gitte M. Knudsen
      Pages 85-134

  3. 5-HT2AR Related Brain Functions

    1. Front Matter

      Pages 135-135
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    2. Serotonergic Receptor 5-HT2A in the Cardiosympathovagal System

      • M. Kermorgant, A. Pavy-Le Traon, J. M. Senard, D. N. Arvanitis
      Pages 137-145

    3. Crosstalk Between 5-HT2A and mGlu2 Receptors: Implications in Schizophrenia and Its Treatment

      • José L. Moreno, Javier González-Maeso
      Pages 147-189

    4. Schizophrenia

      • Anna Castañé, Albert Adell
      Pages 191-204

    5. Role of Serotonin-2A Receptors in Pathophysiology and Treatment of Depression

      • Lucia Moravčíková, Kristína Csatlósová, Barbora Ďurišová, Katarína Ondáčová, Michaela Pavlovičová, Ľubica Lacinová et al.
      Pages 205-230

    6. Brain Circuits Regulated by the 5-HT2A Receptor: Behavioural Consequences on Anxiety and Fear Memory

      • L. Moulédous, P. Roullet, Bruno P. Guiard
      Pages 231-258

    7. 5-HT2A/2B/2C Receptors, Memory and Therapeutic Targets

      • Alfredo Meneses, Rossana Nieto-Vera, Rosa María Anaya-Jiménez
      Pages 259-271

    8. 5-HT2A Receptors in the Basal Ganglia

      • Cristina Miguelez, Teresa Morera-Herreras, Philippe De Deurwaerdère
      Pages 273-310

    9. The Involvement of 5-HT2A Receptor in the Regulation of Sleep and Wakefulness, and the Potential Therapeutic Use of Selective 5-HT2A Receptor Antagonists and Inverse Agonists for the Treatment of an Insomnia Disorder

      • Jaime M. Monti, Seithikurippu R. Pandi Perumal, D. Warren Spence, Pablo Torterolo
      Pages 311-337

    10. 5-HT2A Receptors and Pain

      • Christine Courteix, Amandine Dupuis, Pierre-Yves Martin, Benoit Sion
      Pages 339-352

    11. 5-HT2A Receptors in Eating Disorders

      • Philip Gorwood, Laurence Lanfumey, Odile Viltart, Nicolas Ramoz
      Pages 353-373

    12. Role of Serotonin2A (5-HT2A) Receptors in Epilepsy

      • Vincenzo Crunelli, Marcello Venzi, Philippe De Deurwaerdère, Giuseppe Di Giovanni
      Pages 375-394

    13. 5-HT2A Receptors and BDNF Regulation: Implications for Psychopathology

      • Minal Jaggar, Vidita A. Vaidya
      Pages 395-438
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Keywords

About this book

5-HT2A receptors are G-protein coupled receptors that are widely distributed throughout the brain, most notably on neuronal and glial cells. 5-HT2A receptors have been implicated in various central physiological functions including mood regulation, memory, sleep, nociception, eating, and reward behaviors, and they are also believed to control the cardiovascular system. This  book provides a comprehensive overview of these receptors including sections on their properties and distribution, approaches for their study, their role in a number of brain functions and diseases, and their role as therapeutic targets. ​

Editors and Affiliations

  • Faculté de Pharmacie, Université Paris Sud, Université Paris-Saclay, Chatenay-Malabry, France

    Bruno P. Guiard

  • Department of Physiology and Biochemistry, University of Malta, Msida MSD, Malta

    Giuseppe Di Giovanni

About the editors

Giuseppe Di Giovanni is Professor of Human Physiology, University of Malta, Malta. He is the President of the Malta Neuroscience Network and the Vice-President of the Mediterranean Neuroscience Society. He is the Editor in  Chief of Journal Neuroscience Methods by Elsevier and the Editor for the book series The Receptor by Springer/Nature. His research  focuses on the pathophysiology of the monoaminergic systems in different neuropsychiatric disorders, such as Parkinson's disease, depression, drug of abuse and epilepsy.

Bruno Guiard is Associate Professor in Pharmacology, University of Paris XI, France. He is the author of several book chapters/reviews on the mechanisms of action of antidepressant drugs. He also took part in the edition of books on the neurobiology of mood. His research deals with the influence of astroglial cells in the regulation of serotonergic neurotransmission and the identification of new pharmacological targets for the treatment of various neuropsychiatric diseases. 


Bibliographic Information

  • Book Title: 5-HT2A Receptors in the Central Nervous System

  • Editors: Bruno P. Guiard, Giuseppe Di Giovanni

  • Series Title: The Receptors

  • DOI: https://doi.org/10.1007/978-3-319-70474-6

  • Publisher: Humana Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG 2018

  • Hardcover ISBN: 978-3-319-70472-2Published: 22 February 2018

  • Softcover ISBN: 978-3-319-88945-0Published: 06 June 2019

  • eBook ISBN: 978-3-319-70474-6Published: 14 February 2018

  • Series ISSN: 1048-6909

  • Series E-ISSN: 2524-6488

  • Edition Number: 1

  • Number of Pages: XII, 446

  • Number of Illustrations: 46 b/w illustrations, 23 illustrations in colour

  • Topics: Neurosciences, Neurobiology

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