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Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy

  • Book
  • © 2017

Overview

Editors:
  1. Pawel Kalinski

    1. Department of Medicine and Center for Immunotherapy, Roswell Park Cancer Institute, Buffalo, USA

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  • Sheds light on the mechanisms, factors, and mediators that are involved in the dynamic cancer cell environment
  • Volume explores the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment
  • Focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1036)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Tumor Immuno-Environment in Cancer Progression and Therapy

    • Pawel Kalinski, James E. Talmadge
    Pages 1-18

  3. Cancer Immunotherapy Targets Based on Understanding the T Cell-Inflamed Versus Non-T Cell-Inflamed Tumor Microenvironment

    • Thomas F. Gajewski, Leticia Corrales, Jason Williams, Brendan Horton, Ayelet Sivan, Stefani Spranger
    Pages 19-31

  4. Regulation of CTL Infiltration Within the Tumor Microenvironment

    • Sarah E. Church, Jérôme Galon
    Pages 33-49

  5. The Role of Tumor Microenvironment in Cancer Immunotherapy

    • Timothy Frankel, Mirna Perusina Lanfranca, Weiping Zou
    Pages 51-64

  6. Immunogenic and Non-immunogenic Cell Death in the Tumor Microenvironment

    • Jonathan M. Pitt, Guido Kroemer, Laurence Zitvogel
    Pages 65-79

  7. Exosomes in Cancer: Another Mechanism of Tumor-Induced Immune Suppression

    • Theresa L. Whiteside
    Pages 81-89

  8. Chemo-Immunotherapy: Role of Indoleamine 2,3-Dioxygenase in Defining Immunogenic Versus Tolerogenic Cell Death in the Tumor Microenvironment

    • Theodore S. Johnson, Tracy Mcgaha, David H. Munn
    Pages 91-104

  9. Targeting Myeloid-Derived Suppressor Cells in Cancer

    • Waseem Anani, Michael R. Shurin
    Pages 105-128

  10. Tryptophan Catabolism and Cancer Immunotherapy Targeting IDO Mediated Immune Suppression

    • Adaobi Amobi, Feng Qian, Amit A. Lugade, Kunle Odunsi
    Pages 129-144

  11. Lipid Inflammatory Mediators in Cancer Progression and Therapy

    • Saraswoti Khadge, John Graham Sharp, Timothy R. McGuire, Geoffrey M. Thiele, James E. Talmadge
    Pages 145-156

  12. Oncolytic Virotherapy and the Tumor Microenvironment

    • Sara E. Berkey, Steve H. Thorne, David L. Bartlett
    Pages 157-172

  13. The Impact of Housing Temperature-Induced Chronic Stress on Preclinical Mouse Tumor Models and Therapeutic Responses: An Important Role for the Nervous System

    • Bonnie L. Hylander, Jason W.-L. Eng, Elizabeth A. Repasky
    Pages 173-189

  14. Immunotherapeutic Targeting of Tumor-Associated Blood Vessels

    • Kellsye L. Fabian, Walter J. Storkus
    Pages 191-211

  15. Adaptive Resistance to Cancer Immunotherapy

    • A. J. Robert McGray, Jonathan Bramson
    Pages 213-227

  16. Imaging the Tumor Microenvironment

    • Marie-Caline Z. Abadjian, W. Barry Edwards, Carolyn J. Anderson
    Pages 229-257

  17. Back Matter

    Pages 259-264
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Keywords

About this book

The tumor microenvironment has become a very important and hot topic in cancer research within the past few years. The tumor microenvironment is defined as the normal cells, molecules, and blood vessels that surround and feed a tumor cell. As many scientists have realized, studying the tumor microenvironment has become critical to moving the field forward, since there are many players in a tumor’s localized and surrounding area, which can significantly change cancer cell behavior. There is a dual relationship wherein the tumor can change its microenvironment and the microenvironment can affect how a tumor grows and spreads. Tumor Microenvironment in Cancer Progression and Cancer Therapy aims to shed light on the mechanisms, factors, and mediators that are involved in the cancer cell environment. Recent studies have demonstrated that in addition to promoting tumor progression and protecting tumor cells from the spontaneous immune-mediated rejection and different forms of cancer therapeutics, tumor microenvironment can also be a target and mediator of both standard and newly-emerging forms of cancer therapeutics. Thus, the dual role of the tumor microenvironment is the integral focus of the volume.  The volume highlights the bi-directional interactions between tumor cells and non-malignant tumor component during tumor progression and treatment. It also focuses on the three groups of the reactive tumor component: stromal cells, blood vessels and the infiltrating immune cells. These three groups are discussed under the lens of their role in promoting tumor growth, shielding the tumor from rejection and from standard forms of cancer therapies. They are emerging as targets and mediators of standard and new forms of potential therapy.

Editors and Affiliations

  • Department of Medicine and Center for Immunotherapy, Roswell Park Cancer Institute, Buffalo, USA

    Pawel Kalinski

About the editor

Pawel Kalinski, M.D., Ph.D., is the Vice Chair for Translational Research and Professor of Oncology in the Department of Medicine at Roswell Park Cancer Institute (RPCI) in Buffalo, NY. He is also the Director of Cancer Vaccine and Dendritic Cell Therapies in the Center for Immunotherapy, and a Co-Leader of the Tumor Immunology & Immunotherapy Program of RPCI. Dr. Kalinski is a member of the Society for Immunotherapy of Cancer (SITC), American Association of Immunologists (AAI), American Association for Cancer Research (AACR) and the American Society of Clinical Investigation (ASCI) and an editorial board member of several journals in the area of cancer immunology and immunotherapy. He has been the recipient of multiple grants from the National Cancer Institute in recent years. Dr. Kalinski has published over 130 papers in the areas of immunology and cancer research and has been cited over 5,500 times.

Bibliographic Information

  • Book Title: Tumor Immune Microenvironment in Cancer Progression and Cancer Therapy

  • Editors: Pawel Kalinski

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-319-67577-0

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2017

  • Hardcover ISBN: 978-3-319-67575-6Published: 05 February 2018

  • Softcover ISBN: 978-3-319-88450-9Published: 04 June 2019

  • eBook ISBN: 978-3-319-67577-0Published: 22 December 2017

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIV, 264

  • Number of Illustrations: 4 b/w illustrations, 43 illustrations in colour

  • Topics: Cancer Research, Oncology, Immunology, Molecular Medicine

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