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Neurotoxicity of Metals

  • Book
  • © 2017

Overview

Editors:
  1. Michael Aschner

    1. Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Lucio G. Costa

    1. Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Comprehensive overview of metal neurotoxicity
  • Contributions from international authorities on the subject
  • Discusses a wide range of essential and non-essential metals
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Neurobiology (NEUROBIOL, volume 18)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-vi
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  2. Developmental Neurotoxicity

    1. Front Matter

      Pages 1-1
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    2. Developmental Neurotoxicity of Lead

      • Samuel Caito, Michael Aschner
      Pages 3-12

    3. Manganese and Developmental Neurotoxicity

      • Roberto Lucchini, Donatella Placidi, Giuseppa Cagna, Chiara Fedrighi, Manuela Oppini, Marco Peli et al.
      Pages 13-34

    4. Inherited Disorders of Manganese Metabolism

      • Charles E. Zogzas, Somshuvra Mukhopadhyay
      Pages 35-49

  3. Neurodegenerative Disorders

    1. Front Matter

      Pages 51-51
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    2. Chemical Speciation of Selenium and Mercury as Determinant of Their Neurotoxicity

      • C. S. Oliveira, B. C. Piccoli, M. Aschner, J. B. T. Rocha
      Pages 53-83

    3. Metals and Paraoxonases

      • Lucio G. Costa, Toby B. Cole, Jacqueline M. Garrick, Judit Marsillach, Clement E. Furlong
      Pages 85-111

    4. Manganese and the Insulin-IGF Signaling Network in Huntington’s Disease and Other Neurodegenerative Disorders

      • Miles R. Bryan, Aaron B. Bowman
      Pages 113-142

    5. Occupational Metal Exposure and Parkinsonism

      • W. Michael Caudle
      Pages 143-158

    6. Inflammatory Activation of Microglia and Astrocytes in Manganese Neurotoxicity

      • Ronald B. Tjalkens, Katriana A. Popichak, Kelly A. Kirkley
      Pages 159-181

    7. Aluminum and Alzheimer’s Disease

      • Maria Teresa Colomina, Fiona Peris-Sampedro
      Pages 183-197

    8. Copper and Alzheimer’s Disease

      • Zoe K. Mathys, Anthony R. White
      Pages 199-216

    9. Uranium and the Central Nervous System: What Should We Learn from Recent New Tools and Findings?

      • Céline Dinocourt
      Pages 217-225

    10. Neurotoxicity of Metal Mixtures

      • V. M. Andrade, M. Aschner, A. P. Marreilha dos Santos
      Pages 227-265

    11. Methylmercury-Induced Neurotoxicity: Focus on Pro-oxidative Events and Related Consequences

      • Marcelo Farina, Michael Aschner
      Pages 267-286

    12. Neurotoxicity of Vanadium

      • Hilary Afeseh Ngwa, Muhammet Ay, Huajun Jin, Vellareddy Anantharam, Arthi Kanthasamy, Anumantha G. Kanthasamy
      Pages 287-301

    13. Neurotoxicity of Zinc

      • Deborah R. Morris, Cathy W. Levenson
      Pages 303-312

    14. Neurotoxicity of Copper

      • Felix Bulcke, Ralf Dringen, Ivo Florin Scheiber
      Pages 313-343

    15. Thallium Toxicity: General Issues, Neurological Symptoms, and Neurotoxic Mechanisms

      • Laura Osorio-Rico, Abel Santamaria, Sonia Galván-Arzate
      Pages 345-353
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Keywords

About this book

Assembles international authorities to address contemporary research in metal neurotoxicity. Essential and non-essential metals play an important role in neurodevelopmental and neurodegenerative diseases. Recent developments in understanding the role of metals in the etiology of these disorders have led to rapid growth in clarifying the pathology of some of the most devastating diseases we face and in identifying potential new therapies. Few books or periodicals have been wholly dedicated to the topic of metals, and this collection is intended to serve as a resource for all researchers interested in metals and their role in health and disease.

Editors and Affiliations

  • Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, USA

    Michael Aschner

  • Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, USA

    Lucio G. Costa

About the editors

Michael Aschner is the Gray E. B. Stahlman Professor of Pediatrics and Pharmacology at Vanderbilt University School of Medicine as well as a Senior Investigator at the Kennedy Center for Research on Human Development. Dr Aschner’s research group has a particular interest in the neurobiology and physiology of astrocytes and the signaling mechanisms associated with central nervous system injury. Dr Aschner’s laboratory studies metal uptake and distribution in the brain, investigating the mechanisms of transport of methylmercury and manganese across the capillaries of the blood–brain barrier. His research utilizes various experimental models (C. elegans, tissue cultures and rodents) to understand the acute toxicity of manganese deposition in the brains of human neonates.​Lucio G. Costa is Professor of Environmental and Occupational Health Sciences at the School of Public Health at the University of Washington. Dr. Costa is a renowned neurotoxicologist whose research interests are focused on understanding the role of neurotoxic substances in neurodevelopmental disorders and other neurological, neuropsychiatric and neurodegenerative diseases. Dr Costa’s research laboratory makes use of a variety of in vivo and in vitro cell culture systems, transgenic animal models and imaging techniques to study the cellular, biochemical and molecular mechanisms of neurotoxicity.




Bibliographic Information

  • Book Title: Neurotoxicity of Metals

  • Editors: Michael Aschner, Lucio G. Costa

  • Series Title: Advances in Neurobiology

  • DOI: https://doi.org/10.1007/978-3-319-60189-2

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG 2017

  • Hardcover ISBN: 978-3-319-60188-5Published: 18 September 2017

  • Softcover ISBN: 978-3-319-86800-4Published: 18 August 2018

  • eBook ISBN: 978-3-319-60189-2Published: 09 September 2017

  • Series ISSN: 2190-5215

  • Series E-ISSN: 2190-5223

  • Edition Number: 1

  • Number of Pages: VI, 383

  • Number of Illustrations: 19 b/w illustrations, 14 illustrations in colour

  • Topics: Neurochemistry

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