Inflammation-Associated Depression: Evidence, Mechanisms and Implications

1. Front Matter

   Pages i-x

   PDF

2. Evidence for Inflammation-Associated Depression

   • Celina S. Liu, Alexander Adibfar, Nathan Herrmann, Damien Gallagher, Krista L. Lanctôt

   Pages 3-30

3. Role of Inflammation in the Development of Neuropsychiatric Symptom Domains: Evidence and Mechanisms

   • Lucile Capuron, Nathalie Castanon

   Pages 31-44

4. Inflammation-Associated Co-morbidity Between Depression and Cardiovascular Disease

   • Angelos Halaris

   Pages 45-70

5. Immune-to-Brain Communication Pathways in Inflammation-Associated Sickness and Depression

   • Charlotte D’Mello, Mark G. Swain

   Pages 73-94

6. Mechanisms of Inflammation-Associated Depression: Immune Influences on Tryptophan and Phenylalanine Metabolisms

   • Barbara Strasser, Barbara Sperner-Unterweger, Dietmar Fuchs, Johanna M. Gostner

   Pages 95-115

7. Role of the Kynurenine Metabolism Pathway in Inflammation-Induced Depression: Preclinical Approaches

   • Robert Dantzer

   Pages 117-138

8. Depression in Autoimmune Diseases

   • Christopher R. Pryce, Adriano Fontana

   Pages 139-154

9. Stress-Induced Microglia Activation and Monocyte Trafficking to the Brain Underlie the Development of Anxiety and Depression

   • Karol Ramirez, Jaime Fornaguera-Trías, John F. Sheridan

   Pages 155-172

10. Inflammation Effects on Brain Glutamate in Depression: Mechanistic Considerations and Treatment Implications

    • Ebrahim Haroon, Andrew H. Miller

    Pages 173-198

11. The Role of Dopamine in Inflammation-Associated Depression: Mechanisms and Therapeutic Implications

    • Jennifer C. Felger

    Pages 199-219

12. Brain Structures Implicated in Inflammation-Associated Depression

    • Neil A. Harrison

    Pages 221-248

13. Role of Kynurenine Metabolism Pathway Activation in Major Depressive Disorders

    • Jonathan Savitz

    Pages 249-267

14. Suicidality and Activation of the Kynurenine Pathway of Tryptophan Metabolism

    • Elena Y. Bryleva, Lena Brundin

    Pages 269-284

15. The Promise and Limitations of Anti-Inflammatory Agents for the Treatment of Major Depressive Disorder

    • Charles L. Raison

    Pages 287-302

16. Are Non-steroidal Anti-Inflammatory Drugs Clinically Suitable for the Treatment of Symptoms in Depression-Associated Inflammation?

    • Bernhard T. Baune

    Pages 303-319

17. Does Diet Matter? The Use of Polyunsaturated Fatty Acids (PUFAs) and Other Dietary Supplements in Inflammation-Associated Depression

    • Caitlín N. M. Hastings, Hannah Sheridan, Carmine M. Pariante, Valeria Mondelli

    Pages 321-338

18. Role of Neuro-Immunological Factors in the Pathophysiology of Mood Disorders: Implications for Novel Therapeutics for Treatment Resistant Depression

    • Anindya Bhattacharya, Wayne C. Drevets

    Pages 339-356

Inflammation has invaded the field of psychiatry. The finding that cytokines are elevated in various affective and psychotic disorders brings to the forefront the necessity of identifying the precise research domain criteria (RDoCs) that inflammation is responsible for. This task is certainly the most advanced in major depressive disorders. The reason is that a dearth of clinical and preclinical studies has demonstrated that inflammation can cause symptoms of depression and conversely, cytokine antagonists can attenuate symptoms of depression in medical and psychiatric patients with chronic low grade inflammation. Important knowledge has been gained on the symptom dimensions that inflammation is driving and the mechanisms of action of cytokines in the brain, providing new targets for drug research and development. The aim of the book “Inflammation-Associated Depression” is to present this field of research and its implications in a didactic and comprehensive manner to basic and clinical scientists, psychiatrists, physicians, and students at the graduate level.

• Biological Psychiatry
• Depression
• Inflammation
• Cytokine
• Indoleamine 2,3 dioxygenase
• Kynurenine
• Phenylalanine
• Tetrahydrobiopterin
• Obesity
• Cardiovascular disorders
• psychopharmacology

“This book covers important and growing field of knowledge associated with the role of inflammation in depression. … The book is well written and presented with many diagrams and illustrations. It covers the gap in this area of psychiatry research and potential for clinical practice and will be of interest for clinicians and researchers worldwide.” (Branka Aukst Margetic, Alcoholism and Psychiatry Research, Vol. 54 (01), June, 2018)



“The authors describe the current research data surrounding the role of inflammation and its impact on depression. … Each chapter begins with an abstract, identified keywords, and an outline of the chapter. Most chapters contain helpful graphics and conclude withreferences. … To my knowledge, this is the first book focused solely on the role of inflammation in psychiatry, which was confirmed by a quick internet search.” (Aaron Plattner, Doody’s Book Reviews, April, 2017)

• Department of Symptom Research, The University of Texas MD Anderson Cancer Center, Houston, USA

  Robert Dantzer

• Nutrition and Integrative Neurobiology, INRA, University of Bordeaux, Bordeaux, France

  Lucile Capuron

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