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IgM and Its Receptors and Binding Proteins

  • Book
  • © 2017

Overview

Editors:
  1. Hiromi Kubagawa

    1. Deutsches Rheumaforschungszentrum, Berlin, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Peter D. Burrows

    1. Department of Microbiology, University of Alabama at Birmingham, Birmingham, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Provides a state-of-the-art update on the IgM antibody and its receptors and binding proteins
  • Reviews the key research in this field
  • An invaluable reference source for scientists and physicians
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 408)

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Table of contents (5 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. The Appearance and Diversification of Receptors for IgM During Vertebrate Evolution

    • Srinivas Akula, Lars Hellman
    Pages 1-23

  3. Authentic IgM Fc Receptor (FcμR)

    • Hiromi Kubagawa, Christopher M. Skopnik, Jakob Zimmermann, Pawel Durek, Hyun-Dong Chang, Esther Yoo et al.
    Pages 25-45

  4. FCRLA—A Resident Endoplasmic Reticulum Protein that Associates with Multiple Immunoglobulin Isotypes in B Lineage Cells

    • Tessa E. Blackburn, Teresa Santiago, Peter D. Burrows
    Pages 47-65

  5. Specific IgM and Regulation of Antibody Responses

    • Anna Sörman, Birgitta Heyman
    Pages 67-87

  6. Role of Natural IgM Autoantibodies (IgM-NAA) and IgM Anti-Leukocyte Antibodies (IgM-ALA) in Regulating Inflammation

    • Peter I. Lobo
    Pages 89-117
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Keywords

About this book

This volume reviews the current state of research on the IgM antibody and its multiple receptors and binding proteins. Interactions of the IgM ligands with these molecules are important for protection against infections as a first line of defense, as well as for regulation of immune responses to pathogens and self-antigens. The book includes up-to-date information on: (i) the phylogeny of three IgM-binding receptors [polymeric Ig receptor (pIgR), Fc receptor for both IgA and IgM (Fcα/µR), and Fc receptor for IgM only (FcµR)]; (ii) the lymphocyte-restricted distribution and unique ligand-binding activity of FcµR; (iii) the definition and potential function of Fc receptor-like molecule A (FCRLA) as a resident endoplasmic reticulum protein that binds IgM, but also IgG and IgA; (iv) IgM antibody-mediated enhancement of humoral immune responses, highlighting the importance of complement and its receptors, (v) the numerous important roles of IgM natural antibodies in regulation of inflammation. It is an invaluable resource for researchers and clinicians alike.

Editors and Affiliations

  • Deutsches Rheumaforschungszentrum, Berlin, Germany

    Hiromi Kubagawa

  • Department of Microbiology, University of Alabama at Birmingham, Birmingham, USA

    Peter D. Burrows

About the editors

Hiromi Kubagawa, MD, is presently Guest Senior Scientist at Deutsches Rheuma-Forschungszentrum, Berlin, Germany 
Peter D. Burrows, PhD,  is a professor at Dept. of Microbiology, University of Alabama at Birmingham, AL, USA

Bibliographic Information

  • Book Title: IgM and Its Receptors and Binding Proteins

  • Editors: Hiromi Kubagawa, Peter D. Burrows

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-319-64526-1

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2017

  • Hardcover ISBN: 978-3-319-64524-7Published: 03 November 2017

  • Softcover ISBN: 978-3-319-87810-2Published: 18 May 2018

  • eBook ISBN: 978-3-319-64526-1Published: 24 October 2017

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: IX, 117

  • Number of Illustrations: 15 b/w illustrations, 15 illustrations in colour

  • Topics: Immunology, Infectious Diseases, Rheumatology

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