Glial Amino Acid Transporters

1. Front Matter

   Pages i-xii

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2. Manganese Control of Glutamate Transporters’ Gene Expression

   • Eunsook Lee, Pratap Karki, James Johnson Jr, Peter Hong, Michael Aschner

   Pages 1-12

3. Glycine Transporters in Glia Cells: Structural Studies

   • Beatriz López-Corcuera, Cristina Benito-Muñoz, Carmen Aragón

   Pages 13-32

4. Taurine Homeostasis and Volume Control

   • Herminia Pasantes-Morales

   Pages 33-53

5. Glycine Transporters and Its Coupling with NMDA Receptors

   • Francisco Zafra, Ignacio Ibáñez, David Bartolomé-Martín, Dolores Piniella, Marina Arribas-Blázquez, Cecilio Giménez

   Pages 55-83

6. Revised Ion/Substrate Coupling Stoichiometry of GABA Transporters

   • Sepehr Eskandari, Samantha L. Willford, Cynthia M. Anderson

   Pages 85-116

7. EAAT2 and the Molecular Signature of Amyotrophic Lateral Sclerosis

   • Lauren Taylor Rosenblum, Davide Trotti

   Pages 117-136

8. Glial GABA Transporters as Modulators of Inhibitory Signalling in Epilepsy and Stroke

   • Maria E. K. Lie, Anas Al-Khawaja, Maria Damgaard, Anne S. Haugaard, Arne Schousboe, Andrew N. Clarkson et al.

   Pages 137-167

9. Glutamine/Glutamate Transporters in Glial Cells: Much More Than Participants of a Metabolic Shuttle

   • Angelina Rodríguez, Arturo Ortega

   Pages 169-183

10. Glial Glutamate Transporters as Signaling Molecules

    • Edna Suárez-Pozos, Donají Chi-Castañeda, Arturo Ortega

    Pages 185-198

11. Regulation of Glutamate Transporter Expression in Glial Cells

    • Donají Chi-Castañeda, Edna Suárez-Pozos, Arturo Ortega

    Pages 199-224

12. Glutamate Transport System as a Novel Therapeutic Target in Chronic Pain: Molecular Mechanisms and Pharmacology

    • Georgi Gegelashvili, Ole Jannik Bjerrum

    Pages 225-253

13. Molecular Characteristics, Regulation, and Function of Monocarboxylate Transporters

    • Roberto Elizondo-Vega, María Angeles García-Robles

    Pages 255-267

14. Glial Excitatory Amino Acid Transporters and Glucose Incorporation

    • Germán Fernando Gutiérrez Aguilar, Ivan Alquisiras-Burgos, Mónica Espinoza-Rojo, Penélope Aguilera

    Pages 269-282

15. Astrocytic GABA Transporters: Pharmacological Properties and Targets for Antiepileptic Drugs

    • Arne Schousboe, Petrine Wellendorph, Bente Frølund, Rasmus P. Clausen, Povl Krogsgaard-Larsen

    Pages 283-296

16. Glutamate Transporters in the Blood-Brain Barrier

    • Hans Christian Cederberg Helms, Carsten Uhd Nielsen, Helle Sønderby Waagepetersen, Birger Brodin

    Pages 297-314

17. Development of Non-GAT1-Selective Inhibitors: Challenges and Achievements

    • Maria Damgaard, Anne Stæhr Haugaard, Stefanie Kickinger, Anas Al-Khawaja, Maria E. K. Lie, Gerhard F. Ecker et al.

    Pages 315-332

18. Back Matter

    Pages 333-341

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This ambitious compendium provides an extensive overview on the "supporting cells" of the vertebrate central nervous system, these being glial cells which far outnumber neurons but are much less understood. Covering multiple aspects of this family of transporters-- from structural properties, to their involvement in signaling and gene expression regulation, this volume presents the most recent research on the roles of glial amino acid transporters as key molecules of brain metabolism and signaling. 

• Amino Acid Transporters
• GABA
• Gene Expression Regulation
• Glia Cells
• Signaling

• Department of Toxicology, Cinvestav-IPN México City, México, Mexico

  Arturo Ortega

• Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

  Arne Schousboe

Arturo Ortega holds a B.Sc. degree in Chemistry from The National Autonomous University of Mexico  (1985),  a M. Sc. in Physiology  from Cinvestav, Mexico City  (1985) and a Ph.D. in Neurobiology (1991) from The Weizmann Institute of Science in Rehovot, Israel, under the supervision of the late Vivian I. Teichberg with whom he started to work in glutamate-mediated signaling in glia cells.   After spending 2 years in the Department of Biochemistry in Cinvestav as an Assistant Professor, he moved to the Department of Genetics and Molecular Biology where he was promoted to Associate Professor in 1997 and in 2004 to the rank of Professor.  More recently (2013) he moved to the Department of Toxicology where he established a Neurotoxicology Lab. He has been Visiting Professor in the Institute of Neuroscience of the Autonomous University of Barcelona (2008)  and in the Catholic University of Louvain (2014-2015). He  served as the Department Chair (Genetics and Molecular Biology). Hehas been working on glutamate receptors and transporters focusing on signaling, gene expression regulation at the transcriptional and translational levels for more than 30 years.  He has published over 100 research articles and mentored 33 PhD and 67 MSc students. He is currently member of the Editorial Board of the two major Neurochemistry journals and of the book series Advances in Neurobiology.

Arne Schousboe obtained his M.Sc. in biochemistry from The University of Copenhagen in 1968 at a time where an M. Sc. was considered equivalent to a Ph.D. He subsequently (1978) earned his Doctor of Science (D. Sc.) degree also from University of Copenhagen. After a post-doc period with Dr. Eugene Roberts at the Department of Neuroscience, City of Hope National Medical Center in Los Angeles 1972-1973 he came back to the University of Copenhagen to resume a tenured position as Assoc. Prof. at the Medical Faculty. In 1990 he moved to the Royal Danish School of Pharmacy, Copenhagenas a Full Professor of biochemistry and has remained in this position also when this Institution changed to become an independent University and subsequently a Faculty of Pharmaceutical Sciences which lately was incorporated in the Faculty of Health and Medical Sciences still at the University of Copenhagen . He has served as the Department Chair from 2005 to 2010 and is now part time Professor of Neuropharmacology in Department of Drug Design and Pharmacology at University of Copenhagen. He has been working on astrocyte function focusing on amino acid neurotransmission during the past more than 4o years and is currently engaged in studies of glutamate and GABA homeostasis and metabolism. He has published over 550 papers on these and related topics. He has served on the Editorial Board on numerous neuroscience journals over the years and is currently the Editor-in-Chief of Neurochemical Research and Editor of the book series Advances in Neurobiology

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