Oral Mucosa in Health and Disease

1. Front Matter

   Pages i-xi

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2. Structure and Functions of the Oral Mucosa

   • Alan T. Cruchley, Lesley Ann Bergmeier

   Pages 1-18

3. Cell-Cell Interactions in the Oral Mucosa: Tight Junctions and Gap Junctions

   • Hong Wan, Hanan Gadmor, Louise Brown

   Pages 19-30

4. Anchoring Junctions in the Oral Mucosa: Adherens Junctions and Desmosomes

   • Hong Wan, Hanan Gadmor, Louise Brown

   Pages 31-51

5. Immunology of the Oral Mucosa

   • Lesley Ann Bergmeier

   Pages 53-67

6. Mucosal Homeostasis of the Oral Mucosa

   • Jean-Pierre Allam, Natalija Novak

   Pages 69-76

7. Wound Healing in the Oral Mucosa

   • Patricio C. Smith, Constanza Martínez

   Pages 77-90

8. Saliva and Gingival Crevicular Fluid: Contributions to Mucosal Defense

   • Hayder F. Saloom, Guy H. Carpenter

   Pages 91-103

9. Oral Cancer: Recent Developments and Future Challenges

   • E. Kenneth Parkinson

   Pages 105-118

10. Epigenetics in the Oral Cavity

    • Lena Larsson

    Pages 119-125

11. Infections of the Oral Mucosa and Immune Responses

    • Lesley Ann Bergmeier

    Pages 127-140

12. Non-infectious Diseases of the Oral Mucosa: The Importance of Immune Functions

    • Lesley Ann Bergmeier, Farida Fortune

    Pages 141-159

13. Clinical Management of Oral Mucosal Disease: A Literature Review

    • Lesley Ann Bergmeier, Farida Fortune

    Pages 161-171

14. Future Directions of Research in the Oral Mucosa

    • Lesley Ann Bergmeier, E. Kenneth Parkinson

    Pages 173-184

This book is designed to re-establish the position of the oral cavity and its mucosa at the forefront of defence and maintenance of homeostatic mechanisms that protect against disease not just locally but also systemically. The oral mucosa is a unique collection of tissues that constitutes a highly active environment with its own unique microflora and homeostatic interaction with the innate and adaptive immune responses. As an immune tissue the oral mucosa was somewhat neglected in the past owing to the tendency to assume similarity to the gut mucosa. More recently it has become apparent that the oral mucosa is a complex environment and, like the esophageal mucosa, has more in common with vaginal tissue than with the gut. Furthermore, the ability of the oral mucosa to act as an immune inductive site has made it an attractive area of research in terms of desensitization for allergic reactions and possibly autoimmune responses. In this book, recognized experts in the field provide up-to-date coverage of all aspects of the structure and function of the oral mucosa, reflecting important recent advances in knowledge, including at the molecular level. 

• Oral Microbiome
• Oral Immunity
• Oral Barrier Function
• Oral Epithelium
• Oral Pathology

• Centre for Oral Immunobiology and Regenerative Medicine Institute of Dentistry, Queen Mary School of Medicine and Dentistry, London, United Kingdom

  Lesley Ann Bergmeier

Lesley Ann Bergmeier, MRSB, CBiol, PhD, PGCAP, FHEA, is Reader in Oral Immunology at the Centre for Oral Immunology and Regenerative medicine , Barts and The London, Queen Mary’s Schools of Medicine and Dentistry, London, UK. She was also Honorary Visiting Senior Lecturer in the Department of Oral Medicine and Pathology at King’s College London, Dental Institute at Guy’s Hospital (2007-2011). Dr. Bergmeier is an elected member of both the Royal Society of Biology (MSB) and the Institute of Biology (with designated status as a Chartered Biologist). In 2009 and 2014 she served as a member of the Scientific Advisory Committee for the World Workshop in Oral Health and AIDS. Dr. Bergmeier is a member of the editorial board of the International Journal of Experimental Dental Science. She is the author of 75 peer-reviewed papers cited in PubMed including eight reviews, as well as five book chapters, and has an H-index of 30. 

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