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Marburg- and Ebolaviruses

From Ecosystems to Molecules

  • Book
  • © 2017

Overview

Editors:
  1. Elke Mühlberger

    1. Boston University School of Medicine , Boston, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Lisa L. Hensley

    1. NIAID, National Institutes of Health NIAID, Frederick, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Jonathan S. Towner

    1. Centers for Disease Control & Prevention, Atlanta, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Summarizes the latest studies on intracellular events during filovirus infection
  • Focuses on mechanisms of viral entry and receptor binding, assembly of the viral particles inside the cell, and the use of reverse genetic systems
  • Explains recent advances in our understnding of filovirus disease, pathology in the NHP model, and the development of new small animal models to study filovirus infectionn
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 411)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Maintenance in Nature and Spillover: Ecology, Outbreaks and Clinical Management

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Filovirus Research: How it Began

      • Werner Slenczka
      Pages 3-21

    3. Ecology of Filoviruses

      • Brian R. Amman, Robert Swanepoel, Stuart T. Nichol, Jonathan S. Towner
      Pages 23-61

    4. West Africa 2013 Ebola: From Virus Outbreak to Humanitarian Crisis

      • Daniel G. Bausch
      Pages 63-92

    5. Clinical Management of Ebola Virus Disease Patients in Low-Resource Settings

      • Armand Sprecher, Michel Van Herp, Pierre E. Rollin
      Pages 93-113

    6. Clinical Management of Patients with Ebola Virus Disease in High-Resource Settings

      • G. Marshall Lyon, Aneesh K. Mehta, Bruce S. Ribner
      Pages 115-137

  3. Disease: Pathogenesis and Protection

    1. Front Matter

      Pages 139-139
      Download chapter PDF

    2. Ebola Virus Disease in Humans: Pathophysiology and Immunity

      • César Muñoz-Fontela, Anita K. McElroy
      Pages 141-169

    3. Nonhuman Primate Models of Ebola Virus Disease

      • Richard S. Bennett, Louis M. Huzella, Peter B. Jahrling, Laura Bollinger, Gene G. Olinger Jr, Lisa E. Hensley
      Pages 171-193

    4. Small Animal Models for Studying Filovirus Pathogenesis

      • Satoko Yamaoka, Logan Banadyga, Mike Bray, Hideki Ebihara
      Pages 195-227

    5. Accelerating Vaccine Development During the 2013–2016 West African Ebola Virus Disease Outbreak

      • Elizabeth S. Higgs, Sheri A. Dubey, Beth A. G. Coller, Jakub K. Simon, Laura Bollinger, Robert A. Sorenson et al.
      Pages 229-261

    6. Therapeutics Against Filovirus Infection

      • John Connor, Gary Kobinger, Gene Olinger
      Pages 263-290

  4. Replication: at Cellular Level and Below

    1. Front Matter

      Pages 291-291
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    2. Filovirus Strategies to Escape Antiviral Responses

      • Judith Olejnik, Adam J. Hume, Daisy W. Leung, Gaya K. Amarasinghe, Christopher F. Basler, Elke Mühlberger
      Pages 293-322

    3. Mechanisms of Filovirus Entry

      • R.A. Davey, O. Shtanko, M. Anantpadma, Y. Sakurai, K. Chandran, W. Maury
      Pages 323-352

    4. Inside the Cell: Assembly of Filoviruses

      • Larissa Kolesnikova, Asuka Nanbo, Stephan Becker, Yoshihiro Kawaoka
      Pages 353-380

    5. Filovirus Structural Biology: The Molecules in the Machine

      • Robert N. Kirchdoerfer, Hal Wasserman, Gaya K. Amarasinghe, Erica Ollmann Saphire
      Pages 381-417

  5. Tools and Taxonomy

    1. Front Matter

      Pages 419-419
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    2. Reverse Genetics of Filoviruses

      • Thomas Hoenen, Janine Brandt, Yíngyún Caì, Jens H. Kuhn, Courtney Finch
      Pages 421-445
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Keywords

About this book

This volume provides an overview of recent advances in our understanding of the biology of marburg- and ebolaviruses. It focuses on four essential areas: 1) ecology, outbreaks and clinical management, 2) disease, pathogenesis and protection, 3) virus replication inside the cell, and 4) molecular tools for virus study and taxonomy.

For 50 years, these viruses have spilled over sporadically and without warning from their wildlife reservoirs, often causing major outbreaks and high fatalities. The consequences can be devastating, with a clear potential for global reach, as demonstrated by the 2013 West African outbreak of Ebola virus, which led to over 28,000 reported cases across three continents and more than 11,000 deaths. Given the international threat posed by these viruses, the pace and scope of basic research have also greatly intensified, ranging from studies of virus emergence, epidemiology, antiviral countermeasures and human disease to detailed mechanistic studies of virus entry, replication, virion assembly and protein structure.

Written by internationally respected experts, this book will appeal to a wide audience and be a valuable resource for basic researchers, clinicians and advanced students alike.

Editors and Affiliations

  • Boston University School of Medicine , Boston, USA

    Elke Mühlberger

  • NIAID, National Institutes of Health NIAID, Frederick, USA

    Lisa L. Hensley

  • Centers for Disease Control & Prevention, Atlanta, USA

    Jonathan S. Towner

About the editors

Elke MühlbergerBoston University School of Medicine 

Boston, MA, USA
e-mail: muehlber@bu.edu


Lisa L. Hensley
National Institutes of Health
NIAID

Frederick, MD, USA

e-mail: Lisa.Hensley@nih.gov


Jonathan S. Towner
Centers for Disease Control & Prevention
Atlanta, GA, USA

e-mail: jit8@cdc.gov

Bibliographic Information

  • Book Title: Marburg- and Ebolaviruses

  • Book Subtitle: From Ecosystems to Molecules

  • Editors: Elke Mühlberger, Lisa L. Hensley, Jonathan S. Towner

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-319-68948-7

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG (outside the USA) 2017

  • Hardcover ISBN: 978-3-319-68946-3Published: 30 January 2018

  • Softcover ISBN: 978-3-319-88689-3Published: 06 June 2019

  • eBook ISBN: 978-3-319-68948-7Published: 23 December 2017

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: X, 460

  • Topics: Virology, Infectious Diseases, Epidemiology

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