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Isolation and Molecular Characterization of Circulating Tumor Cells

  • Book
  • © 2017

Overview

Editors:
  1. Mark Jesus M. Magbanua

    1. University of California San Francisco, San Francisco, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. John W. Park

    1. University of California San Francisco, San Francisco, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Informative and authoritative, this book presents state-of-the-art strategies for CTC research from experts and key opinion leaders in the field
  • This book contains creative and innovative ideas for rare-cell detection and isolation
  • This book offers comprehensive discussions on the current understanding of the molecular biology of CTCs, as well as highly advanced and in-depth approaches for molecular characterization of these cells
  • TThis book includes discussions on the potential clinical utility of CTCs and how these cells may be incorporated into routine medical practice and personalized medicine

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 994)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xvi
    Download chapter PDF

  2. Circulating Tumor Cells as Cancer Biomarkers in the Clinic

    • Ludmilla Thomé Domingos Chinen, Emne Ali Abdallah, Alexcia Camila Braun, Bianca de Cássia Troncarelli de Campos Parra Flores, Marcelo Corassa, Solange Moraes Sanches et al.
    Pages 1-41

  3. Strategies for Isolation and Molecular Profiling of Circulating Tumor Cells

    • Jia-Yang Chen, Ying-Chih Chang
    Pages 43-66

  4. Aptamer-Based Methods for Detection of Circulating Tumor Cells and Their Potential for Personalized Diagnostics

    • Anna S. Zamay, Galina S. Zamay, Olga S. Kolovskaya, Tatiana N. Zamay, Maxim V. Berezovski
    Pages 67-81

  5. Development of a Protocol for Single-Cell Analysis of Circulating Tumor Cells in Patients with Solid Tumors

    • Carolina Reduzzi, Rosita Motta, Giulia Bertolini, Patrizia Miodini, Antonia Martinetti, Elisa Sottotetti et al.
    Pages 83-103

  6. Flow Cytometric Methods for Circulating Tumor Cell Isolation and Molecular Analysis

    • Neha Bhagwat, Erica L. Carpenter
    Pages 105-118

  7. Enrichment and Detection of Circulating Tumor Cells and Other Rare Cell Populations by Microfluidic Filtration

    • Michael Pugia, Mark Jesus M. Magbanua, John W. Park
    Pages 119-131

  8. Detection and Enumeration of Circulating Tumor Cells with Invasive Phenotype

    • Haizhen Wang, Xiangwei Wu
    Pages 133-141

  9. Molecular Profiling and Significance of Circulating Tumor Cell Based Genetic Signatures

    • Nisha Kanwar, Susan J. Done
    Pages 143-167

  10. Detection of Gene Rearrangements in Circulating Tumor Cells: Examples of ALK-, ROS1-, RET-Rearrangements in Non-Small-Cell Lung Cancer and ERG-Rearrangements in Prostate Cancer

    • Cyril Catelain, Emma Pailler, Marianne Oulhen, Vincent Faugeroux, Anne-Laure Pommier, Françoise Farace
    Pages 169-179

  11. Enrichment, Isolation and Molecular Characterization of EpCAM-Negative Circulating Tumor Cells

    • Rita Lampignano, Helen Schneck, Martin Neumann, Tanja Fehm, Hans Neubauer
    Pages 181-203

  12. Expression of Epithelial Mesenchymal Transition and Cancer Stem Cell Markers in Circulating Tumor Cells

    • Stefan Werner, Arnulf Stenzl, Klaus Pantel, Tilman Todenhöfer
    Pages 205-228

  13. Mesenchymal-Epithelial Transition and Circulating Tumor Cells in Small Cell Lung Cancer

    • Gerhard Hamilton, Barbara Rath
    Pages 229-245

  14. Clinical Relevance of a Candidate Stem Cell Marker, p75 Neurotrophin Receptor (p75NTR) Expression in Circulating Tumor Cells

    • Tomoyuki Okumura, Tetsuji Yamaguchi, Toru Watanabe, Takuya Nagata, Yutaka Shimada
    Pages 247-254

  15. Personalized Treatment Through Detection and Monitoring of Genetic Aberrations in Single Circulating Tumor Cells

    • Swee Jin Tan, Trifanny Yeo, Sarvesh Abhay Sukhatme, Say Li Kong, Wan-Teck Lim, Chwee Teck Lim
    Pages 255-273

  16. Glycan Markers as Potential Immunological Targets in Circulating Tumor Cells

    • Denong Wang, Lisa Wu, Xiaohe Liu
    Pages 275-284

  17. Significance of EGFR Expression in Circulating Tumor Cells

    • María José Serrano, María Jesús Alvarez-Cubero, Diego De Miguel Pérez, Alba Rodríguez-Martínez, Lucas Gonzalez-Herrera, Inmaculada Robles-Fernandez et al.
    Pages 285-296

  18. Back Matter

    Pages 297-301
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Keywords

About this book

Numerous studies have shown that elevated levels of circulating tumor cells (CTCs) in blood of cancer patients are associated with poor response to treatment and inferior survival probabilities. Despite this clinical significance, the molecular biology of CTCs remains poorly understood. The paucity in molecular information can be attributed to the tremendous technical challenges involved in isolating these extremely rare cells. Recent technological advancements in rare-cell technology, however, have allowed for the reliable enrichment and isolation of CTCs. Consequently, the use of recently developed molecular approaches —e.g., multiplexed QPCR, microarray, and next generation sequencing analyses— to profile CTCs have provided novel insights into the molecular makeup of these tumor cells. This book discusses approaches for enrichment and isolation of CTCs as well as recent advances in comprehensive molecular profiling of CTCs using cutting-edge omics technology.

Editors and Affiliations

  • University of California San Francisco, San Francisco, USA

    Mark Jesus M. Magbanua, John W. Park

Bibliographic Information

  • Book Title: Isolation and Molecular Characterization of Circulating Tumor Cells

  • Editors: Mark Jesus M. Magbanua, John W. Park

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-319-55947-6

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2017

  • Hardcover ISBN: 978-3-319-55946-9Published: 08 June 2017

  • Softcover ISBN: 978-3-319-85787-9Published: 02 August 2018

  • eBook ISBN: 978-3-319-55947-6Published: 29 May 2017

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XVI, 301

  • Number of Illustrations: 27 b/w illustrations, 15 illustrations in colour

  • Topics: Cancer Research

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