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Sex and Gender Factors Affecting Metabolic Homeostasis, Diabetes and Obesity

  • Book
  • © 2017

Overview

Editors:
  1. Franck Mauvais-Jarvis

    1. Department of Medicine, Section of Endocrinology and Metabolism, Tulane University Health Sciences Center, School of Medicine, New Orleans, USA

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  • The first book to discuss gender biology and sex differences in endocrinology research and drug discovery for metabolic diseases
  • Expands on presentations and discussions at the March 2017 Keystone Symposium on this same topic
  • Foreword by Janine Clayton, MD, Director of NIH Office of Research on Women's Health
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1043)

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Table of contents (28 chapters)

  1. Front Matter

    Pages i-xxii
    Download chapter PDF

  2. Sex Differences in Diabetes and Obesity

    1. Front Matter

      Pages 1-1
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    2. Epidemiology of Gender Differences in Diabetes and Obesity

      • Franck Mauvais-Jarvis
      Pages 3-8

    3. Sex Differences in Body Composition

      • Miriam A. Bredella
      Pages 9-27

    4. Cellular Mechanisms Driving Sex Differences in Adipose Tissue Biology and Body Shape in Humans and Mouse Models

      • Kalypso Karastergiou, Susan K. Fried
      Pages 29-51

    5. Men Are from Mars, Women Are from Venus: Sex Differences in Insulin Action and Secretion

      • Ananda Basu, Simmi Dube, Rita Basu
      Pages 53-64

    6. The Role of Sex and Sex Hormones in Regulating Obesity-Induced Inflammation

      • Mita Varghese, Cameron Griffin, Kanakadurga Singer
      Pages 65-86

    7. Sex Differences in Leptin Control of Cardiovascular Function in Health and Metabolic Diseases

      • Eric J. Belin de Chantemèle
      Pages 87-111

    8. Sex Effects at the Ramparts: Nutrient- and Microbe-Mediated Regulation of the Immune-Metabolic Interface

      • Nyrie Israelian, Jayne S. Danska
      Pages 113-140

    9. Sexual Dimorphism and Estrogen Action in Mouse Liver

      • Sara Della Torre, Federica Lolli, Paolo Ciana, Adriana Maggi
      Pages 141-151

    10. Sex Differences in Muscle Wasting

      • Lindsey J. Anderson, Haiming Liu, Jose M. Garcia
      Pages 153-197

    11. Origins and Functions of the Ventrolateral VMH: A Complex Neuronal Cluster Orchestrating Sex Differences in Metabolism and Behavior

      • William C. Krause, Holly A. Ingraham
      Pages 199-213

  3. Role of Estrogens in Metabolic Homeostasis

    1. Front Matter

      Pages 215-215
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    2. Menopause, Estrogens, and Glucose Homeostasis in Women

      • Franck Mauvais-Jarvis
      Pages 217-225

    3. Role of Estrogens in the Regulation of Liver Lipid Metabolism

      • Brian T. Palmisano, Lin Zhu, John M. Stafford
      Pages 227-256

    4. The Role of Skeletal Muscle Estrogen Receptors in Metabolic Homeostasis and Insulin Sensitivity

      • Andrea L. Hevener, Zhenqi Zhou, Brian G. Drew, Vicent Ribas
      Pages 257-284

    5. Estrogens and Body Weight Regulation in Men

      • Katya B. Rubinow
      Pages 285-313

    6. Estradiol Regulation of Brown Adipose Tissue Thermogenesis

      • Ismael González-García, Manuel Tena-Sempere, Miguel López
      Pages 315-335

    7. Brain Estrogens and Feeding Behavior

      • Yong Xu
      Pages 337-357

    8. Sex Differences and Role of Estradiol in Hypoglycemia-Associated Counter-Regulation

      • Karen P. Briski, Hussain N. Alhamami, Ayed Alshamrani, Santosh K. Mandal, Manita Shakya, Mostafa H. H. Ibrahim
      Pages 359-383
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Keywords

About this book

The book provides a reference for years to come, written by world-renowned expert investigators studying sex differences, the role of sex hormones, the systems biology of sex, and the genetic contribution of sex chromosomes to metabolic homeostasis and diseases. In this volume, leaders of the pharmaceutical industry present their views on sex-specific drug discovery. Many of the authors presented at the Keystone Symposium on “Sex and gender factors affecting metabolic homeostasis, diabetes and obesity” to be held in March 2017 in Lake Tahoe, CA. This book will generate new knowledge and ideas on the importance of gender biology and medicine from a molecular standpoint to the population level and to provide the methods to study them. It is intended to be a catalyst leading to gender-specific treatments of metabolic diseases.


There are fundamental aspects of metabolic homeostasis that are regulated differently in males
and females, and influence boththe development of diabetes and obesity and the response to pharmacological intervention. Still, most preclinical researchers avoid studying female rodents due to the added complexity of research plans. The consequence is a generation of data that risks being relevant to only half of the population. This is a timely moment to publish a book on sex differences in diseases as NIH leadership has asked scientists to consider sex as a biological variable in preclinical research, to ensure that women get the same benefit of medical research as men. 

Editors and Affiliations

  • Department of Medicine, Section of Endocrinology and Metabolism, Tulane University Health Sciences Center, School of Medicine, New Orleans, USA

    Franck Mauvais-Jarvis

About the editor

Franck Mauvais-Jarvis, MD, PhD, is Director of the Diabetes Discovery Research & Gender Medicine Laboratory, and Professor of Medicine, Section of Endocrinology and Metabolism, Tulane University Health Sciences Center, New Orleans, Louisiana, USA.

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