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Precision Medicine, CRISPR, and Genome Engineering

Moving from Association to Biology and Therapeutics

  • Book
  • © 2017

Overview

Editors:
  1. Stephen H. Tsang

    1. Departments of Ophthalmology, Pathology & Cell Biology and Biomedical Engineering, Institute of Human Nutrition, Columbia Stem Cell Initiative, Herbert Irving Comprehensive Cancer Center, Graduate Program in Neurobiology & Behavior, Columbia University, New York, USA

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  • Timely State-of-the-science on CRISPR and gene editing, an exciting and controversial frontier in regenerative medicine
  • Contributed by top experts in this rapidly-evolving field
  • One of the first books to connect genetically modified foods to this area
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1016)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. Introduction to the CRISPR Revolution

    1. Front Matter

      Pages 1-1
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    2. Viral Vectors, Engineered Cells and the CRISPR Revolution

      • James E. DiCarlo, Anurag Deeconda, Stephen H. Tsang
      Pages 3-27

    3. Combining Engineered Nucleases with Adeno-associated Viral Vectors for Therapeutic Gene Editing

      • Benjamin E. Epstein, David V. Schaffer
      Pages 29-42

  3. CRISPR in Model Systems

    1. Front Matter

      Pages 43-43
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    2. From Reductionism to Holism: Toward a More Complete View of Development Through Genome Engineering

      • Rebecca K. Delker, Richard S. Mann
      Pages 45-74

    3. A Transgenic Core Facility’s Experience in Genome Editing Revolution

      • Celvie L. Yuan, Yueh-Chiang Hu
      Pages 75-90

    4. Genome Editing to Study Ca2+ Homeostasis in Zebrafish Cone Photoreceptors

      • Susan E. Brockerhoff
      Pages 91-100

    5. CRISPR: From Prokaryotic Immune Systems to Plant Genome Editing Tools

      • Anindya Bandyopadhyay, Shamik Mazumdar, Xiaojia Yin, William Paul Quick
      Pages 101-120

  4. The Future of CRISPR

    1. Front Matter

      Pages 121-121
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    2. Target Discovery for Precision Medicine Using High-Throughput Genome Engineering

      • Xinyi Guo, Poonam Chitale, Neville E. Sanjana
      Pages 123-145

    3. CRISPR in the Retina: Evaluation of Future Potential

      • Galaxy Y. Cho, Sally Justus, Jesse D. Sengillo, Stephen H. Tsang
      Pages 147-155

    4. The Future of CRISPR Applications in the Lab, the Clinic and Society

      • Soren H. Hough, Ayokunmi Ajetunmobi
      Pages 157-178
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Keywords

About this book

This book presents descriptive overviews of gene editing strategies across multiple species while also offering in-depth insight on complex cases of application in the field of tissue engineering and regenerative medicine.  Chapters feature contributions from leaders in stem cell therapy and biology, providing a comprehensive view of the application of gene therapy in numerous fields with an emphasis on ophthalmology, stem cells, and agriculture. The book also highlights recent major technological advances, including ZFN, TALEN, and CRISPR. Precision Medicine, CRISPR, and Genome Engineering is part of the highly successful Advances in Experimental Medicine and Biology series. It is an indispensable resource for researchers and students in genetics as well as clinicians. 

Editors and Affiliations

  • Departments of Ophthalmology, Pathology & Cell Biology and Biomedical Engineering, Institute of Human Nutrition, Columbia Stem Cell Initiative, Herbert Irving Comprehensive Cancer Center, Graduate Program in Neurobiology & Behavior, Columbia University, New York, USA

    Stephen H. Tsang

About the editor

For years, Stephen Tsang has been culturing embryonic stem (ES) cells and created the first mouse model for a recessive form of retinitis pigmentosa by applying homologous recombination to ES cell technology. Two elements define his laboratory. First, by leveraging his genetics clinical practice, in which over 1000 retinal patients are cared for, he brings an array of clinical resources to his research, including stem cells and live imaging data. Second, he and his students are recognized authorities in a broad array of state-of-the-art technologies. Most recently, he was invited as a Moderator for the Gene Editing/Rewriting the Genome session during the 65th American Society of Human Genetics Annual Meeting.

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