Overview
- Describes the role of SOCE pathways in health and disease
- Combines basic research with clinical aspects
- The second edition was updated with new discoveries in the field of structural biology, optogenetics and disease
- Introduces the most recent concepts of linkage between SOCE and mitochondrial Ca2+ signaling
- Gives insight into the newly identified molecular structure of the STIM-Orai machinery at the atomic resolution level
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 993)
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Table of contents (31 chapters)
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Front Matter
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SOCE: Fundamental Mechanistic Concepts
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Front Matter
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SOCE: Crosstalk Between Organelle and Cellular Compartments
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Front Matter
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Keywords
About this book
This second edition of the book on Store-operated Ca2+ Entry Pathways has been updated with the newest discoveries that emerged in the field within the last five years. The crystal structure of the Ca2+ signaling core complex is described which adds to a new understanding of the molecular interactions involved. Each chapter has been revised and extended. The book retains its interdisciplinary approach and supplies biochemists, cell biologists and biophysicists as well as clinicians in immunology, neurology and cardiology with valuable information on Ca2+ signaling mechanisms, functions, dysfunctions and their consequences.
Editors and Affiliations
About the editors
Prof. Klaus Groschner studied Pharmacy at the School of Pharmacy, University of Graz, Austria. He completed his PhD studies at the Department of Pharmacodynamics in Graz and received part of his postdoctoral education at the University of Miami, Florida, USA, studying electrophysiology and cell biology. In 1990 he became an Assistant Professor at the Department of Pharmacology and Toxicology and received his Habilitation in Pharmacology and Toxicology along with promotion to Associate Professor in 1993. Until 2011 he was head of a research unit for Physiology and Pharmacology of Membrane Transport at the Institute of Pharmaceutical Sciences at the University of Graz. Since 2012 he is Full Professor for Biophysics and Chairman at the Institute of Biophysics at the Medical University of Graz.
Prof. Wolfgang F. Graier studied Pharmacy at the University of Graz, Austria and received his PhD in Pharmacology at the Department of Pharmacology and Toxicology, Universityof Graz. In 1993, 1994 he was a postdoctoral research fellow, analyzing physiology and membrane biophysics at the Dalton Cardiovascular Research Center, University of Missouri, Columbia, USA. In 1994 he became an Assistant Professor at the Department of Medical Biochemistry, University of Graz. In 1995 he became Associate Professor (Habilitation) in Biochemical Pharmacology and in Physiology in 2001 at the Department of Medical Biochemistry, University of Graz. Since 2009 he is Full Professor for Molecular Biology and Chairman of the Institute of Molecular Biology and Biochemistry at the Medical University of Graz. Since 2015 he is also Head of the Nikon-Center of Excellence for Super-Resolution Microscopy: Cells & Organelles that is part of BioTechMed, the concerted research platform of the Medical University Graz, the University of Graz, and the Graz Technical University. In 2016 he co-founded a spin-off company named Next Generation Fluorescence Imaging, NGFI, (www.ngfi.eu).
Prof. Christoph Romanin studied Chemistry at the Technical University of Graz, Austria and completed his doctoral studies at the Department of Pharmacology and Toxicology, University of Graz. In 1986 he started with a post-doc position at the Institute of Biophysics of the University of Linz, Austria, where he became Professor in Biophysics (Habilitation) in 1993 and served as an Associate Professor since 1997. In 2001 he was a guest researcher at the NIA, the National Institute on Aging of the NIH in Bethesda, USA. Currently, he is vice-chairman of the institute and head of the Ion Channel Group at the Institute of Biophysics in Linz, Austria.
Bibliographic Information
Book Title: Store-Operated Ca²⁺ Entry (SOCE) Pathways
Book Subtitle: Emerging Signaling Concepts in Human (Patho)physiology
Editors: Klaus Groschner, Wolfgang F. Graier, Christoph Romanin
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-319-57732-6
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2017
Hardcover ISBN: 978-3-319-57731-9Published: 20 September 2017
Softcover ISBN: 978-3-319-86236-1Published: 10 August 2018
eBook ISBN: 978-3-319-57732-6Published: 12 September 2017
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 2
Number of Pages: XXIX, 645
Number of Illustrations: 22 b/w illustrations, 62 illustrations in colour
Topics: Cell Biology, Medical Biochemistry, Biological and Medical Physics, Biophysics, Cardiology