Neurotoxicity of Metals

1. Front Matter

   Pages i-vi

   PDF

2. Developmental Neurotoxicity

   1. Front Matter

      Pages 1-1

      PDF

   2. Developmental Neurotoxicity of Lead

      • Samuel Caito, Michael Aschner

      Pages 3-12

   3. Manganese and Developmental Neurotoxicity

      • Roberto Lucchini, Donatella Placidi, Giuseppa Cagna, Chiara Fedrighi, Manuela Oppini, Marco Peli et al.

      Pages 13-34

   4. Inherited Disorders of Manganese Metabolism

      • Charles E. Zogzas, Somshuvra Mukhopadhyay

      Pages 35-49

3. Neurodegenerative Disorders

   1. Front Matter

      Pages 51-51

      PDF

   2. Chemical Speciation of Selenium and Mercury as Determinant of Their Neurotoxicity

      • C. S. Oliveira, B. C. Piccoli, M. Aschner, J. B. T. Rocha

      Pages 53-83

   3. Metals and Paraoxonases

      • Lucio G. Costa, Toby B. Cole, Jacqueline M. Garrick, Judit Marsillach, Clement E. Furlong

      Pages 85-111

   4. Manganese and the Insulin-IGF Signaling Network in Huntington’s Disease and Other Neurodegenerative Disorders

      • Miles R. Bryan, Aaron B. Bowman

      Pages 113-142

   5. Occupational Metal Exposure and Parkinsonism

      • W. Michael Caudle

      Pages 143-158

   6. Inflammatory Activation of Microglia and Astrocytes in Manganese Neurotoxicity

      • Ronald B. Tjalkens, Katriana A. Popichak, Kelly A. Kirkley

      Pages 159-181

   7. Aluminum and Alzheimer’s Disease

      • Maria Teresa Colomina, Fiona Peris-Sampedro

      Pages 183-197

   8. Copper and Alzheimer’s Disease

      • Zoe K. Mathys, Anthony R. White

      Pages 199-216

   9. Uranium and the Central Nervous System: What Should We Learn from Recent New Tools and Findings?

      • Céline Dinocourt

      Pages 217-225

   10. Neurotoxicity of Metal Mixtures

       • V. M. Andrade, M. Aschner, A. P. Marreilha dos Santos

       Pages 227-265

   11. Methylmercury-Induced Neurotoxicity: Focus on Pro-oxidative Events and Related Consequences

       • Marcelo Farina, Michael Aschner

       Pages 267-286

   12. Neurotoxicity of Vanadium

       • Hilary Afeseh Ngwa, Muhammet Ay, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy

       Pages 287-301

   13. Neurotoxicity of Zinc

       • Deborah R. Morris, Cathy W. Levenson

       Pages 303-312

   14. Neurotoxicity of Copper

       • Felix Bulcke, Ralf Dringen, Ivo Florin Scheiber

       Pages 313-343

   15. Thallium Toxicity: General Issues, Neurological Symptoms, and Neurotoxic Mechanisms

       • Laura Osorio-Rico, Abel Santamaria, Sonia Galván-Arzate

       Pages 345-353

Assembles international authorities to address contemporary research in metal neurotoxicity. Essential and non-essential metals play an important role in neurodevelopmental and neurodegenerative diseases. Recent developments in understanding the role of metals in the etiology of these disorders have led to rapid growth in clarifying the pathology of some of the most devastating diseases we face and in identifying potential new therapies. Few books or periodicals have been wholly dedicated to the topic of metals, and this collection is intended to serve as a resource for all researchers interested in metals and their role in health and disease.

• neurotoxicity
• metals
• neurodegenerative disease
• neurodevelopmental disease
• pathology

• Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, USA

  Michael Aschner

• Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, USA

  Lucio G. Costa

Michael Aschner is the Gray E. B. Stahlman Professor of Pediatrics and Pharmacology at Vanderbilt University School of Medicine as well as a Senior Investigator at the Kennedy Center for Research on Human Development. Dr Aschner’s research group has a particular interest in the neurobiology and physiology of astrocytes and the signaling mechanisms associated with central nervous system injury. Dr Aschner’s laboratory studies metal uptake and distribution in the brain, investigating the mechanisms of transport of methylmercury and manganese across the capillaries of the blood–brain barrier. His research utilizes various experimental models (C. elegans, tissue cultures and rodents) to understand the acute toxicity of manganese deposition in the brains of human neonates.​Lucio G. Costa is Professor of Environmental and Occupational Health Sciences at the School of Public Health at the University of Washington. Dr. Costa is a renowned neurotoxicologist whose research interests are focused on understanding the role of neurotoxic substances in neurodevelopmental disorders and other neurological, neuropsychiatric and neurodegenerative diseases. Dr Costa’s research laboratory makes use of a variety of in vivo and in vitro cell culture systems, transgenic animal models and imaging techniques to study the cellular, biochemical and molecular mechanisms of neurotoxicity.

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