Overview
Gives a unique insight of the connection between protein structure and function of arrestin and its broad implications
Discussed are structure-based redesign of signalling proteins paves the way for novel approaches to gene therapy
Presents a unified view of the structural basis of the various branches of arrestin-mediated signalling
Includes supplementary material: sn.pub/extras
Includes supplementary material: sn.pub/extras
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Table of contents (19 chapters)
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Front Matter
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Localization of Functional Elements on Arrestins
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Front Matter
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Arrestin-Mediated Signaling and Biased Mutants
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Front Matter
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Keywords
About this book
Here arrestin functions are described primarily from the structural prospective. The book covers basal structure of arrestin proteins, receptor binding-induced conformational changes in arrestins, as well as the structure of “pre-activated” mutants. Particular focus is on the arrestin elements interacting with numerous binding partners, GPCRs and cytoplasmic signaling proteins. We expect that this information and insights will help to understand and exploit the phenomenon of signaling bias, which is a new promising direction in drug discovery.
The chapters are written by the world-class specialists in the field, mostly the people who actually contributed the data discussed. The book gives coherent historical prospective and describes the most recent findings.
The book would be particularly useful for scientists in academia and industry working in the fields of pharmacology, cell biology, structural biology, and drug discovery. We expect that the focus on the molecular basis of protein-protein interactions would help to develop novel tools for engaging this important type of targets for research and therapeutic purposes.
Editors and Affiliations
About the editor
Bibliographic Information
Book Title: The Structural Basis of Arrestin Functions
Editors: Vsevolod V. Gurevich
DOI: https://doi.org/10.1007/978-3-319-57553-7
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing AG 2017
Hardcover ISBN: 978-3-319-57552-0Published: 07 June 2017
Softcover ISBN: 978-3-319-86191-3Published: 02 August 2018
eBook ISBN: 978-3-319-57553-7Published: 24 May 2017
Edition Number: 1
Number of Pages: IX, 304
Number of Illustrations: 2 b/w illustrations, 51 illustrations in colour
Topics: Animal Biochemistry, Protein Science, Protein Structure