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Infectious Disease Modeling

A Hybrid System Approach

  • Imparts a quantitative understanding of the roles seasonality and population behavior play in the spread of a disease;
  • Illustrates formulation and theoretical analysis of mathematical disease models and control strategies;
  • Investigates how abrupt changes in the model parameters or function forms affect control schemes;
  • Explains techniques from switched and hybrid systems applicable to disease models as well as many other important applications in mathematics, engineering, and computer science;
  • Adopts a treatment accessible to individuals with a background in dynamic systems or with a background in epidemic modeling.

Part of the book series: Nonlinear Systems and Complexity (NSCH, volume 19)

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Table of contents (8 chapters)

  1. Front Matter

    Pages i-xvi
  2. Mathematical Background

    1. Front Matter

      Pages 1-1
    2. Basic Theory

      • Xinzhi Liu, Peter Stechlinski
      Pages 3-20
    3. Hybrid and Switched Systems

      • Xinzhi Liu, Peter Stechlinski
      Pages 21-39
  3. Hybrid Infectious Disease Models

    1. Front Matter

      Pages 41-41
    2. The Switched SIR Model

      • Xinzhi Liu, Peter Stechlinski
      Pages 43-82
    3. Epidemic Models with Switching

      • Xinzhi Liu, Peter Stechlinski
      Pages 83-132
  4. Control Strategies

    1. Front Matter

      Pages 133-133
    2. Switching Control Strategies

      • Xinzhi Liu, Peter Stechlinski
      Pages 135-178
    3. Pulse Control Strategies

      • Xinzhi Liu, Peter Stechlinski
      Pages 179-226
    4. A Case Study: Chikungunya Outbreak in Réunion

      • Xinzhi Liu, Peter Stechlinski
      Pages 227-257
  5. Conclusions and Future Work

    1. Front Matter

      Pages 259-259
    2. Conclusions and Future Directions

      • Xinzhi Liu, Peter Stechlinski
      Pages 261-263
  6. Back Matter

    Pages 265-271

About this book

This volume presents infectious diseases modeled mathematically, taking seasonality and changes in population behavior into account, using a switched and hybrid systems framework. The scope of coverage includes background on mathematical epidemiology, including classical formulations and results; a motivation for seasonal effects and changes in population behavior, an investigation into term-time forced epidemic models with switching parameters, and a detailed account of several different control strategies. The main goal is to study these models theoretically and to establish conditions under which eradication or persistence of the disease is guaranteed. In doing so, the long-term behavior of the models is determined through mathematical techniques from switched systems theory. Numerical simulations are also given to augment and illustrate the theoretical results and to help study the efficacy of the control schemes.


Reviews

“If you have a serious interest in the epidemiology of infectious diseases and are eager to roll up your sleeves, please consult this book … .” (Odo Diekmann, SIAM Review, Vol. 61 (1), March, 2019)

“This book focuses on infectious disease mathematical models, taking seasonality and changes in population behavior into account, using a switched and hybrid systems framework. … This book is strongly recommended to graduate level students with a background in dynamic system or epidemic modeling and an interest in mathematical biology, epidemic models, and physical problems exhibiting a mixture of continuous and discrete dynamics.” (Hemang B. Panchal, Doody’s Book Reviews, April, 2017)


“This book presents a new type of switched model for the spread of infectious diseases. … This book should be useful and attractive for students and researchers seeking updated progresses in the fieldof epidemic modeling … .” (Yilun Shang, zbMATH 1362.92002, 2017)

Authors and Affiliations

  • Department of Applied Mathematics, University of Waterloo, Waterloo, Canada

    Xinzhi Liu, Peter Stechlinski

About the authors

Xinzhi Liu is a Professor of Mathematics at the University of Waterloo. Peter Stechlinski is a Postdoctoral Fellow in the Process Systems Engineering Laboratory at the Massachusetts Institute of Technology

Bibliographic Information

Buy it now

Buying options

eBook USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 129.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access