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Viruses, Genes, and Cancer

  • Book
  • © 2017

Overview

Editors:
  1. Eric Hunter

    1. Emory Vaccine Center, Emory University, Atlanta, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Klaus Bister

    1. Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innsbruck, Austria

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    You can also search for this editor in PubMed   Google Scholar

  • Includes a foreword by the Nobel laureates J. Michael Bishop and Harold Varmus
  • Casts new light on the role of viruses and genes in the etiology of human cancer
  • Discusses the latest developments in HIV vaccine development
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 407)

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Exchange of Genetic Sequences Between Viruses and Hosts

    • Robin A. Weiss
    Pages 1-29

  3. Virus-Host Gene Interactions Define HIV-1 Disease Progression

    • Daniela C. Monaco, Zachary Ende, Eric Hunter
    Pages 31-63

  4. Sequencing the Biology of Entry: The Retroviral env Gene

    • Ronald Swanstrom, William D. Graham, Shuntai Zhou
    Pages 65-82

  5. Infectious Agents in Bovine Red Meat and Milk and Their Potential Role in Cancer and Other Chronic Diseases

    • Harald zur Hausen, Timo Bund, Ethel-Michele de Villiers
    Pages 83-116

  6. MYC and RAF: Key Effectors in Cellular Signaling and Major Drivers in Human Cancer

    • Eduard Stefan, Klaus Bister
    Pages 117-151

  7. Oncogenic Roles of the PI3K/AKT/mTOR Axis

    • Masahiro Aoki, Teruaki Fujishita
    Pages 153-189

  8. MicroRNA Dysregulation to Identify Novel Therapeutic Targets

    • Carlo M. Croce
    Pages 191-203

  9. The Evolution of Tumor Formation in Humans and Mice with Inherited Mutations in the p53 Gene

    • Arnold J Levine
    Pages 205-221
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Keywords

About this book

This volume focuses on virus-host cell interactions, cellular genes acquired or modulated by viruses, the pathological effects of these interactions, and therapeutic interventions. Several chapters specifically address the role of viruses and genes – such as oncogenes, proto-oncogenes, or tumor suppressor genes – in the etiology of human cancer. Oncogenic signaling by PI3 kinase, mTOR, Akt, or the major cancer drivers MYC and RAF, and the role of tumor suppressors like p53, are discussed in detail. The volume also explores the emerging role of noncoding RNAs such as microRNAs in tumorigenesis and cancer therapeutics, and offers new insights into the role of HIV-host interactions relevant to pathogenesis and treatment. Gathering contributions written by leading scientists in their respective fields, the volume offers a valuable resource for researchers and clinicians alike.

Editors and Affiliations

  • Emory Vaccine Center, Emory University, Atlanta, USA

    Eric Hunter

  • Institute of Biochemistry and Center for Molecular Biosciences, University of Innsbruck, Innsbruck, Austria

    Klaus Bister

About the editors

Eric Hunter, PhD, is a Professor of Pathology and Laboratory Medicine and a Georgia Research Alliance Eminent Scholar, based in Atlanta, GA, USA

Klaus Bister, PhD, is a Professor Emeritus of Biochemistry of University of Innsbruck, Austria, and a Professor Adjunct of The Scripps Research Institute, La Jolla, CA, USA  

Bibliographic Information

  • Book Title: Viruses, Genes, and Cancer

  • Editors: Eric Hunter, Klaus Bister

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-319-61804-3

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2017

  • Hardcover ISBN: 978-3-319-61803-6Published: 06 September 2017

  • Softcover ISBN: 978-3-319-87167-7Published: 11 August 2018

  • eBook ISBN: 978-3-319-61804-3Published: 25 August 2017

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: XIII, 221

  • Topics: Cancer Research, Virology

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