Microdomains in the Cardiovascular System

1. Front Matter

   Pages i-viii

   PDF

2. Cyclic Nucleotide Microdomains

   1. Front Matter

      Pages 1-1

      PDF

   2. Receptor-Cyclic Nucleotide Microdomains in the Heart

      • Nadja I. Bork, Viacheslav O. Nikolaev

      Pages 3-15

   3. Membrane Microdomains and cAMP Compartmentation in Cardiac Myocytes

      • Shailesh R. Agarwal, Rennolds S. Ostrom, Robert D. Harvey

      Pages 17-35

   4. Function to Failure: Compartmentalization of Cardiomyocyte Signaling by A-Kinase-Anchoring Proteins

      • John M. Redden, Kimberly L. Dodge-Kafka, Michael S. Kapiloff

      Pages 37-57

   5. Pharmacological Approaches for Delineating Functions of AKAP-Based Signalling Complexes and Finding Therapeutic Targets

      • Katharina Schrade, Enno Klussmann

      Pages 59-83

   6. Chatting Second Messengers: PIP3 and cAMP

      • Alessandra Ghigo, Flora Pirozzi, Mingchuan Li, Emilio Hirsch

      Pages 85-95

   7. Cyclic Nucleotide Phosphodiesterases and Compartmentation in Normal and Diseased Heart

      • Ibrahim Bedioune, Pierre Bobin, Jérôme Leroy, Rodolphe Fischmeister, Grégoire Vandecasteele

      Pages 97-116

   8. cAMP Compartmentalisation and Hypertrophy of the Heart: ‘Good’ Pools of cAMP and ‘Bad’ Pools of cAMP Coexist in the Same Cardiac Myocyte

      • Anna Zoccarato, Manuela Zaccolo

      Pages 117-141

   9. Subcellular Targeting of PDE4 in Cardiac Myocytes and Generation of Signaling Compartments

      • Marco Conti

      Pages 143-160

   10. Cardiac cAMP Microdomains and Their Modulation Using Disruptor Peptides

       • Lauren Wills, Bracy A. Fertig, George S. Baillie

       Pages 161-173

   11. Computational Modeling of Cyclic Nucleotide Signaling Mechanisms in Cardiac Myocytes

       • Claire Y. Zhao

       Pages 175-213

   12. Signalling Microdomains: The Beta-3 Adrenergic Receptor/NOS Signalosome

       • J. Hammond, J.-L. Balligand

       Pages 215-244

   13. Compartmentation of Natriuretic Peptide Signalling in Cardiac Myocytes: Effects on Cardiac Contractility and Hypertrophy

       • Lise Román Moltzau, Silja Meier, Kjetil Wessel Andressen, Finn Olav Levy

       Pages 245-271

   14. Cyclic GMP/Protein Kinase Localized Signaling and Disease Implications

       • Brian Leei Lin, David A. Kass, Dong I. Lee

       Pages 273-290

3. Calcium Microdomains

   1. Front Matter

      Pages 291-291

      PDF

   2. Distribution and Regulation of L-Type Ca2+ Channels in Cardiomyocyte Microdomains

      • Alexey V. Glukhov, Anamika Bhargava, Julia Gorelik

      Pages 293-319

   3. The Role of Local Ca2+ Release for Ca2+ Alternans and SR-Ca2+ Leak

      • Karin P. Hammer, Lars S. Maier

      Pages 321-340

   4. The Control of Sub-plasma Membrane Calcium Signalling by the Plasma Membrane Calcium ATPase Pump PMCA4

      • Nicholas Stafford, Ludwig Neyses, Delvac Oceandy

      Pages 341-359

   5. Calcium Microdomains in Cardiac Cells

      • A. M. Gómez, T. R. R. Mesquita, J. J. Mercadier, J. L. Álvarez, J. P. Benitah

      Pages 361-386

The book comprehensively presents new findings in cardiovascular research related to signaling microdomains in health and disease. Important second messengers such as cAMP, cGMP, calcium and their role in microdomain signaling are discussed. The book offers and explains methodical approaches and technical ways how to successfully analyze microdomain signaling, also in the context of disease. It further provides scientific perspectives and strategies that are based on the concept of signaling within microdomains and that can revolutionize pharmacology and eventually lead to the effective treatment of cardiovascular diseases in future.
This book is written for scientists in cardiovascular research, pharmacology, molecular and cellular biology as well as medical doctors in cardiology, angiology and nephrology. 

• microdomain
• signaling
• cardiovascular
• cardiomyocyte
• second messenger

• Institute of Experimental Cardiovascular Research, University Medical Center, Hamburg-Eppendorf, Germany

  Viacheslav Nikolaev

• Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK

  Manuela Zaccolo

Prof. Viacheslav Nikolaev, PhD is the Director of the Institute of Experimental Cardiovascular Research at the University Medical Center Hamburg-Eppendorf, Germany. He is also a member of the German Center for Cardiovascular Research (DZHK). His main interest is live-cell imaging of cardiac cAMP and cGMP microdomains and their role in heart failure.

 

Prof. Manuela Zaccolo, MD is the Director of the Burdon Sanderson Cardiac Science Centre and works in the Department of Physiology, Anatomy and Genetics at the University of Oxford. She is interested in the regulatory principles by which intracellular signalling networks achieve the plasticity and context-sensitivity necessary for a cell to function. A central topic of her research is the role of local regulation of cyclic nucleotide signalling in healthy and diseased hearts.   

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