Antiphospholipid Syndrome

1. Front Matter

   Pages i-xx

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2. Historical Aspects of Antiphospholipid Syndrome

   1. Front Matter

      Pages 1-1

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   2. History of Antiphospholipid Antibody

      • Michael D. Lockshin, E. Nigel Harris

      Pages 3-11

3. Basic Science Aspects of Antiphospholipid Syndrome

   1. Front Matter

      Pages 13-13

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   2. Natural Proteins Involved in Antiphospholipid Syndrome

      • Philip G. de Groot, Bas de Laat, Jacob Rand, Panayiotis G. Vlachoyiannopoulos, Fatima El-Assaad, Steven A. Krilis et al.

      Pages 15-27

   3. Origin of Antiphospholipid Antibodies

      • Joyce Rauch, Miri Blank, Philip G. de Groot, Kathryn M. Dupnik, Martin Alexander Kriegel, Jerrold S. Levine et al.

      Pages 29-52

   4. Recent Advances in Understanding of the Genetics of Antiphospholipid Syndrome

      • Niti Goel, Thomas L. Ortel

      Pages 53-75

   5. Mechanisms of Antiphospholipid Antibody-Mediated Thrombosis

      • Rohan Willis, Hannah Cohen, Ian Giles, Jason S. Knight, Steven A. Krilis, Anisur Rahman et al.

      Pages 77-116

   6. Mechanisms of Antiphospholipid Antibody-Mediated Pregnancy Morbidity

      • Jane E. Salmon, Chieko Mineo, Ian Giles, Larry W. Chamley, Pier Luigi Meroni, Vikki M. Abrahams

      Pages 117-143

4. Clinical and Diagnostic Aspects of Antiphospholipid Syndrome

   1. Front Matter

      Pages 145-145

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   2. Definition and Epidemiology of Antiphospholipid Syndrome

      • Ozan Unlu, Vinicius Domingues, Guilherme Ramires de Jesús, Stéphane Zuily, Gerard Espinosa, Ricard Cervera et al.

      Pages 147-169

   3. Clinical and Prognostic Significance of Non-criteria Antiphospholipid Antibody Tests

      • Maria Laura Bertolaccini, Olga Amengual, Bahar Artim-Eser, Tatsuya Atsumi, Philip G. de Groot, Bas de Laat et al.

      Pages 171-187

   4. Disease and Risk Measurement Criteria in Antiphospholipid Syndrome

      • Mary-Carmen Amigo, Kenji Oku, Savino Sciascia, María Victoria Goycochea Robles, Stéphane Zuily, Olga Amengual et al.

      Pages 189-199

   5. Neuropsychiatric Manifestations of Antiphospholipid Syndrome

      • Cécile M. Yelnik, Simone Appenzeller, Giovanni Sanna, Elizabeth Kozora, Maria Laura Bertolaccini

      Pages 201-219

5. Therapeutic Aspects of Antiphospholipid Syndrome

   1. Front Matter

      Pages 221-221

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   2. Prevention and Treatment of Thrombotic Antiphospholipid Syndrome

      • Mark Crowther, Kimberly J. Legault, David A. Garcia, Maria G. Tektonidou, Amaia Ugarte, Ian N. Bruce et al.

      Pages 223-233

   3. Prevention and Treatment of Obstetric Antiphospholipid Syndrome

      • Guilherme Ramires de Jesús, Karen J. Gibbins, Robert M. Silver, D. Ware Branch

      Pages 235-246

   4. Treatment of Non-criteria Manifestations in Antiphospholipid Syndrome

      • Michelle Remião Ugolini-Lopes, Paulo Ricardo Criado, Kurosh Parsi, Reyhan Diz Kucukkaya, Mary-Carmen Amigo, Maria G. Tektonidou et al.

      Pages 247-266

   5. Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking (APS ACTION)

      • Medha Barbhaiya, Danieli Andrade, Maria Laura Bertolaccini, Doruk Erkan

      Pages 267-276

6. 15th International Congress on Antiphospholipid Antibodies Task Force Reports

   1. Front Matter

      Pages 277-277

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This new edition is a comprehensive and updated resource on antiphospholipid syndrome (APS), which is an autoimmune disorder. In APS, the body recognizes certain normal components of blood and/or cell membranes as foreign substances and produces antibodies (antiphospholipid antibodies) against them. APS is associated with recurrent clotting events (thrombosis) including premature stroke, repeated miscarriages, phlebitis, venous thrombosis, and pulmonary thromboembolism. It is also associated with low platelet or blood elements that prevent bleeding. Recently, however, even more disease states have been linked with APS, including premature heart attack, various cardiac valvular abnormalities, skin lesions, kidney disease, abnormal involuntary movement/chorea, diseases that mimic multiple sclerosis, and vascular diseases of the eye that can lead to visual loss and blindness. The International Congress on Antiphospholipid Antibodies, held every 3 years, is the venue where representatives from different disciplines gather to discuss the recent advances in APS. The conference intends to cover basic aspects of APS, such as pathogenesis, origins, genetics, intracellular and molecular events, the role of infections, as well as traditional and non-traditional clinical manifestations associated with antiphospholipid antibodies. The 15th Congress took place in September 2016. A novel aspect of the Congress was that multiple teams, chaired by Scientific Planning Committee members, used evidence-based literature reviews and expert discussions to answer specific pre-defined APS-related questions. These teams included points of view from experts in rheumatology, hematology, cardiovascular medicine, obstetrics, neurology, and immunology. The Scientific Planning Committee members also chaired the congress sessions and supervised completion of the reports that are the bases of the chapters of this book. In addition, there are two chapters included specifically written for APS patients. Much like the previous volume, dedicated to the 13th International Congress on Antiphospholipid Antibodies (April 2010), this up-to-date and comprehensive work gathers invaluable insights from a multidisciplinary team of world-renowned experts and represents the authoritative resource on causes, symptoms, diagnosis, and treatment of APS.​​

• antiphospholipid antibody
• antiphospholipid syndrome
• autoimmune disorder
• obstetric antiphospholipid syndrome
• pulmonary thromboembolism
• thrombosis

• The Barbara Volcker Center for Women and Rheumatic Diseases, Associate Attending Physician, Hospital for Special Surgery, Associate Professor of Medicine, Weill Cornell Medicine, New York, USA

  Doruk Erkan

• The Barbara Volcker Center for Women and Rheumatic Diseases, Attending Physician, Hospital for Special Surgery, Professor of Medicine and Obstetrics-Gynecology, Weill Cornell Medicine, New York, USA

  Michael D. Lockshin

Doruk Erkan, MD, MPH, Associate Attending Physician, Associate Professor of Medicine, Department of Rheumatology, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, USA, Michael D. Lockshin, MD, Attending Physician, Professor of Medicine and Obstetrics-Gynecology, Department of Rheumatology, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, USA

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