Overview
- Describes modern and conventional syntheses of acridine scaffolds
- Presents structural aspects of interactions with proteins which provide useful tips for designing enzyme inhibitors involved in the treatment of neurodegenerative diseases
- Discusses structural aspects of interactions with nucleic acids, which helps readers to design a specific binder for the targeting of quadruplexes involved in cancer
- Includes supplementary material: sn.pub/extras
Part of the book series: Progress in Drug Research (PDR, volume 72)
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Table of contents (12 chapters)
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Front Matter
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Back Matter
Keywords
About this book
This book describes applications of acridines for the treatment of various neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, and various prion diseases, and discusses the potential of acridines in neuro-regenerative medicine. Using modern data-mining software, it presents structures of acridines with nucleic acids and proteins and compares them with the native structures. Furthermore, the book presents modern methods of acridine synthesis, comparing them with the most useful conventional methods. Acridines interact with both nucleic acids and proteins, and due to their direct interactions with various enzymes, they can be suitable for the treatment of neurodegenerative diseases, inflammation, immunological disorders, and protozoal diseases. The characteristic spectral properties of acridines can be employed in labeling proteins, nucleic acids, lipids, and even cells and their compartments. Moreover, they can be applied in photodynamic therapy.
Authors and Affiliations
About the authors
Bibliographic Information
Book Title: Biomedical Applications of Acridines
Book Subtitle: Derivatives, Syntheses, Properties and Biological Activities with a Focus on Neurodegenerative Diseases
Authors: Jan Ježek, Jan Hlaváček, Jaroslav Šebestík
Series Title: Progress in Drug Research
DOI: https://doi.org/10.1007/978-3-319-63953-6
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing AG, part of Springer Nature 2017
Hardcover ISBN: 978-3-319-63952-9Published: 24 August 2017
Softcover ISBN: 978-3-319-87680-1Published: 11 August 2018
eBook ISBN: 978-3-319-63953-6Published: 15 August 2017
Series ISSN: 0071-786X
Series E-ISSN: 2297-4555
Edition Number: 1
Number of Pages: XIII, 237
Number of Illustrations: 54 b/w illustrations, 25 illustrations in colour
Topics: Medicinal Chemistry, Neurochemistry, Pharmacology/Toxicology, Protein-Ligand Interactions, Bioorganic Chemistry, Nucleic Acid Chemistry