Biomedical Technology

1. Front Matter

   Pages i-ix

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2. Biological Systems

   1. Front Matter

      Pages 1-1

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   2. Multiscale Aspects in the Multiphasic Modelling of Human Brain Tissue

      • Wolfgang Ehlers, Arndt Wagner

      Pages 3-13

   3. Simulation of Steatosis Zonation in Liver Lobule—A Continuummechanical Bi-Scale, Tri-Phasic, Multi-Component Approach

      • Tim Ricken, Navina Waschinsky, Daniel Werner

      Pages 15-33

   4. Nano-Mechanical Tensile Behavior of the SPTA1 Gene in the Presence of Hereditary Hemolytic Anemia-Related Point Mutations

      • Melis Hunt

      Pages 35-47

   5. The Choice of a Performance Indicator of Release in Transdermal Drug Delivery Systems

      • Giuseppe Pontrelli, Laurent Simon

      Pages 49-64

3. Cardiovascular Medicine

   1. Front Matter

      Pages 65-65

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   2. Multiscale Multiphysic Approaches in Vascular Hemodynamics

      • Michael Neidlin, Tim A S Kaufmann, Ulrich Steinseifer, Thomas Schmitz-Rode

      Pages 67-76

   3. Heart Valve Flow Computation with the Space–Time Slip Interface Topology Change (ST-SI-TC) Method and Isogeometric Analysis (IGA)

      • Kenji Takizawa, Tayfun E. Tezduyar, Takuya Terahara, Takafumi Sasaki

      Pages 77-99

   4. Estimation of Element-Based Zero-Stress State in Arterial FSI Computations with Isogeometric Wall Discretization

      • Kenji Takizawa, Tayfun E. Tezduyar, Takafumi Sasaki

      Pages 101-122

   5. Fluid-Structure Interaction Modeling in 3D Cerebral Arteries and Aneurysms

      • Yue Yu

      Pages 123-146

   6. Large-Eddy Simulation of Turbulence in Cardiovascular Flows

      • F. Nicoud, C. Chnafa, J. Siguenza, V. Zmijanovic, S. Mendez

      Pages 147-167

   7. Computational Comparison Between Newtonian and Non-Newtonian Blood Rheologies in Stenotic Vessels

      • Bruno Guerciotti, Christian Vergara

      Pages 169-183

   8. Artificial Textile Reinforced Tubular Aortic Heart Valves—Multi-scale Modelling and Experimental Validation

      • Deepanshu Sodhani, R. Varun Raj, Jaan Simon, Stefanie Reese, Ricardo Moreira, Valentine Gesché et al.

      Pages 185-215

   9. Preliminary Monolithic Fluid Structure Interaction Model for Ventricle Contraction

      • D. Cerroni, D. Giommi, S. Manservisi, F. Mengini

      Pages 217-231

   10. The Biomechanical Rupture Risk Assessment of Abdominal Aortic Aneurysms—Method and Clinical Relevance

       • T. Christian Gasser

       Pages 233-253

4. Dentistry

   1. Front Matter

      Pages 255-255

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   2. A Deeper Insight of a Multi-dimensional Continuum Biofilm Growth Model: Experimental Observation and Parameter Studies

      • Dianlei Feng, Henryke Rath, Insa Neuweiler, Nico Stumpp, Udo Nackenhorst, Meike Stiesch

      Pages 257-272

   3. Multiscale Experimental and Computational Investigation of Nature’s Design Principle of Hierarchies in Dental Enamel

      • Songyun Ma, Ingo Scheider, Ezgi D. Yilmaz, Gerold A. Schneider, Swantje Bargmann

      Pages 273-291

5. Orthopaedics

   1. Front Matter

      Pages 293-293

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This book provides an overview of new mathematical models, computational simulations and experimental tests in the field of biomedical technology, and covers a wide range of current research and challenges. The first part focuses on the virtual environment used to study biological systems at different scales and under multiphysics conditions. In turn, the second part is devoted to modeling and computational approaches in the field of cardiovascular medicine, e.g. simulation of turbulence in cardiovascular flow, modeling of artificial textile-reinforced heart valves, and new strategies for reducing the computational cost in the fluid-structure interaction modeling of hemodynamics. The book’s last three parts address experimental observations, numerical tests, computational simulations, and multiscale modeling approaches to dentistry, orthopedics and otology. Written by leading experts, the book reflects the remarkable advances that have been made in the field of medicine, the life sciences, engineering and computational mechanics over the past decade, and summarizes essential tools and methods (such as virtual prototyping of medical devices, advances in medical imaging, high-performance computing and new experimental test devices) to enhance medical decision-making processes and refine implant design. The contents build upon the International Conference on Biomedical Technology 2015 (ICTB 2015), the second ECCOMAS thematic conference on Biomedical Engineering, held in Hannover, Germany in October 2015.

• Computational Biomedical Mechanics
• Fluid-Structure Interaction
• Musculoskeletal Mechanics
• Computational Fluid Dynamics
• Cardiovascular Biomechanics
• Hearing Implants
• Tissue Multiscale Modeling
• Prosthetics Computational Mechanics
• Physiological Flows Modeling

• Institute of Continuum Mechanics, Leibniz Universität Hannover, Hannover, Germany

  Peter Wriggers

• Hals-Nasen-Ohrenklinik, Medical School Hannover, Hannover, Germany

  Thomas Lenarz

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