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Resistance to Molecular Therapies for Hepatocellular Carcinoma

  • Book
  • © 2017

Overview

Editors:
  1. Augusto Villanueva

    1. Division of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, Graduate School of Biomedical Sciences, New York, USA

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  • This book will evaluate the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold-standard to define radiological resistance
  • This book will describe the molecular mechanisms responsible for treatment resistance in HCC patients, including components of the immune system and tumor microenvironment
  • This book will help determine the role of the cancer stem cell phenotype in resistance
  • This book will review the experimental models to study resistance
  • This book will address new approaches to overcome resistance to sorafenib, using successful examples from other malignancies

Part of the book series: Resistance to Targeted Anti-Cancer Therapeutics (RTACT, volume 13)

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Tumor Heterogeneity and Resistance to Targeted Therapies in Hepatocellular Carcinoma

    • Amanda J. Craig, Ismail Labgaa, Carlos Villacorta-Martin, Massih Ningarhari, Augusto Villanueva
    Pages 1-24

  3. Modulating Immune Responses to Overcome Resistance in Hepatocellular Carcinoma

    • Delia D’Avola, Bruno Sangro
    Pages 25-43

  4. Role of Tumor Microenvironment in Hepatocellular Carcinoma Resistance

    • Leila Akkari, Amaia Lujambio
    Pages 45-64

  5. Contribution of the Cancer Stem Cell Phenotype to Hepatocellular Carcinoma Resistance

    • Darko Castven, Carolin Czauderna, Jens U. Marquardt
    Pages 65-91

  6. Clinical and Preclinical Perspectives on Mechanisms of Sorafenib Resistance in Hepatocellular Carcinoma

    • Chiun Hsu, Ann-Lii Cheng
    Pages 93-103

  7. Radiological Assessment of Response to Palliative Treatments in Hepatocellular Carcinoma

    • Riccardo Lencioni
    Pages 105-116

  8. Sorafenib and Clinical Patterns of Resistance in Hepatocellular Carcinoma

    • Maria Reig, Álvaro Díaz-Gonzalez, Andrea Ribeiro, Anna Darnell
    Pages 117-131

  9. Overcoming Treatment Resistance in Hepatocellular Carcinoma: Regorafenib and Lessons from Other Malignancies

    • Bingnan Zhang, Richard S. Finn
    Pages 133-142

  10. Back Matter

    Pages 143-147
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Keywords

About this book

This volume evaluates the clinical patterns of resistance to sorafenib, the impact of trial design in the second-line setting and the current gold standard to define radiological resistance; describes the molecular mechanisms responsible for treatment resistance in HCC patients, including components of the immune system and tumor microenvironment; determines the role of the cancer stem cell phenotype in resistance; reviews the experimental models to study resistance; and addresses new approaches to overcome resistance to sorafenib, using successful examples from other malignancies. 

Editors and Affiliations

  • Division of Liver Diseases, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, Graduate School of Biomedical Sciences, New York, USA

    Augusto Villanueva

About the editor

Augusto Villanueva, MD, PhD, is Assistant Professor, Division of Liver Diseases, Liver Cancer Program, Department of Medicine, Tisch Cancer Institute, Icahn School of Medicine, NYC.

Bibliographic Information

  • Book Title: Resistance to Molecular Therapies for Hepatocellular Carcinoma

  • Editors: Augusto Villanueva

  • Series Title: Resistance to Targeted Anti-Cancer Therapeutics

  • DOI: https://doi.org/10.1007/978-3-319-56197-4

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG 2017

  • Hardcover ISBN: 978-3-319-56196-7Published: 27 July 2017

  • Softcover ISBN: 978-3-319-85850-0Published: 02 August 2018

  • eBook ISBN: 978-3-319-56197-4Published: 14 July 2017

  • Series ISSN: 2196-5501

  • Series E-ISSN: 2196-551X

  • Edition Number: 1

  • Number of Pages: XIII, 147

  • Number of Illustrations: 16 illustrations in colour

  • Topics: Cancer Research

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