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Histiocytic Disorders

  • Book
  • © 2018

Overview

Editors:
  1. Oussama Abla

    1. University of Toronto, The Hospital for Sick Children, Toronto, Canada

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    You can also search for this editor in PubMed   Google Scholar

  2. Gritta Janka

    1. Pediatric Hematology and Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • First comprehensive book on histiocytic disorders in over ten years

  • Features the most recent advances and treatment strategies for common and uncommon histiocytic disorders

  • Written by international experts in the field

  • Includes supplementary material: sn.pub/extras

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xii
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  2. Pathology of Histiocytic Disorders

    1. Front Matter

      Pages 1-1
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    2. Pathology of Histiocytic Disorders and Neoplasms and Related Disorders

      • Jennifer Picarsic, Ronald Jaffe
      Pages 3-50

  3. Langerhans Cell Histiocytosis (LCH)

    1. Front Matter

      Pages 51-51
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    2. Biology and Genomics of LCH and Related Disorders

      • Barrett J. Rollins
      Pages 53-71

    3. Epidemiology and Clinical Manifestations of Langerhans Cell Histiocytosis in Children

      • Etai Adam, Rima Jubran, Sheila Weitzman
      Pages 73-85

    4. Central Nervous System Langerhans Cell Histiocytosis

      • Milen Minkov, Jennifer Picarsic, Karoly Lakatos
      Pages 87-101

    5. First-Line Treatment of Pediatric Langerhans Cell Histiocytosis

      • Carlos Rodriguez-Galindo, Cor van den Bos
      Pages 103-118

    6. Treatment of Relapsed and Refractory Langerhans Cell Histiocytosis in Children

      • Oussama Abla, Carlos Rodriguez-Galindo, Paul Veys
      Pages 119-137

    7. Adult Langerhans Cell Histiocytosis

      • Michael Girschikofsky, Abdellatif Tazi
      Pages 139-153

    8. Late Effects of Langerhans Cell Histiocytosis and the Association of LCH with Malignancy

      • Vasanta Nanduri, Lilibeth R. Torno, Riccardo Haupt
      Pages 155-170

  4. Hemophagocytic Lymphohistiocytosis (HLH)

    1. Front Matter

      Pages 171-171
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    2. Classification, Clinical Manifestations, and Diagnostics of HLH

      • J. Pachlopnik Schmid, Benjamin Volkmer, Stephan Ehl
      Pages 173-187

    3. CNS Involvement in HLH (CNS-HLH)

      • AnnaCarin Horne, Karin Beutel
      Pages 189-196

    4. Genetics and Pathogenesis of Hemophagocytic Lymphohistiocytosis

      • Geneviève de Saint Basile, Despina Moshous, Alain Fischer
      Pages 197-214

    5. Hemophagocytic Lymphohistiocytosis Associated with Malignancies and with Epstein-Barr Virus

      • Kai Lehmberg, Fumihiro Ochi, Kim E. Nichols, Eiichi Ishii
      Pages 215-231

    6. Macrophage Activation Syndrome in Rheumatic Diseases (MAS-HLH)

      • Alexei A. Grom, AnnaCarin Horne, Fabrizio De Benedetti
      Pages 233-246

    7. Treatment of Newly Diagnosed HLH and Refractory Disease

      • Jan-Inge Henter, Rebecca A Marsh, Tatiana von Bahr Greenwood
      Pages 247-263

    8. Hematopoietic Cell Transplantation and Novel Therapies in Hemophagocytic Lymphohistiocytosis

      • K. Scott Baker, Michael B. Jordan
      Pages 265-274

    9. HLH in Adults

      • Paul La Rosée, Rafal Machowicz
      Pages 275-290
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Keywords

About this book

This volume provides a comprehensive and world-class review of the field of histiocytic neoplasms and hemophagocytic lymphohistiocytosis (HLH). It reviews all the advances in the field of histiocytoses during the last ten years, particularly with regards to the genomic findings in LCH and other histiocytic neoplasms and the new suggested classification of the histiocytic disorders. Additionally, it features a state-of-the art update on the most recent treatment strategies for LCH, including the results of the last LCH-III international trial, salvage therapies such as reduced-intensity conditioning (RIC) stem cell transplant (SCT), and targeted therapies with BRAF and MEK inhibitors, as well as the challenging cases of CNS-neurodegenerative LCH and its therapeutic perspectives. For primary and secondary HLH the book updates the most recent genetic and pathophysiological findings, including macrophage-activation syndrome (MAS), and includes a special chapter on HLH in adults. Treatment chapters encompass therapy for newly diagnosed HLH and refractory disease as well as stem-cell transplantation and novel therapies. The text also highlights the most recent advances in the treatment of the uncommon histiocytic disorders, such as Erdheim-Chester disease (ECD), Juvenile xanthogranuloma (JXG) and JXG-like conditions, Rosai-Dorfman disease (RDD), and the very rare malignant histiocytoses.


Written by international experts in the field, Histiocytic Disorders is a valuable resource for clinicians, researchers, fellows and residents who are interested in or manage histiocytic disorders in children and adults.

Editors and Affiliations

  • University of Toronto, The Hospital for Sick Children, Toronto, Canada

    Oussama Abla

  • Pediatric Hematology and Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany

    Gritta Janka

About the editors

Oussama Abla, MD
Chair, Rare Histiocytoses Steering Committee- Histiocyte Society, Associate Professor of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, 
Canada


Gritta Janka, MD, PhD
Chair, HLH Steering Committee, Histiocyte Society, Professor emeritus of Pediatrics, University Medical Center Hamburg Eppendorf, Pediatric Hematology and Oncology, Hamburg, Germany

Bibliographic Information

  • Book Title: Histiocytic Disorders

  • Editors: Oussama Abla, Gritta Janka

  • DOI: https://doi.org/10.1007/978-3-319-59632-7

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing AG 2018

  • Hardcover ISBN: 978-3-319-59631-0Published: 07 December 2017

  • Softcover ISBN: 978-3-319-86667-3Published: 23 June 2018

  • eBook ISBN: 978-3-319-59632-7Published: 17 November 2017

  • Edition Number: 1

  • Number of Pages: XII, 392

  • Number of Illustrations: 22 b/w illustrations, 74 illustrations in colour

  • Topics: Hematology, Oncology, Pathology

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