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Patient-Derived Mouse Models of Cancer

Patient-Derived Orthotopic Xenografts (PDOX)

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  • © 2017

Overview

Editors:
  1. Robert M. Hoffman

    1. University of California and AntiCancer Inc., San Diego, USA

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  • The first single source to provide information on technique and uses of mouse models of human patient tumors
  • Written by experts in the field
  • Provides practical applications of the models from drug discovery, genome analysis to personalized treatment

Part of the book series: Molecular and Translational Medicine (MOLEMED)

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-xvi
    Download chapter PDF

  2. In Memoriam: Jørgen Rygaard (1934–2016), Father of Patient-Derived Mouse Models of Cancer and Modern Cancer Research

    • Robert M. Hoffman
    Pages 1-6

  3. The Revival of Patient-Derived Xenograft Mouse Models of Cancer: Way Back to the Future

    • Robert M. Hoffman
    Pages 7-12

  4. Patient-Derived Xenograft Models for Human Cancer: The Freiburg Experience

    • Heinz-Herbert Fiebig
    Pages 13-41

  5. From Ectopic to Orthotopic Tumor Grafting Sites: Evidence for a Critical Role of the Host Tissue Microenvironment for the Actual Expression of the Malignant Phenotype

    • Bernard C. M. Sordat
    Pages 43-53

  6. The Effects of the Organ Microenvironment on Metastatic Cell Gene Signatures

    • Sun-Jin Kim, Ho Jeong Lee, Hyunkyung Yu, Sung II Choi, John Weinstein, Jing Wang et al.
    Pages 55-69

  7. Techniques for Surgical Orthotopic Implantation of Human Tumors to Immunodeficient Mice

    • Robert M. Hoffman
    Pages 71-78

  8. The First Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Cancer: Cancer of the Colon, Pancreas, Lung, Breast, Ovary, and Mesothelioma

    • Robert M. Hoffman
    Pages 79-87

  9. Patient-Derived Xenograft Models of Prostate Cancer

    • R. B. Marques, C. M. A. de Ridder, W. M. van Weerden
    Pages 89-112

  10. Patient-Derived Mouse Models of Sarcoma

    • Tara A. Russell, Irmina A. Elliott, Arun S. Singh, Fritz C. Eilber
    Pages 113-124

  11. Cervical Cancer PDOX Models

    • Robert M. Hoffman, Yukihiko Hiroshima, Takashi Murakami, Takuya Murata
    Pages 125-132

  12. The Use of Pediatric Patient-Derived Xenografts for Identifying Novel Agents and Combinations

    • Raushan T. Kurmasheva, Peter J. Houghton
    Pages 133-159

  13. Development of Orthotopic and Spontaneous Metastatic Human Tumor Xenograft Models for Experimental Therapeutics

    • Marta Paez-Ribes, Raquel Munoz, Eric Guerin, Shan Man, Ping Xu, John Ebos et al.
    Pages 161-182

  14. Use of Patient-Derived Orthotopic Xenografts (PDOX) to Evaluate Transformative Cancer Therapeutics

    • Robert M. Hoffman
    Pages 183-192

  15. Fluorescent Protein-Expressing Transgenic Nude Mice as Hosts for Patient Tumors

    • Robert M. Hoffman
    Pages 193-206

  16. Fluorescence Imaging of Tumors in Human Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models

    • Robert M. Hoffman, Atsushi Suetsugu, Tasuku Kiyuna, Shuya Yano, Michael Bouvet
    Pages 207-216

  17. The Use of Patient-Derived Orthotopic Xenograft (PDOX) Models to Develop Curative Fluorescence-Guided Surgery of Cancer

    • Robert M. Hoffman, Yukihiko Hiroshima, Shuya Yano, Cristina A. Metildi, Michael Bouvet
    Pages 217-226

  18. Molecular Characteristics of Patient-Derived Tumor Xenografts: Similarities to Patient Tumors and Relevance for Biomarker Discovery

    • Vincent Vuaroqueaux, Anne-Lise Peille, Bruno Zeitouni, Anne-Marie Eades-Perner, Heinz-Herbert Fiebig
    Pages 227-243

  19. Synergy of Patient-Derived Orthotopic Xenografts (PDOX) Models and Molecular Profiling for Optimal Therapy

    • Robert M. Hoffman, Takashi Murakami, Kei Kawaguchi, Arun S. Singh, Fritz C. Eilber
    Pages 245-250

  20. 3D Cell Culture Models

    • David M. Evans, Beverly A. Teicher
    Pages 251-275
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Keywords

About this book

This text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors. These areas include training, basic techniques, as well as general troubleshooting. Subsequent chapters focus on the different mouse models of patient tumors including the various strains of immunodeficient mice currently available and the transplantation techniques that can be used as well as state-of-the-art imaging techniques. Practical applications of the models from drug discovery, genome analysis to personalized treatment are also covered. Written by experts in that field, each of these sections address these critical issues. A brief review of the existing literature addressing the particular topic follows in each section.


Presently, there is no single source to provide information on technique and uses of mouse models of human patient tumors. Patient-Derived Mouse Models of Cancer will satisfy this need for cancer researchers, oncologists, pharmaceutical and biotechnology industry scientists as well as molecular biologists studying in vivo systems


Editors and Affiliations

  • University of California and AntiCancer Inc., San Diego, USA

    Robert M. Hoffman

About the editor

R.M. Hoffman has been a cancer researcher since 1965.  Dr. Hoffman is the pioneer of the patient-derived orthotopic xenograft (PDOX) mouse model, which is featured in the present volume.  Dr. Hoffman is a pioneer in many areas of cancer research described in his almost 1,000 scientific publications that have been cited more than 35,000 times with an h-index of almost 100.  Dr. Hoffman is currently a Professor of Surgery at the University of California San Diego and Founding President of AntiCancer Inc.

Bibliographic Information

  • Book Title: Patient-Derived Mouse Models of Cancer

  • Book Subtitle: Patient-Derived Orthotopic Xenografts (PDOX)

  • Editors: Robert M. Hoffman

  • Series Title: Molecular and Translational Medicine

  • DOI: https://doi.org/10.1007/978-3-319-57424-0

  • Publisher: Humana Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing AG 2017

  • Hardcover ISBN: 978-3-319-57423-3Published: 14 August 2017

  • Softcover ISBN: 978-3-319-86158-6Published: 15 June 2018

  • eBook ISBN: 978-3-319-57424-0Published: 01 August 2017

  • Series ISSN: 2197-7852

  • Series E-ISSN: 2197-7860

  • Edition Number: 1

  • Number of Pages: XVI, 296

  • Number of Illustrations: 10 b/w illustrations, 50 illustrations in colour

  • Topics: Oncology, Cancer Research

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