Pulmonary Vasculature Redox Signaling in Health and Disease

1. Front Matter

   Pages i-xxi

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2. Adventitial Fibroblast Nox4 Expression and ROS Signaling in Pulmonary Arterial Hypertension

   • Scott A. Barman, David Fulton

   Pages 1-11

3. Role of Transcription Factors in Pulmonary Artery Smooth Muscle Cells: An Important Link to Hypoxic Pulmonary Hypertension

   • Annarita Di Mise, Yong-Xiao Wang, Yun-Min Zheng

   Pages 13-32

4. Molecular Basis of Nitrative Stress in the Pathogenesis of Pulmonary Hypertension

   • Colin E. Evans, You-Yang Zhao

   Pages 33-45

5. Pentose Shunt, Glucose-6-Phosphate Dehydrogenase, NADPH Redox, and Stem Cells in Pulmonary Hypertension

   • Ryota Hashimoto, Sachin Gupte

   Pages 47-55

6. Redox Regulation of the Superoxide Dismutases SOD3 and SOD2 in the Pulmonary Circulation

   • Daniel Hernandez-Saavedra, Kalin Swain, Rubin Tuder, Steen V. Petersen, Eva Nozik-Grayck

   Pages 57-70

7. A Brief Overview of Nitric Oxide and Reactive Oxygen Species Signaling in Hypoxia-Induced Pulmonary Hypertension

   • Ariel Jaitovich, David Jourd’heuil

   Pages 71-81

8. Altered Redox Balance in the Development of Chronic Hypoxia-induced Pulmonary Hypertension

   • Nikki L. Jernigan, Thomas C. Resta, Laura V. Gonzalez Bosc

   Pages 83-103

9. ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS)

   • Manuela Kellner, Satish Noonepalle, Qing Lu, Anup Srivastava, Evgeny Zemskov, Stephen M. Black

   Pages 105-137

10. Redox-Dependent Calpain Signaling in Airway and Pulmonary Vascular Remodeling in COPD

    • Laszlo Kovacs, Yunchao Su

    Pages 139-160

11. Natural Antioxidants as Potential Therapy, and a Promising Role for Melatonin Against Pulmonary Hypertension

    • Gerald J. Maarman

    Pages 161-178

12. Effects of Hyperoxia on the Developing Airway and Pulmonary Vasculature

    • Christina M. Pabelick, Michael A. Thompson, Rodney D. Britt Jr

    Pages 179-194

13. Lung Ischaemia–Reperfusion Injury: The Role of Reactive Oxygen Species

    • Oleg Pak, Akylbek Sydykov, Djuro Kosanovic, Ralph T. Schermuly, Alexander Dietrich, Katrin Schröder et al.

    Pages 195-225

14. Redox Mechanisms Influencing cGMP Signaling in Pulmonary Vascular Physiology and Pathophysiology

    • Dhara Patel, Anand Lakhkar, Michael S. Wolin

    Pages 227-240

15. Metabolic Reprogramming and Redox Signaling in Pulmonary Hypertension

    • Lydie Plecitá-Hlavatá, Angelo D’alessandro, Karim El Kasmi, Min Li, Hui Zhang, Petr Ježek et al.

    Pages 241-260

16. Hydrogen Sulfide as an O2 Sensor: A Critical Analysis

    • Jesus Prieto-Lloret, Philip I. Aaronson

    Pages 261-276

17. Redox Signaling and Persistent Pulmonary Hypertension of the Newborn

    • Megha Sharma, Adeleye J. Afolayan

    Pages 277-287

18. Cross Talk Between Mitochondrial Reactive Oxygen Species and Sarcoplasmic Reticulum Calcium in Pulmonary Arterial Smooth Muscle Cells

    • Tengyao Song, Yun-Min Zheng, Yong-Xiao Wang

    Pages 289-298

19. Endothelial Cell Reactive Oxygen Species and Ca2+ Signaling in Pulmonary Hypertension

    • Karthik Suresh, Larissa A. Shimoda

    Pages 299-314

20. Redox Signaling in the Right Ventricle

    • Yuichiro J. Suzuki, Nataliia V. Shults

    Pages 315-323

The main goal of this book is to form a high-quality platform in which well-known and emerging pioneering basic, translational and clinical scientists can present their latest, exciting findings in the studies of redox signaling in the pulmonary vasculature. Content from outstanding investigators with unique expertise and skills of molecular and cell biology, biochemistry, physiology, pharmacology, biophysics, biotechnology and medicine will update our current out-of-date concepts with new knowledge. Rapidly increasing scientific studies have gathered a large volume of novel and important information on redox signaling in healthy and diseased pulmonary vasculature. This volume covers the need for a cohesive book to display state-of-the-art advances in the field.   

The second major aim of this book is to help direct future research. Redox signaling is a major molecular process involved in almost every physiologic cellular response in the pulmonary vasculature including energy metabolism, host defense, gene expression, contraction, proliferation, and migration. Aberrancy in this important signaling pathway leads to a critical role in the development of nearly all pulmonary diseases, such as pulmonary hypertension, cor pulmonale, pulmonary edema, and vasculitis, among others.  

• reactive oxygen species
• ROS
• pulmonary hypertension
• redox molecules
• cellular response
• antioxidant enzymes

• Department of Molecular and Cellular Physiology, Albany Medical College, Albany, USA

  Yong-Xiao Wang

Dr. Yong-Xiao Wang is a Full Professor in the Department of Molecular and Cellular Physiology at Albany Medical College, Albany, New York, USA. He received his M.D. at the Wannan Medical College (China), Ph.D. at the Fourth Military Medical University (China), and postdoctoral training at the Technical University of Munich (Germany) as well as the University of Pennsylvania (USA). Dr. Wang’s primary research interests have focused on basic, translational, and drug discovery research concerning cardiac arrhythmias and hypertrophy, pulmonary hypertension, asthma, and diabetes for over 30 years. In particular, he has had extensive research experience in the studies of the molecular geneses, regulatory mechanisms, network pathways, physiological functions, and the critical roles of calcium, redox, inflammatory, and other signaling in the aforementioned illnesses. Dr. Wang has been the corresponding author, first author, and key contributor in numerous publications in highly peer-reviewed journals including Antioxid Redox Signal, Proc Natl Acad Sci USA, Free Radic Biol Med, Cell Calcium, J Gen Physiol, J Biol Chem, FASEB J, Nature, Circ Res, and more. He has been the editor of several academic books in the field including a recent one entitled “Calcium Signaling in Airway Smooth Muscle Cells” that was published by Springer in 2014. Dr. Wang has been the principal investigator on multiple research grants and awards from the National Institutes of Health, American Heart Association, American Diabetes Association, and other agencies. He has collaborated with numerous well-known scientists, served on various grant review panels, been the Editor-In-Chief and Editorial Board Member for several scientific journals, and trained a number of scholars, some of whom have become well-known independent investigators in the field.

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