Overview
- Presents the latest advances concerning the regulation of chromosome segregation during cell division
- Covers state-of-the-art techniques employed in the field
- Incorporates a wealth of different model systems and species
Part of the book series: Progress in Molecular and Subcellular Biology (PMSB, volume 56)
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Table of contents (22 chapters)
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Front Matter
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Identification, Organization, and Regulation of Centromere and Kinetochore Components
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Front Matter
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Epigenetic Contributions to Centromere Identity and Function
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Front Matter
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The Role of DNA Sequence in Centromere Identity and Function
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Front Matter
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The Functions and Mechanisms of Centromeres and Kinetochores in Healthy Meiotic and Mitotic Divisions and their Role in Human Disease
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Front Matter
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Keywords
About this book
This book presents the latest advances concerning the regulation of chromosome segregation during cell division by means of centromeres and kinetochores. The authors cover both state-of-the-art techniques and a range of species and model systems, shedding new light on the molecular mechanisms controlling the transmission of genetic material between cell divisions and from parent to offspring.
The chapters cover five major areas related to the current study of centromeres and kinetochores: 1) their genetic and epigenetic features, 2) key breakthroughs at the molecular, proteomic, imaging and biochemical level, 3) the constitutive centromere proteins, 4) the role of centromere proteins in the physical process of chromosome segregation and its careful orchestration through elaborate regulation, and 5) intersections with reproductive biology, human health and disease, as well as chromosome evolution. The book offers an informative and provocative guide for newcomers as wellas those already acquainted with the field.
Editors and Affiliations
Bibliographic Information
Book Title: Centromeres and Kinetochores
Book Subtitle: Discovering the Molecular Mechanisms Underlying Chromosome Inheritance
Editors: Ben E. Black
Series Title: Progress in Molecular and Subcellular Biology
DOI: https://doi.org/10.1007/978-3-319-58592-5
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing AG 2017
Hardcover ISBN: 978-3-319-58591-8Published: 08 September 2017
Softcover ISBN: 978-3-319-86436-5Published: 10 August 2018
eBook ISBN: 978-3-319-58592-5Published: 23 August 2017
Series ISSN: 0079-6484
Series E-ISSN: 2197-8484
Edition Number: 1
Number of Pages: XI, 554
Number of Illustrations: 3 b/w illustrations, 98 illustrations in colour
Topics: Cell Cycle Analysis, Cell Physiology, Human Genetics