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Personalised Medicine

Lessons from Neurodegeneration to Cancer

  • Book
  • © 2017

Overview

Editors:
  1. Sherif El-Khamisy

    1. Krebs Institute and Sheffield Institute for Nucleic Acids, Department of Molecular Biology and Biotechnology, Firth Court, University of Sheffield, Sheffield, United Kingdom

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  • Includes tips on how to apply genome differences in personalized medicine
  • Provides a road map for studying cancer and degenerative disease: two sides of the same coin
  • Each chapter includes 10 takeaway messages to help the reader to learn quickly

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1007)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-viii
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  2. Approaches for Identifying Novel Targets in Precision Medicine: Lessons from DNA Repair

    • Dean T. Williams, Christopher J. Staples
    Pages 1-16

  3. Nucleotide Excision Repair: From Neurodegeneration to Cancer

    • Anastasios Liakos, Matthieu D. Lavigne, Maria Fousteri
    Pages 17-39

  4. Role of Protein Linked DNA Breaks in Cancer

    • Walaa R. Allam, Mohamed E. Ashour, Amr A. Waly, Sherif El-Khamisy
    Pages 41-58

  5. The Emerging Role of Proteomics in Precision Medicine: Applications in Neurodegenerative Diseases and Neurotrauma

    • Rana Alaaeddine, Mira Fayad, Eliana Nehme, Hisham F. Bahmad, Firas Kobeissy
    Pages 59-70

  6. The Role of Nitric Oxide from Neurological Disease to Cancer

    • Ahmed Maher, Mohamed F. Abdel Rahman, Mohamed Z. Gad
    Pages 71-88

  7. RNA Nuclear Export: From Neurological Disorders to Cancer

    • Guillaume M. Hautbergue
    Pages 89-109

  8. Can Astrocytes Be a Target for Precision Medicine?

    • Chloe F. Allen, Pamela J. Shaw, Laura Ferraiuolo
    Pages 111-128

  9. Mitochondrial Diseases as Model of Neurodegeneration

    • Laila A. Selim, Heba Hassaan
    Pages 129-155

  10. Personalised Medicine: Genome Maintenance Lessons Learned from Studies in Yeast as a Model Organism

    • Arwa A. Abugable, Dahlia A. Awwad, Dalia Fleifel, Mohamed M. Ali, Sherif El-Khamisy, Menattallah Elserafy
    Pages 157-178

  11. The Power of Zebrafish in Personalised Medicine

    • Sarah Baxendale, Freek van Eeden, Robert Wilkinson
    Pages 179-197

  12. Personalized Medicine and Resurrected Hopes for the Management of Alzheimer’s Disease: A Modular Approach Based on GSK-3β Inhibitors

    • Reem K. Arafa, Nehal H. Elghazawy
    Pages 199-224

  13. Regenerative Medicine: Advances from Developmental to Degenerative Diseases

    • Nicholas F. Blair, Thomas J. R. Frith, Ivana Barbaric
    Pages 225-239

  14. Gene Therapy in the Nervous System: Failures and Successes

    • Jayanth S. Chandran, Joseph M. Scarrott, Pamela J. Shaw, Mimoun Azzouz
    Pages 241-257

  15. Back Matter

    Pages 259-260
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Keywords

About this book

The mammalian genome is constantly challenged by exogenous and endogenous threats. Although much is known about the mechanisms that maintain genome integrity, little is known about the applications of this knowledge to combat human disease. The past 20 years has witnessed extensive research and progress in this area and scientists started to design new therapies harnessing individual genetic differences among patients to combat degenerative disorders and cancer. We summarize these advancements and discuss perspectives for the future of personalized medicine.

Editors and Affiliations

  • Krebs Institute and Sheffield Institute for Nucleic Acids, Department of Molecular Biology and Biotechnology, Firth Court, University of Sheffield, Sheffield, United Kingdom

    Sherif El-Khamisy

Bibliographic Information

  • Book Title: Personalised Medicine

  • Book Subtitle: Lessons from Neurodegeneration to Cancer

  • Editors: Sherif El-Khamisy

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-319-60733-7

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2017

  • Hardcover ISBN: 978-3-319-60731-3Published: 11 September 2017

  • Softcover ISBN: 978-3-319-86922-3Published: 18 August 2018

  • eBook ISBN: 978-3-319-60733-7Published: 24 August 2017

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VIII, 260

  • Number of Illustrations: 46 b/w illustrations, 52 illustrations in colour

  • Topics: Cancer Research, Gene Function, Molecular Medicine

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