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Neuropharmacology of New Psychoactive Substances (NPS)

The Science Behind the Headlines

  • Book
  • © 2017

Overview

Editors:
  1. Michael H. Baumann

    1. Designer Drug Research Unit (DDRU), National Institute on Drug Abuse, Baltimore, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Richard A. Glennon

    1. Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Jenny L. Wiley

    1. RTI International, Research Triangle Park, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Leading experts summarize the latest studies regarding the molecular mechanisms of action, behavioral effects, and adverse consequences of popular NPS
  • Specific chapters clarify the differences between various types of NPS, namely: stimulants, cannabinoids and hallucinogens
  • This volume broadens our understanding of NPS and provides insight into the rapidly evolving “new drug” phenomenon

Part of the book series: Current Topics in Behavioral Neurosciences (CTBN, volume 32)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-viii
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  2. The Growing Problem of New Psychoactive Substances (NPS)

    • Bertha K. Madras
    Pages 1-18

  3. Structure-Activity Relationships of Synthetic Cathinones

    • Richard A. Glennon, Małgorzata Dukat
    Pages 19-47

  4. Interactions of Cathinone NPS with Human Transporters and Receptors in Transfected Cells

    • Linda D. Simmler, Matthias E. Liechti
    Pages 49-72

  5. Electrophysiological Actions of Synthetic Cathinones on Monoamine Transporters

    • Ernesto Solis Jr.
    Pages 73-92

  6. Neuropharmacology of 3,4-Methylenedioxypyrovalerone (MDPV), Its Metabolites, and Related Analogs

    • Michael H. Baumann, Mohammad O. Bukhari, Kurt R. Lehner, Sebastien Anizan, Kenner C. Rice, Marta Concheiro et al.
    Pages 93-117

  7. Decoding the Structure of Abuse Potential for New Psychoactive Substances: Structure–Activity Relationships for Abuse-Related Effects of 4-Substituted Methcathinone Analogs

    • S. Stevens Negus, Matthew L. Banks
    Pages 119-131

  8. Reinforcing Effects of Cathinone NPS in the Intravenous Drug Self-Administration Paradigm

    • Lucas R. Watterson, M. Foster Olive
    Pages 133-143

  9. Predicting the Abuse Liability of Entactogen-Class, New and Emerging Psychoactive Substances via Preclinical Models of Drug Self-administration

    • Shawn M. Aarde, Michael A. Taffe
    Pages 145-164

  10. The Affective Properties of Synthetic Cathinones: Role of Reward and Aversion in Their Abuse

    • Heather E. King, Anthony L. Riley
    Pages 165-181

  11. MDMA, Methylone, and MDPV: Drug-Induced Brain Hyperthermia and Its Modulation by Activity State and Environment

    • Eugene A. Kiyatkin, Suelynn E. Ren
    Pages 183-207

  12. Neurotoxicology of Synthetic Cathinone Analogs

    • Mariana Angoa-Pérez, John H. Anneken, Donald M. Kuhn
    Pages 209-230

  13. Combination Chemistry: Structure–Activity Relationships of Novel Psychoactive Cannabinoids

    • Jenny L. Wiley, Julie A. Marusich, Brian F. Thomas
    Pages 231-248

  14. Pharmacological and Toxicological Effects of Synthetic Cannabinoids and Their Metabolites

    • Sherrica Tai, William E. Fantegrossi
    Pages 249-262

  15. Tripping with Synthetic Cannabinoids (“Spice”): Anecdotal and Experimental Observations in Animals and Man

    • Torbjörn U. C. Järbe, Jimit Girish Raghav
    Pages 263-281

  16. Pharmacology and Toxicology of N-Benzylphenethylamine (“NBOMe”) Hallucinogens

    • Adam L. Halberstadt
    Pages 283-311

  17. Clinical Pharmacology of the Synthetic Cathinone Mephedrone

    • Esther Papaseit, José Moltó, Robert Muga, Marta Torrens, Rafael de la Torre, Magí Farré
    Pages 313-331

  18. Application of a Combined Approach to Identify New Psychoactive Street Drugs and Decipher Their Mechanisms at Monoamine Transporters

    • Felix P. Mayer, Anton Luf, Constanze Nagy, Marion Holy, Rainer Schmid, Michael Freissmuth et al.
    Pages 333-350

  19. NPS: Medical Consequences Associated with Their Intake

    • Fabrizio Schifano, Laura Orsolini, Duccio Papanti, John Corkery
    Pages 351-380
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Keywords

About this book

Designer drugs, or new psychoactive substances (NPS), are synthetic chemicals that mimic the effects of classic drugs of abuse. There has been an alarming worldwide increase in the abuse of NPS in recent years. NPS are cheap, easy to obtain, and often legally available. In this volume, leading experts summarize the latest studies regarding the molecular mechanisms of action, behavioral effects, and adverse consequences of popular NPS. Specific chapters clarify the differences between various types of NPS, namely: stimulants, cannabinoids and hallucinogens. Thus, this volume broadens our understanding of NPS and provides insight into the rapidly evolving “new drug” phenomenon. 

  

Reviews

 “This book brings together an international panel of leading experts to summarize the latest studies regarding the mechanisms of actions, behavioral effects, and adverse consequences of popular ‘designer drugs.’ … The book is intended to provide useful information to scientists, clinicians, law enforcement agencies, and policymakers who are engaged in the responding to the growing phenomenon of the use of these drugs.” (Michael Easton, Doody's Book Reviews, August, 2017)

 

Editors and Affiliations

  • Designer Drug Research Unit (DDRU), National Institute on Drug Abuse, Baltimore, USA

    Michael H. Baumann

  • Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, USA

    Richard A. Glennon

  • RTI International, Research Triangle Park, USA

    Jenny L. Wiley

About the editors

 

Bibliographic Information

  • Book Title: Neuropharmacology of New Psychoactive Substances (NPS)

  • Book Subtitle: The Science Behind the Headlines

  • Editors: Michael H. Baumann, Richard A. Glennon, Jenny L. Wiley

  • Series Title: Current Topics in Behavioral Neurosciences

  • DOI: https://doi.org/10.1007/978-3-319-52444-3

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG (outside the USA) 2017

  • Hardcover ISBN: 978-3-319-52442-9Published: 25 April 2017

  • Softcover ISBN: 978-3-319-84906-5Published: 18 July 2018

  • eBook ISBN: 978-3-319-52444-3Published: 13 April 2017

  • Series ISSN: 1866-3370

  • Series E-ISSN: 1866-3389

  • Edition Number: 1

  • Number of Pages: VIII, 380

  • Number of Illustrations: 68 b/w illustrations, 13 illustrations in colour

  • Topics: Neurosciences, Psychopharmacology, Pharmacology/Toxicology, Public Health

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