Macrophages

1. Front Matter

   Pages i-x

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2. Evolution, Origin and Fate of Macrophages

   1. Front Matter

      Pages 1-1

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   2. Evolutionary Aspects of Macrophages Polarization

      • Eva-Stina Edholm, Kun Hyoe Rhoo, Jacques Robert

      Pages 3-22

   3. Development and Functional Differentiation of Tissue-Resident Versus Monocyte-Derived Macrophages in Inflammatory Reactions

      • Paola Italiani, Diana Boraschi

      Pages 23-43

   4. Hofbauer Cells: Placental Macrophages of Fetal Origin

      • Leticia Reyes, Bryce Wolfe, Thaddeus Golos

      Pages 45-60

   5. Mesenchymal Stem Cells Direct the Immunological Fate of Macrophages

      • Patricia Luz-Crawford, Christian Jorgensen, Farida Djouad

      Pages 61-72

   6. Monocyte/Macrophage: NK Cell Cooperation—Old Tools for New Functions

      • Elżbieta Wałajtys-Rode, Jolanta M. Dzik

      Pages 73-145

   7. Macrophages in Invertebrates: From Insects and Crustaceans to Marine Bivalves

      • Prasad Abnave, Xavier Muracciole, Eric Ghigo

      Pages 147-158

3. Immunobiology of Macrophages

   1. Front Matter

      Pages 159-159

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   2. F4/80 as a Major Macrophage Marker: The Case of the Peritoneum and Spleen

      • Alexandra dos Anjos Cassado

      Pages 161-179

   3. Immunobiology of Nitric Oxide and Regulation of Inducible Nitric Oxide Synthase

      • Martin Lee, Kevin Rey, Katrina Besler, Christine Wang, Jonathan Choy

      Pages 181-207

   4. Role for Mechanotransduction in Macrophage and Dendritic Cell Immunobiology

      • Svenja F. B. Mennens, Koen van den Dries, Alessandra Cambi

      Pages 209-242

4. Role of Macrophages in Disease

   1. Front Matter

      Pages 243-243

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   2. Macrophages’ Role in Tissue Disease and Regeneration

      • Lewis Gaffney, Paul Warren, Emily A. Wrona, Matthew B. Fisher, Donald O. Freytes

      Pages 245-271

   3. Macrophages and Their Contribution to the Development of Atherosclerosis

      • Yuri V. Bobryshev, Nikita G. Nikiforov, Natalia V. Elizova, Alexander N. Orekhov

      Pages 273-298

   4. Macrophage Dysfunction in Respiratory Disease

      • Kylie B. R. Belchamber, Louise E. Donnelly

      Pages 299-313

5. Macrophages as a Target for Biointervention

   1. Front Matter

      Pages 315-315

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   2. Activation of Macrophages in Response to Biomaterials

      • Jamie E. Rayahin, Richard A. Gemeinhart

      Pages 317-351

   3. Macrophage Differentiation in Normal and Accelerated Wound Healing

      • Girish J. Kotwal, Sufan Chien

      Pages 353-364

   4. Macrophages and RhoA Pathway in Transplanted Organs

      • Yianzhu Liu, Jacek Z. Kubiak, Xian C. Li, Rafik M. Ghobrial, Malgorzata Kloc

      Pages 365-376

This volume gives a state-of-the-art overview on macrophage functions in various invertebrate and vertebrate systems and diseases. It also covers various aspects of macrophage development and formation, behavior and response to nano- and biomaterials, the latter of which have become very important components of modern medicine. 

Macrophages are evolutionarily conserved phagocytotic cells. In recent years macrophages have emerged as one of the most versatile cells of immune system, which, depending on the milieu and circumstance, participate in development or inhibition of cancer, regeneration, wound healing, inflammation, organ rejection and interaction between mother and a fetus.

This book will be of particular interest to researchers working in immunology, cancer research, developmental biology, or related fields.

• Macrophage
• Phagocytosis
• Immune response
• Macrophage differentiation
• Cancer development
• Cancer inhibition

• Department of Surgery, The Houston Methodist Hospital, Houston, USA

  Malgorzata Kloc

Prior to completing her postdoctoral training in Canada, Dr. Kloc was a tenured Associate Professor in the Department of Zoology at the University of Warsaw, Poland. She also served as a Research Associate in the Department of Biology at Carleton University in Ottawa, Canada. While completing her postdoctoral training, Dr. Kloc earned the AHFMR Research Award from the University of Calgary and the MRC Biotechnology Training Award from Dalhousie University. She joined the University of Texas M.D. Anderson Cancer Center as a Research Scientist in the Department of Molecular Genetics in 1987, and became an Associate Professor in the Department of Biochemistry and Molecular Biology there in 2006. Dr. Kloc joined the Houston Methodist Research Institute in 2008. Currently, Dr. Kloc is the Weill Cornell Professor of Cell and Molecular Biology at The Houston Methodist Hospital and the Adjunct Professor at Department of Genetics, University of Texas, M D AndersonCancer Center.

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